The present disclosure relates to methods of treating diseases and disorders comprising applying a therapeutically effective dose of cold plasma. In particular examples, the diseases and disorders include, but are not limited to, diseases and disorders of the skin, musculoskeletal, and immune systems.

The present disclosure relates to methods of treating diseases and disorders comprising applying a therapeutically effective dose of cold plasma. In particular examples, the diseases and disorders include, but are not limited to, diseases and disorders of the skin, musculoskeletal, and immune systems.

An oral care device may include: a body including a head; a plurality of teeth cleaning elements extending from the head; a first sacrificial electrode on the head; a second sacrificial electrode on the head and spaced apart from the first sacrificial electrode; a power source; and a controller configured to alternate between an ON state and an OFF state, wherein: in the ON state the controller operably couples the power source to the first and second sacrificial electrodes to create an electric potential between the first sacrificial electrode and the second sacrificial electrode, the electric potential having one of a first polarity and a second polarity, and for each successive transition from the OFF state to the ON state, the controller is configured to alternate between the first polarity and the second polarity.

Devices, systems, and methods for resecting tissue are disclosed. In some embodiments, a tissue resecting device may comprise an elongated structure having a longitudinal axis, the elongated structure comprising an outer sleeve with a distal window configured to receive uterine polyp tissue and an inner sleeve configured to move between a proximal position and a distal position relative to the window. In some further embodiments, the device may also comprise an electrode element coupled to the inner sleeve. In some even further embodiments, the device may include an insulative layer covering at least a portion of the inner sleeve, wherein the tissue resecting device is configured to fail when used to resect tissue more fibrous than uterine polyp tissue.

The invention relates to a device for producing a cold atmospheric pressure plasma for the treatment of human and/or animal surfaces, comprising a flexible, planar multilayer system with a side facing the surface to be treated and a side facing away from the surface to be treated, wherein the multilayer system comprises the following layers, namely a first electrode layer on the facing away side of the multilayer system, second electrode layer on the facing side of the multilayer system, wherein the electrode layer has a plurality of recesses or is formed in a grid-like or meander-shaped fashion, a dielectric layer arranged between the first electrode layer and the second electrode layer, and a spacer layer arranged adjacent the second electrode layer on the facing side of the multilayer system. In addition, the invention relates to a cable, a generator unit for providing a high voltage, and a system.

The invention relates to a device for producing a cold atmospheric pressure plasma for the treatment of human and/or animal surfaces, comprising a flexible, planar multilayer system with a side facing the surface to be treated and a side facing away from the surface to be treated, wherein the multilayer system comprises the following layers, namely a first electrode layer on the facing away side of the multilayer system, second electrode layer on the facing side of the multilayer system, wherein the electrode layer has a plurality of recesses or is formed in a grid-like or meander-shaped fashion, a dielectric layer arranged between the first electrode layer and the second electrode layer, and a spacer layer arranged adjacent the second electrode layer on the facing side of the multilayer system. In addition, the invention relates to a cable, a generator unit for providing a high voltage, and a system.

A system includes a focus optic configured to converge an electromagnetic radiation (EMR) beam to a focal region located along an optical axis. The system also includes a detector configured to detect a signal radiation emanating from a predetermined location along the optical axis. The system additionally includes a controller configured to adjust a parameter of the EMR beam based in part on the signal radiation detected by the detector. The system also includes a window located a predetermined depth away from the focal region, between the focal region and the focus optic along the optical axis, wherein the window is configured to make contact with a surface of a tissue.

A system includes a focus optic configured to converge an electromagnetic radiation (EMR) beam to a focal region located along an optical axis. The system also includes a detector configured to detect a signal radiation emanating from a predetermined location along the optical axis. The system additionally includes a controller configured to adjust a parameter of the EMR beam based in part on the signal radiation detected by the detector. The system also includes a window located a predetermined depth away from the focal region, between the focal region and the focus optic along the optical axis, wherein the window is configured to make contact with a surface of a tissue.

A facial beautifying and care apparatus includes a beauty bar (1) having an air supply passage (A), a negative pressure connecting hole (132), a conductive suction nozzle (15) and a first connection port (134); an EMS generation module (20) inside the beauty bar (1) electrically connected to the first connection port (134); an external negative pressure unit (6) separated from the beauty bar (1) and having a negative pressure driving control module (62) and a second connection port (637); the negative pressure driving control module (62) having an air supply tube assembly (66) with a negative pressure communicating hole (661); a communicating tube (7) communicating with the negative pressure connecting hole (132) and the negative pressure communicating hole (661); a conductive wire (8) connected to the first connecting port (134) and the second connecting port (637). Accordingly, the effects of facial skin firming, cleaning, beautifying and caring are achieved.

A non-thermal plasma for use in the treatment of an infected nail or infected skin. The plasma is used in the method by (a) applying the plasma to the infected nail or skin; (b) rehydrating the infected nail or skin; (c) applying the plasma to the infected nail or skin; and (d) optionally rehydrating the infected nail or skin.

In each of steps (a) and (c) the plasma is applied to a portion of the nail or skin until a hydration level of the plasma-treated portion drops by at most 30 wt % based on the initial moisture content of the plasma-treated portion.