A method of treating cancer in a subject that includes administering in situ to the cancer a therapeutically effective amount of a plant virus or virus-like particle to the subject.

The present invention relates to treatment of a psychiatric condition, for example resistant depression (RD), bipolar disorder (either threshold or sub-threshold) and/or major depressive disorder via application of repetitive transcranial magnetic stimulation with a drug treatment, in particular application of repetitive transcranial magnetic stimulation with treatment to modulate the activity of the neurones and induce neuroplasticity and the use of Thyroid hormone treatment to increase quantity or activity of thyroid hormones, for example for treatment of thyroid dysfunction. Patients may be selected for treatment by testing for the presence of normal thyroid function.

A method of treatment includes using an electrical energizing source coupled to a current conducting coil to cause the current conducting coil to produce pulsed electromagnetic fields. A conducting membrane is placed adjacent the current conducting coil and an insulating coupling interface is placed adjacent the membrane, such that the membrane is between the current conducting coil and the insulating coupling interface. One portion of the pulsed electromagnetic fields is intercepted by the membrane so that the membrane oscillates to generate acoustic waves to tissue adjacent the insulating coupling interface and another portion of the pulsed electromagnetic fields propagates through the insulating coupling interface to the tissue.

Embodiments of the present disclosure include a system for applying therapeutic pressure to a skin surface including a tip arranged at a first end of a therapeutic wand. The system also includes a head arranged opposite the tip at a second end of the therapeutic wand. The system includes a body arranged between the tip and the head, the body housing a control system for controlling operation of the therapeutic wand. The control system includes a printed circuit board, a timer electrically connected to the printed circuit board, the timer being programmable to determine an elapsed time of use of the therapeutic wand, and an indicator. The system also includes a grip arranged between the body and the head, the grip having an outer surface that is softer than the body to provide an ergonomic and comfortable location to hold the therapeutic wand.

Systems and method for destroying or inhibiting cancer cells and other rapidly-dividing cells include applying AP magnetic fields having a defined frequency of 5 Hz-500 kHz and a field strength of 0.1-5000 μT to a target body area that includes the cancer or other rapidly-dividing cells, and modifying the cancer or tumor microenvironment to increase the presence of cancer-suppressive cells or decrease the presence of cancer-promoting cells. In various embodiments, the systems and methods may include adjusting the therapy based on the dosage of an immunotherapy drug administered to the patient before, during, or after the application of the AP magnetic fields.

A disposable housing including a single-use thermal exchange component can be configured to be mechanically, removably coupled to a receptacle on a cuff positionable around a joint to provide temperature-based therapy to the joint.

In one embodiment of the present invention, an implantable blood pump includes a housing defining a flow path, a rotor positioned within the flow path, and a motor including a stator, positioned outside of said housing, the stator including a length of silver wire, wherein the silver wire is not positioned within a hermetically sealed compartment once the blood pump is ready for implantation into a patient in need thereof. The present invention may also include a method of implanting the implantable blood pump including the step of implanting the blood pump within the patient and within or adjacent to the vasculature.

The present invention provides a device for rejuvenating a region of skin or mucosal tissue, comprising: a pulsed electromagnetic frequency generator; a plurality of electrodes in communication with the pulsed electromagnetic frequency generator and an RF tissue diathermy device. The electrodes apply the pulsed electromagnetic power and the RF tissue diathermy to the tissue, heating it such that one portion of the region of mucosal tissue is maintained at a predetermined temperature range T.sub.1 while another portion of the region of mucosal tissue is at least temporarily maintained at predetermined temperature range T.sub.2.

The present disclosure provides an equine therapy boot and methods of attaching the equine therapy boot to a lower extremity of a horse leg and hoof. The equine therapy boot includes an upper portion and a lower portion and an attachment means for securing the upper portion to the lower portion. The upper portion includes a fluid containment area for holding a thermal control fluid in proximity to a portion of the horse leg selected to receive treatment.

A training device for improving insomnia is provided, comprising a virtual reality unit and a control unit. The virtual reality unit comprises two earphones and an eye cover connected to the earphones. When the control unit executes the daytime relaxaion-assisted program, the control unit controls the earphones to play a daytime binaural beats with frequency following response. The daytime binaural beats with frequency following response have a first main carrier frequency tone and a first loading frequency tone differing from the first main carrier frequency tone by a first difference frequency rate. When the control unit executes the nighttime anti-insomnia-assisted program, the control unit controls the earphones to play the nighttime difference frequency tone. The nighttime difference frequency tone have a second main carrier frequency tone and a second loading frequency tone differing from the second main carrier frequency tone by a second difference frequency rate.