Systems and method for destroying or inhibiting cancer cells and other rapidly-dividing cells include applying AP magnetic fields having a defined frequency of 5 Hz-500 kHz and a field strength of 0.1-5000 μT to a target body area that includes the cancer or other rapidly-dividing cells, and modifying the cancer or tumor microenvironment to increase the presence of cancer-suppressive cells or decrease the presence of cancer-promoting cells. In various embodiments, the systems and methods may include adjusting the therapy based on the dosage of an immunotherapy drug administered to the patient before, during, or after the application of the AP magnetic fields.

A method of stimulation treatment for medical disorders using stimulation parameters that provide stimulation of a target site directly or create partial stimulation signals that combine into vector signals that stimulate a target site. Stimulation signals have characteristics such as frequency, timing, temporal content that is adjusted for the person being treated. Signals are designed with advantageous characteristics to influence target tissue in an intended manner and avoid producing unwanted side-effects. Stimulation signals are designed to match or avoid internal/endogenous activity (e.g., brain patterns and rhythms) of a patient. Methods for choosing, creating and partial signals are provided. Tissue modulation may be accomplished with electrical and/or magnetic stimulation, such as repetitive transcranial magnetic stimulation.

A magnetic stimulation system may include first and second subsystems. The first subsystem may include a first stimulator, a first coil, and a first processor configured to determine stimulation parameter data for a subject. The second subsystem may include a second stimulator, a headpiece including an identifier and a second coil mounted to a headpiece body at a fixed location, an image recording device, and a second processor configured to: receive first image data for one or more first images of the subject and headpiece; receive, from the image recording device, second image data for one or more second images of the subject and headpiece; determine, using the first and second image data, that the stimulation parameter data corresponds to the subject; determine, using the second image data, that the headpiece corresponds to the subject; and determine, using the second image data, that the headpiece is at a pre-determined position.

A magnetic stimulation system may include first and second subsystems. The first subsystem may include a first stimulator, a first coil, and a first processor configured to determine stimulation parameter data for a subject. The second subsystem may include a second stimulator, a headpiece including an identifier and a second coil mounted to a headpiece body at a fixed location, an image recording device, and a second processor configured to: receive first image data for one or more first images of the subject and headpiece; receive, from the image recording device, second image data for one or more second images of the subject and headpiece; determine, using the first and second image data, that the stimulation parameter data corresponds to the subject; determine, using the second image data, that the headpiece corresponds to the subject; and determine, using the second image data, that the headpiece is at a pre-determined position.

The present invention relates to a stimulation apparatus (10), comprising a magnetic stimulation unit (20), and a processing unit (30). The processing unit is configured to control the magnetic stimulation unit to provide intentional nerve and/or muscle stimuli to a peripheral body part of a patient.

Systems and methods for treatment of a mental disorder of a subject are disclosed. The methods include receiving a first set of electroencephalography (“EEG”) measurements that each correspond to brain activity at one or more of a plurality of zones of a brain of the subject. The methods further include determining a target frequency for the subject based on the first set of EEG measurement where, the target frequency being an EEG frequency where the brain of the subject operates optimally across a plurality of EEG channels in an alpha brainwave, and generating a treatment protocol for the subject based on the target frequency. The treatment protocol includes one or more individualized transcranial magnetic stimulation (TMS) treatments that each include application a plurality of magnetic stimulation pulses for a defined time period and at a frequency of about the target frequency.

A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a CD8 T-cell, a CD4 T-cell, a B-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.

A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a CD8 T-cell, a CD4 T-cell, a B-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.

A coil apparatus for use in a transcranial magnetic stimulation apparatus is provided to further increase an electric field intensity on a head surface. The coil apparatus includes a wound-wire coil disposed on or near a head surface so as to generate a current by an induced electric field through electromagnetic induction in a magnetic stimulation-target region of a brain for stimulating neurons. The wound-wire coil includes a near-head-surface conductive wire portion disposed on or near the head surface, and a far-head-surface conductive wire portion disposed farther from the head surface than the near-head-surface conductive wire portion. A distance between the near-head-surface conductive wire portion and the far-head-surface conductive wire portion is set to be changed so that an intensity of the induced electric field becomes larger than that of a surrounding region of the magnetic stimulation-target region.

A coil apparatus for use in a transcranial magnetic stimulation apparatus is provided to further increase an electric field intensity on a head surface. The coil apparatus includes a wound-wire coil disposed on or near a head surface so as to generate a current by an induced electric field through electromagnetic induction in a magnetic stimulation-target region of a brain for stimulating neurons. The wound-wire coil includes a near-head-surface conductive wire portion disposed on or near the head surface, and a far-head-surface conductive wire portion disposed farther from the head surface than the near-head-surface conductive wire portion. A distance between the near-head-surface conductive wire portion and the far-head-surface conductive wire portion is set to be changed so that an intensity of the induced electric field becomes larger than that of a surrounding region of the magnetic stimulation-target region.