Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.

Methods and apparatuses are provided for reducing sweat production via, for example, the removal, disablement, and incapacitation of sweat glands in the epidermis, dermis and subdermal tissue regions of a patient. In one embodiment, a method of treating a patient is provided which involves identifying a patient having a condition of excessive sweating, positioning an energy delivery device proximate to a skin tissue of the patient and delivering energy to sweat glands to halt secretion of sweat. The energy delivery device may include microwave delivery devices, RF delivery devices, and cryogenic therapy devices. Some embodiments may include using a cooling element for avoiding destruction of non-target tissue and/or a suction device to localize treatment at specific portions of the skin fold.

An apparatus used for increasing the level of CD4.sup.+T cells in a mammal. The mammal has a cancerous tissue. The apparatus comprises a cold treatment unit and a heat treatment unit. The cold treatment unit is used for cooling the cancerous tissue. The heat treatment unit is used for heating the cancerous tissue. A method for increasing the level of CD4.sup.+ T cells in the body of a cancer patient, comprising steps for cold treatment of the cancerous tissue and for heat treatment of the cancerous tissue.

A device for providing hyperthermia treatment includes an ultrasound energy generator configured to apply low intensity ultrasound to target tissue. The low intensity ultrasound energy induces therapeutic heating in the tissue at or below the surface of the skin. In order to control the temperature of the tissue during therapy, a microwave radiometer, such as a Dicke radiometer, can be used to measure the temperature of the tissue and feed back the temperature measurement to the ultrasound energy generator to control ultrasonic energy produced and control the temperature of the target tissue.

A device for providing hyperthermia treatment includes an ultrasound energy generator configured to apply low intensity ultrasound to target tissue. The low intensity ultrasound energy induces therapeutic heating in the tissue at or below the surface of the skin. In order to control the temperature of the tissue during therapy, a microwave radiometer, such as a Dicke radiometer, can be used to measure the temperature of the tissue and feed back the temperature measurement to the ultrasound energy generator to control ultrasonic energy produced and control the temperature of the target tissue.

To provide medical treatment equipment, a medical treatment system, a control method for the medical treatment equipment, and a non-transitory storage medium storing a control program for the medical treatment equipment that can perform an optimal treatment in accordance with a state of the affected area. Medical treatment equipment acquires measurement information from a bending sensor of a sensor unit attached to the knee region of a user, evaluates a movable range of the knee region based on the measurement information (step S2), and controls the output of each of a first electrode pad and a second electrode pad based on the evaluation result (step S3, step S4).

To provide medical treatment equipment, a medical treatment system, a control method for the medical treatment equipment, and a non-transitory storage medium storing a control program for the medical treatment equipment that can perform an optimal treatment in accordance with a state of the affected area. Medical treatment equipment acquires measurement information from a bending sensor of a sensor unit attached to the knee region of a user, evaluates a movable range of the knee region based on the measurement information (step S2), and controls the output of each of a first electrode pad and a second electrode pad based on the evaluation result (step S3, step S4).

The invention relates to medical therapy of detrimental lesions. A system treats with non-invasive arrays of non-ionizing energy-radiation sources. The external sources focus energy dose distribution to a selected volume in a body. Energy output is directed towards a pathologic location and quenched around other sites or healthy tissue. Beam aiming is done without source movement. Targeted, volumetrically discrete energy deposition can beneficially manipulate lesions within the body. The purpose of the focused and enhanced energy deposition is to repair or disable pathologic physiology or structures, nerve pathways, extracellular fluid, and misfolded proteins. Locally augmented energy is used to enhance immunity, release pharmaceutical compounds from energy-sensitive vesicles and reconfigure or eliminate misfolded proteins and their aggregates. Targeted tissue may have enhanced sensitivity to received energy via a non-ionizing-radiation, treatment-localizing agent. This system optimizes delivery of non-ionizing, non-ablating electromagnetic or mechanical energy, degrading or repairing an abnormality upon interaction with it.

There is disclosed a method of treating affected external or surface tissue comprising the steps of providing a source of affected external or surface tissue; generating a source of microwave energy; transmitting said microwave energy into said affected external or surface tissues; exposing said affected external and surface tissues to said microwave energy to raise the local temperature to thereby ablate, remove, coagulate or otherwise alter said affected external and surface tissues. There is also disclosed an apparatus for the treatment of affected external and surface tissues comprising a microwave energy source generator, a means to transmit said microwave energy into said affected external or surface tissues, a means to control the exposure of said affected external and surface tissues to said microwave energy to raise the local temperature to thereby ablate, remove, coagulate or otherwise alter said affected external and surface tissues; and optionally a means to control the repetition of steps a) to d) multiple times until the ablation, removal, coagulation or otherwise alteration is complete, the period between each sequence of steps a) to d) being optionally cooled, and the location of said concentrated electric field being varied.

These teachings include accessing energy dosing information along with at least one quality-of-care model that correlates at least one categorical energy-based treatment patient quality-of-care outcome with at least one resultant energy-based treatment description. The model can be created via probabilistic mapping that maps patient impact information to dose impartation information to infer non-biological impact to a patient. A patient treatment plan can be optimized for a particular patient as a function of the foregoing information to provide corresponding resultant benefit trade-of evaluation information. This benefit trade-off evaluation information can be displayed to a user to permit the user to explore the benefit trade-off evaluation information to thereby identify a resultant energy-based treatment plan having a selected balance between dosing a treatment target with energy and a quality-of-care impact on the particular patient.