A method may include obtaining first image data relating to a region of interest (ROI) of a first subject. The first image data corresponding to a first equivalent dose level may be acquired by a first device. The method may also include obtaining a model for denoising relating to the first image data and determining second image data corresponding to an equivalent dose level higher than the first equivalent dose level based on the first image data and the model for denoising. In some embodiments, the method may further include determining information relating to the ROI of the first subject based on the second image data and recording the information relating to the ROI of the first subject.

Techniques for closed-loop feedback beam control in particle therapy delivery system can include receiving treatment plan beam parameters, receiving a determined output beam current of a present spot, generating an adjusted source beam current set point based on the treatment plan beam parameters and the determined output beam current of the present spot, and adjusting an output beam current of the present spot based on the adjusted source beam current.

The system comprises an input device for collecting a comprehensive pathological database obtained from two types of patients selected from cancer patients of each cancer stage, which exhibit uncontrolled growth of cells, localized to a tissue mass, spreaded in an organ or throughout the body through blood and immunologically compromised patients, having hypo immune tendency or hyper immunological conditions; a pre-processor for removing noise from collected comprehensive pathological database; a training processor configured with a deep learning technique for training back propagation network (BPN) using pathological tests of cancer patients and immunologically abnormal patients; a classification processor for categorizing patients based on extent of diseases using back propagation network (BPN); and a central processor equipped with a radiotherapy device for using the autoimmunity of the patients upon triggering the autoimmunity of the patients in the concerned tissue, organ or the blood for killing the cancer cells to control the infection.

The system comprises an input device for collecting a comprehensive pathological database obtained from two types of patients selected from cancer patients of each cancer stage, which exhibit uncontrolled growth of cells, localized to a tissue mass, spreaded in an organ or throughout the body through blood and immunologically compromised patients, having hypo immune tendency or hyper immunological conditions; a pre-processor for removing noise from collected comprehensive pathological database; a training processor configured with a deep learning technique for training back propagation network (BPN) using pathological tests of cancer patients and immunologically abnormal patients; a classification processor for categorizing patients based on extent of diseases using back propagation network (BPN); and a central processor equipped with a radiotherapy device for using the autoimmunity of the patients upon triggering the autoimmunity of the patients in the concerned tissue, organ or the blood for killing the cancer cells to control the infection.

Systems and methods are disclosed for performing operations comprising: receiving dose information representing dose delivered during a first radiotherapy treatment fraction; accessing one or more previous dose information representing dose delivered during one or more previous radiotherapy treatment fractions; computing a measure of biologically effective dose (BED) based on a combination of the dose information delivered during a first radiotherapy treatment fraction and the dose delivered during the one or more previous radiotherapy treatment fractions; and performing an isotoxic planning process for delivering a second radiotherapy treatment fraction following the first radiotherapy treatment fraction based on the computed measure of BED.

The present invention provides a radiotherapeutical or radiosurgical system comprising at least two high-intensity radiation sources configured to rotate around a common rotation axis and a ring-shaped imaging device. A three-source configuration is considered as the most cost-effective and will be used as an example for illustration. The three radiation sources are specially configured with each radiation source emits a radiation beam having an angle (α1, α2 or α3 respectively) relative to the common rotation axis and targets at a common isocenter. During a radiation treatment, the angles α1, α2 and α3 are independently of each other constant or variable with a magnitude of less than ±15°, and it always remains that α1≠α2, α1≠α3, and α2≠α3. The special configuration of these high-intensity radiation sources and use of a unique compact MLC for each of the radiation sources make it possible for the system to rapidly deliver high-conformal non-coplanar stereotactic radiation treatment in one gantry rotation without any couch rotation. Consequently, a ring-shaped imaging device, which does not allow couch rotation, can be integrated into the system to provide high-precision image guidance. Therefore, the present invention can deliver high precision and high-conformal non-coplanar stereotactic radiation treatment to any part of the body in an extremely short time (0.1-20 seconds), which may exhibit numerous advantages over the prior art, such as reduction of radiation damage to the circulating immune cells in blood and mitigation of patient motion-induced problems, among others.

The present disclosure may provide a radiation system including a first rotation portion, a second rotation portion, a treatment head, one or more imaging sources, and at least one detector. At least a portion of the treatment head may be disposed in the first rotation portion. At least one of the one or more imaging sources may be disposed in the second rotation portion. The second rotation portion may be able to rotate independently from the first rotation portion.

A radiation delivery system and method of operation are described. The method includes modulating a sub-beam intensity of a radiation beam generated by a radiation source across a plurality of sub-beams that subdivide a fluence field into a two-dimensional (2D) grid, and delivering a plurality of independent two-dimensional (2D) sub-beam intensity patterns from a plurality of angles while the radiation source is moved continuously.

A method may include obtaining a first image related to one or more target objects generated by a first scan. The method may also include obtaining a first radiation therapy plan for treating the one or more target objects. The method may also include obtaining a second image related to the one or more target objects generated by a second scan. The second scan may be performed later than the first scan. The method may also include determining, based on the first radiation therapy plan, the first image, and the second image, a target radiation therapy plan to treat the one or more target objects. The target radiation therapy plan may be the first radiation therapy plan or a second radiation therapy plan associated with the second image, wherein at least a portion of the determining the target radiation therapy plan may be performed in parallel.

A radiation therapy system is capable of widening a radiation irradiation range to a patient and includes: a radiation source; a rotation mechanism that supports the radiation source in rotation around an isocenter; a couch that places a therapy target site of a patient at the isocenter; a head swing mechanism that is disposed between the radiation source and the rotation mechanism and that swings an irradiation axis of a radiation emitted from the radiation source by swinging the radiation source; and a controller. The controller holds the head swing mechanism in a state where the irradiation axis of the radiation of the radiation source is shifted from the isocenter in a predetermined direction by a predetermined amount, and rotates the radiation source by the rotation mechanism while emitting the radiation from the radiation source while maintaining the state of the head swing mechanism.