A radiotherapy device control apparatus instructs a radiotherapy device to execute instruction information based on a treatment regimen determined in advance, controls the operations of an irradiation-related instrument provided in the radiotherapy device on the basis of irradiation conditions included in the instruction information, determines whether irradiation is permitted on the basis of results detected by an irradiation target detection unit that detects movement of a target to be irradiated, controls execution and interruption of therapeutic irradiation on the basis of the determined result, stores the history of interruption of irradiation according to the determination by the irradiation permission determination unit, and causes the instrument to run the operations based on the instruction information to completion, regardless of whether irradiation has been interrupted during execution of the instruction information.

A radiotherapy device control apparatus instructs a radiotherapy device to execute instruction information based on a treatment regimen determined in advance, controls the operations of an irradiation-related instrument provided in the radiotherapy device on the basis of irradiation conditions included in the instruction information, determines whether irradiation is permitted on the basis of results detected by an irradiation target detection unit that detects movement of a target to be irradiated, controls execution and interruption of therapeutic irradiation on the basis of the determined result, stores the history of interruption of irradiation according to the determination by the irradiation permission determination unit, and causes the instrument to run the operations based on the instruction information to completion, regardless of whether irradiation has been interrupted during execution of the instruction information.

Disclosed is a method for increasing susceptibility of cancer cells to ionizing radiation by delivering to the cells a radiosensitizing agent that has one of the following properties: (a) it perturbs the process of chromosome segregation thereby increasing chromosome missegregation; or (b) it is an inhibitor of an agent that promotes faithful chromosome segregation induces numeric chromosome instability in said cells and this instability is induced substantially simultaneously with or closely prior to or closely after irradiating the cells. Examples of such radiosensitizing agent include inhibitors of one or more of the following: Kif2b, MCAK, MPS1, Eg5/Kinesin-5 5, Polo-like kinase 4, MCAK, Bub1 and Hec1. Such agents specifically target proteins involved in maintaining or promoting faithful chromosome segregation.

Disclosed is a method for increasing susceptibility of cancer cells to ionizing radiation by delivering to the cells a radiosensitizing agent that has one of the following properties: (a) it perturbs the process of chromosome segregation thereby increasing chromosome missegregation; or (b) it is an inhibitor of an agent that promotes faithful chromosome segregation induces numeric chromosome instability in said cells and this instability is induced substantially simultaneously with or closely prior to or closely after irradiating the cells. Examples of such radiosensitizing agent include inhibitors of one or more of the following: Kif2b, MCAK, MPS1, Eg5/Kinesin-5 5, Polo-like kinase 4, MCAK, Bub1 and Hec1. Such agents specifically target proteins involved in maintaining or promoting faithful chromosome segregation.

A treatment planning apparatus includes an overall data management unit for storing a target irradiation dose distribution to be formed in an irradiation object, a broad irradiation parameter calculation unit and a scanning irradiation parameter calculation unit for cooperatively calculating and determining operational parameters for devices, such as an accelerator and an irradiation nozzle, to operate during a broad irradiation and an scanning irradiation, respectively, so that the sum of irradiation doses imparted by both broad irradiation and scanning irradiation forms the target irradiation dose distribution.

A treatment planning apparatus includes an overall data management unit for storing a target irradiation dose distribution to be formed in an irradiation object, a broad irradiation parameter calculation unit and a scanning irradiation parameter calculation unit for cooperatively calculating and determining operational parameters for devices, such as an accelerator and an irradiation nozzle, to operate during a broad irradiation and an scanning irradiation, respectively, so that the sum of irradiation doses imparted by both broad irradiation and scanning irradiation forms the target irradiation dose distribution.

A restraint system for a patient to be exposed to a radiation beam is disclosed. The system includes a patient support panel and a head restraint assembly in the form of a face mask to which plural clips are secured. The patient support panel includes plural connectors, which may include fixed or adjustable connectors. The clips include are configured to engage the plural connectors in a snap-on manner, without the need for tools or separate fastening devices.

A restraint system for a patient to be exposed to a radiation beam is disclosed. The system includes a patient support panel and a head restraint assembly in the form of a face mask to which plural clips are secured. The patient support panel includes plural connectors, which may include fixed or adjustable connectors. The clips include are configured to engage the plural connectors in a snap-on manner, without the need for tools or separate fastening devices.

Embodiments now disclosed herein provide an apparatus and method in which free radicals can be detected in a substance by MRI without changing the MRI static field.

The present invention relates to methods of treating hematologic cancers using a combination of inhibitors of PD-1 or PD-L1 and TIM-3, LAG-3 or CTLA4.