The present invention relates to methods of treating hematologic cancers using a combination of inhibitors of PD-1 or PD-L1 and TIM-3, LAG-3 or CTLA4.

Cancer cells can be synchronized to the G2/M phase by delivering an anti-microtubule agent (e.g., paclitaxel or another taxane) to the cancer cells, and applying an alternating electric field with a frequency between 100 and 500 kHz to the cancer cells, wherein at least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. This synchronization can be taken advantage of by treating the cancer cells with radiation therapy after the combined action of the delivering step and the applying step has increased a proportion of cancer cells that are in the G2/M phase. The optimal frequency and field strength will depend on the particular type of cancer cell being treated. For certain cancers, this frequency will be between 125 and 250 kHz (e.g., 200 kHz) and the field strength will be at least 1 V/cm.

Cancer cells can be synchronized to the G2/M phase by delivering an anti-microtubule agent (e.g., paclitaxel or another taxane) to the cancer cells, and applying an alternating electric field with a frequency between 100 and 500 kHz to the cancer cells, wherein at least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. This synchronization can be taken advantage of by treating the cancer cells with radiation therapy after the combined action of the delivering step and the applying step has increased a proportion of cancer cells that are in the G2/M phase. The optimal frequency and field strength will depend on the particular type of cancer cell being treated. For certain cancers, this frequency will be between 125 and 250 kHz (e.g., 200 kHz) and the field strength will be at least 1 V/cm.

Provided herein are devices and methods generating a panoramic rendering of a subject's teeth. Methods and processes are provided to image the subject's teeth with a dental scan. Methods and processes are also provided to automatically 3D render the subject's teeth with the scan images. Methods and apparatuses are also provided to generate simulated panoramic views of the subject's dentition from various perspectives.

Disclosed herein are systems and methods for identifying radiation therapy treatment data for different patients, such as field geometry. A central server collects patient data, radiation therapy treatment planning data, clinic-specific rules, and other pertinent treatment/medical data associated with a patient. The server then executes one or more machine-learning computer models to predict field geometry variables and weights associated with the patient's treatments. Using the predicted variables and weights, the server execute a clinic-specific set of logic to identify suggested field geometry, such as couch/gantry angles and/or arc attributes. The server then monitors whether end users (e.g., medical professionals) revise the suggested field geometry and trains the model accordingly.

Methods, systems, and compositions for maintaining functioning drainage blebs to reduce intraocular pressure (IOP) of an eye being treated for glaucoma. The methods, systems, and compositions feature the combination of a minimally invasive glaucoma surgery (MIGS) implant or procedure and the application of beta radiation to the bleb. The beta radiation can function to inhibit or reduce the inflammation and/or fibrogenesis that typically occurs after insertion of a MIGS implant and leads to bleb failure. By reducing inflammation and/or fibrogenesis, the MIGS implant and the blebs can remain functioning appropriately.

The present invention provides clinical evidence for a method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring myeloablative conditioning.

A method for dynamically estimating a biological effect of a variable combination of non-photon radiation in accordance with a relative biological effectiveness, RBE, model including at least one biological effect multiplier δ(T, E) which depends on particle type T and/or particle energy E, the method comprising: obtaining one or more non-photon radiation contributions D.sup.(i)(T, E), 1 ≤ i ≤ N, at least one of said contributions including multiple particle types and/or multiple particle energies; storing per-contribution dose-weighted averages δ̅.sup.(i), 1 ≤ i ≤ N, of said at least one biological effect multiplier with respect to each of the one or more contributions; and in response to obtaining an assignment Π of the combination, the assignment being in terms of non-negative coefficients k.sub.1, k.sub.2, ..., k.sub.N ≥ 0 to be applied to the one or more contributions, determining a biological effect of the combination, including computing a combined dose-weighted average δ̅.sup.Π of said at least one biological effect multiplier on the basis of the stored per-contribution dose-weighted averages.

A reusable joint for a medical linac, a reusable CF choke flange for a medical linac, a linac and a method for forming a reusable joint for a medical linac are disclosed. The reusable joint comprises a CF choke flange, a CF cover flange and a gasket. The CF choke flange comprises a first waveguide aperture, a choke groove and a first CF groove comprising a first knife-edge, wherein the choke groove is disposed radially inwards from the first CF groove on the CF choke flange. The CF cover flange comprises a second waveguide aperture aligned with the first waveguide aperture and a second CF groove comprising a second knife-edge and aligned with the first CF groove. The gasket is disposed between and in contact with the first CF groove and the second CF groove.

The invention relates to a system for determining a radiation therapy plan for a radiation therapy system (100), comprising a multi-leaf collimator. The radiation therapy plan determination system (110) comprises a therapy system characteristics providing unit (111), wherein the characteristics comprise possible leaf positions and possible radiation fluence values, a planning objectives providing unit (112), wherein the planning objectives are indicative of a desired therapeutic radiation dose distribution, an optimization function providing unit (113), wherein the optimization function is indicative of a deviation of a radiation dose distribution from the planning objectives and of an uncertainty of the radiation dose distribution at edges of the possible apertures, and a therapy plan optimization unit (114) adapted to determine a sequence of possible apertures and possible radiation fluence values for which the optimization function is optimized. Thus, an optimal therapy plan can be provided for each individual patient.