Embodiments of the invention are directed to the treatment of subjects with prostate cancer, in particular those with castration resistant prostate cancer, with glucocorticoid receptor antagonists. The prostate cancer may be one that has become resistant to androgen deprivation therapy, for example, by increase in glucocorticoid receptor expression and/or activity.

Embodiments of the invention are directed to the treatment of subjects with prostate cancer, in particular those with castration resistant prostate cancer, with glucocorticoid receptor antagonists. The prostate cancer may be one that has become resistant to androgen deprivation therapy, for example, by increase in glucocorticoid receptor expression and/or activity.

A method of generating a treatment plan for treating a patient with radiotherapy, the method includes obtaining a plurality of sample plans, which are generated by use of a knowledge base comprising historical treatment plans and patient data. The method also includes performing a multi-criteria optimization based on the plurality of sample plans to construct a Pareto frontier, where the plurality of sample plans are evaluated with at least two objectives measuring qualities of the plurality of sample plans such that treatment plans on the constructed Pareto frontier are Pareto optimal with respect to the objectives. The method further includes identifying a treatment plan by use of the constructed Pareto frontier.

A system for determining a treatment plan in active ion beam treatment, to minimize unwanted dose, while maintaining or improving target dose coverage, whereby a beam is split into at least two sub-beams and where each sub-beam has a range shifter of different settings.

Disclosed is a computer-implemented method for determining a position of an anatomical tracking structure in a tracking image usable for controlling a radiation treatment such as at least one of radiotherapy or radio surgery of a patient, a corresponding computer program, a non-transitory program storage medium storing such a program and a computer for executing the program, as well as a system for the position of an anatomical tracking structure in a tracking image usable for controlling a radiation treatment such as at least one of radiotherapy or radio surgery of a patient, a system comprising an electronic data storage device and the aforementioned computer.

Disclosed is a computer-implemented method for determining a position of an anatomical tracking structure in a tracking image usable for controlling a radiation treatment such as at least one of radiotherapy or radio surgery of a patient, a corresponding computer program, a non-transitory program storage medium storing such a program and a computer for executing the program, as well as a system for the position of an anatomical tracking structure in a tracking image usable for controlling a radiation treatment such as at least one of radiotherapy or radio surgery of a patient, a system comprising an electronic data storage device and the aforementioned computer.

Disclosed herein is a method of determining the nature of a fault in a radiotherapy device comprising a linear accelerator. The radiotherapy device is configured to provide therapeutic radiation to a patient. The radiotherapy device comprises a vacuum tube comprising an electron gun, a waveguide configured to accelerate electrons emitted by the electron gun toward a target to produce said radiation, and a flight tube. The electron gun is located at a first end of the vacuum tube and the flight tube is located at a second end of the vacuum tube. The radiotherapy device further comprises a first and a second sensor. The first sensor is configured to provide signals indicative of pressure at a first region inside the vacuum tube and the second sensor is configured to provide signals indicative of pressure at a second region inside the vacuum tube. The first region is closer to the first end of the vacuum tube than the second region is. The method comprises processing a first value derived from signals from the first sensor and a second value derived from signals from the second sensor. The first value is indicative of pressure at the first region inside the vacuum tube, and the second value is indicative of pressure at the second region inside the vacuum tube. Processing the first and second value comprises comparing the first value with a first threshold and comparing the second value with a second threshold; and, based on the processing of the signals, determining that the nature of the fault is associated with the flight tube.

Described herein are systems and methods of processing immobilization molds for application of treatment, A computing system may generate a three-dimensional mold model of immobilization mold within with a subject is to be positioned for application of a treatment. The computing system may subtract a three-dimensional scan of at least a portion of the subject from the three-dimensional mold model to define an opening therein. The computing system may remove, from the three-dimensional mold model, a first portion to define an imprint in the opening from a first axis along which the subject is to enter. The computing system may remove, from a second portion of the three-dimensional mold model remaining with the removal of the first portion, inward protrusions into the imprint of relative to the second axis intersecting the first axis.

Described herein are systems and methods of processing immobilization molds for application of treatment, A computing system may generate a three-dimensional mold model of immobilization mold within with a subject is to be positioned for application of a treatment. The computing system may subtract a three-dimensional scan of at least a portion of the subject from the three-dimensional mold model to define an opening therein. The computing system may remove, from the three-dimensional mold model, a first portion to define an imprint in the opening from a first axis along which the subject is to enter. The computing system may remove, from a second portion of the three-dimensional mold model remaining with the removal of the first portion, inward protrusions into the imprint of relative to the second axis intersecting the first axis.

An optical stimulation system includes a light source; an optical lead coupled, or coupleable, to the light source; at least one of a calibration table or a calibration formula, generated by a calibration procedure specifically using the light source and the optical lead of the optical stimulation system; and a control unit coupled, or coupleable, to the light source. The control module includes a memory to store the at least one of the calibration table or the calibration formula, and a processor coupled to the memory and configured for receiving a target light output level, using the at least one of the calibration table or the calibration formula to determine at least one operational parameter for generating the target light output level, and directing the light source, using the at least one operational parameter, to generate light at the target light output level.