In a circular accelerator that applies a radiofrequency wave in a main magnetic field to accelerate charged particle beam while increasing an orbit radius, another radiofrequency wave with a frequency different from the radiofrequency wave used for acceleration is applied to the charged particle beam in order to extract the charged particle beam. Thereby, in the circular accelerator that accelerates charged particle beam while increasing an orbit radius by applying a radiofrequency wave in a main magnetic field, the high precision control on extraction of the charged particle beam from the circular accelerator is achieved.

In an embodiment, the present disclosure pertains to a method of determining optimal parameters for application of light from a light source to a tissue. In general, the method includes one or more of the following steps of: (1) utilizing an algorithm to generate results related to estimating light flow from the light source into the tissue; and (2) utilizing the results to determine optimal parameters for applying the light source to the tissue. In some embodiments, the method of the present disclosure further includes the step of: (3) applying the light source to the tissue using the optimal parameters; and (4) treating a condition associated with the tissue.

A radiotherapy system includes X-ray imaging apparatuses that obtain an X-ray image of the patient on a reference plane, and a position determination apparatus. The position determination apparatus calculates parameters of a region estimation model, using, as input data, a reference fluoroscopic image obtained before radiotherapy, and also using, as teacher data, a reference ROI image obtained with respect to the reference fluoroscopic image before radiotherapy. During radiotherapy, the position determination apparatus estimates a region of interest with respect to the X-ray image and a DRR image, based on the parameters and the X-ray image, determines a degree of matching between the X-ray image and the DRR image for the region of interest while virtually changing a relative position/orientation relationship between a CT image and the reference plane, and determines an amount of deviation in position/orientation between the patient and the CT image.

Methods and systems are disclosed for radiating a moving object. The method may comprise acquiring a plurality of indicators of the phase of a physiological cycle of a patient and a plurality of images of the patient that include a target. Each image may be taken at a different phase of the physiological cycle and may be registered to the phase at which the image was taken. The method may also include identifying the target in each of the plurality of images, calculating a dose of radiation required to treat the target, calculating the number, orientation, and dwell time of one or more radiation beams required to deliver the calculated required dose of radiation to the target, and calculating a position of each of the one or more radiation beams required to achieve the calculated orientation. Each position may be a function of the phase of the physiological cycle to which each of the plurality of images is registered.

A high-energy radiation treatment system can comprise a laser-driven accelerator system, a patient monitoring system, and a control system. The laser-driven accelerator system, such as a laser-driven plasma accelerator or a laser-driven dielectric microstructure accelerator, can be constructed to irradiate a patient disposed on a patient support. The patient monitoring system can be configured to detect and track a location or movement of a treatment volume within the patient. The control system can be configured to control the laser-driven accelerator system responsively to the location or movement of the treatment volume. The system can also include a beam control system, which generates a magnetic field that can affect the radiation beam and/or secondary electrons produced by the irradiation beam. In some embodiments, the beam control system and the patient monitoring system can comprise a magnetic resonance imaging system.

A structure includes a base comprising a first ramp and an opposing, second ramp. The structure further includes a shell frame having an inner surface configured to a shape of a body part and an outer convex surface, wherein the outer convex surface of the shell frame rides upon, and moves relative to, upper surfaces of the first ramp and the second ramp to enable a pitch of the shell frame to be adjusted relative to the base.

A structure includes a base comprising a first ramp and an opposing, second ramp. The structure further includes a shell frame having an inner surface configured to a shape of a body part and an outer convex surface, wherein the outer convex surface of the shell frame rides upon, and moves relative to, upper surfaces of the first ramp and the second ramp to enable a pitch of the shell frame to be adjusted relative to the base.

An image calibration method includes capturing and correcting a flood field image for background signal and effects of known image-panel features (dead/bad pixels). The corrected image is processed to separate frequencies characteristic of relative pixel sensitivities from frequencies characteristic of radiation energy fluence. The incident energy fluence has a known maximum in-field energy fluence gradient. A model that describes the incident energy fluence on a detector is generated or received. The corrected image may be modeled at frequencies at or below the maximum in-field energy fluence gradient. A pixel sensitivity matrix (PSM) is generated by adjusting the corrected image with the model of the incident energy fluence on the detector. For example, the corrected image signal may be divided by the model or the model may be subtracted from the corrected image. The PSM may be used to correct additional raw images captured by the detector.

Disclosed herein are variations of megavoltage (MV) detectors that may be used for acquiring high resolution dynamic images and dose measurements in patients. One variation of a MV detector comprises a scintillating optical fiber plate, a photodiode array configured to receive light data from the optical fibers, and readout electronics. In some variations, the scintillating optical fiber plate comprises one or more fibers that are focused to the radiation source. The diameters of the fibers may be smaller than the pixels of the photodiode array. In some variations, the fiber diameter is on the order of about 2 to about 100 times smaller than the width of a photodiode array pixel, e.g., about 20 times smaller. Also disclosed herein are methods of manufacturing a focused scintillating fiber optic plate.

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.