The disclosed subject matter provides compositions and methods for treating dental caries. The composition can include an effective amount of a mannan degrading enzyme. The effective amount of the mannan degrading enzyme can be present to treat dental caries of a subject.

Described herein are oral care compositions comprising a deoxy sugar antimetabolite and methods of inhibiting microbial biofilm formation and/or degrading a microbial biofilm in a subject.

Implant comprising composite powder with microstructured particles, obtained by a process in which large particles are bonded to small particles, wherein the large particles have a mean particle diameter in the range from 10 μm to 10 mm, the large particles comprise at least one polymer, the small particles are arranged on the surface of the large particles and/or are non-homogeneously spread within the large particles, the small particles comprise a calcium salt, the small particles have a mean particle size in the range from 0.01 μm to 1.0 mm,
wherein the particles of the composite powder have a mean particle size d50 in the range from 10 μm to less than 200 μm and the fine fraction of the composite powder is less than 50 vol %. Therefore, the subject matter of the invention further are implants obtained by selective laser sintering of a composition comprising a composite powder, especially as an implant for applications in the field of neuro, oral, maxillary, facial, ear, nose and throat surgery as well as of hand, foot, thorax, costal and shoulder surgery.

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. ##STR00001##
wherein the symbols in the formula are defined below: R.sup.1: e.g., a C1-C6 alkyl group; R.sup.2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R.sup.3: e.g., a C1-C6 alkyl group.

Provided herein are magnetically-responsive, photosensitizer based antimicrobial microemulsions and photodynamic nanoplatforms in which a photosensitizer functionally associated with a plurality of superparamagnetic iron oxide nanoparticles are encapsulated. Also provided are methods and processes utilizing the antimicrobial microemulsions and photodynamic nanoplatforms to treat an oral disease, to reduce a microbial population in a pathogenic oral biofilm and to improve the efficacy of a photosensitizer during an antimicrobial photodynamic therapy treatment of an oral disease.

Provided herein are magnetically-responsive, photosensitizer based antimicrobial microemulsions and photodynamic nanoplatforms in which a photosensitizer functionally associated with a plurality of superparamagnetic iron oxide nanoparticles are encapsulated. Also provided are methods and processes utilizing the antimicrobial microemulsions and photodynamic nanoplatforms to treat an oral disease, to reduce a microbial population in a pathogenic oral biofilm and to improve the efficacy of a photosensitizer during an antimicrobial photodynamic therapy treatment of an oral disease.

An oral cavity care method uses a fine ozone bubble liquid, wherein a stock solution of the fine ozone bubble liquid has ozone gas concentration of 100 ppm or more, even if ozone gas concentration of the fine ozone bubble liquid is diluted to 4 ppm or less, the fine ozone bubble liquid has a sterilizing action, the fine ozone bubble liquid has ozone gas concentration of 4 ppm or more after frozen storage for one year or more, and in addition to the sterilizing action, the fine ozone bubble liquid has an odor component decomposition action and an antiviral action.

The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Pharmaceutical compositions comprising plasminogen or a biologically active variant thereof are disclosed. In an embodiment, the composition comprises a tonicity modifier, a bulking agent, and a stabilising agent and has a pH of about 3.0 to about 10.0. In another embodiment, the composition contains an amount of particles in suspension equal to or greater than 10 μm which is lower than 6000 particles per 100 ml, and preferably lower than 2000 particles per 100 ml. Uses of these compositions as a medicament is contemplated. Various therapeutic uses of these pharmaceutical compositions is also contemplated.

In various embodiments a dental varnish system having improved peptide release and fluoride release properties is provided. In various embodiments a dental varnish system that provides release of an antimicrobial peptide, or specifically targeted antimicrobial peptide (STAMP), e.g., the peptide C16G2, is provided, with or without a fluoride. In various embodiments, a dental varnish system that provides release of a fluoride, with or without an antimicrobial peptide or STAMP is provided. In certain embodiments the dental varnish system comprises a first component that is a dry powder, said first component comprising a an antimicrobial peptide, with or without a fluoride, and a bulking agent, and a second component that is a fluid, said second component comprising a varnish solution, where combination of said first component with said second component provides a varnish formulation for application to the surface of a tooth.