Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury, pulmonary fibrosis (idiopathic), bleomycin induced pulmonary fibrosis, mechanical ventilator induced lung injury, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiolitis obliterans after lung transplantation and lung transplantation-induced acute graft dysfunction, including treatment, prevention or prevention of progression of primary graft failure, ischemia-reperfusion injury, reperfusion injury, reperfusion edema, allograft dysfunction, pulmonary reimplantation response, bronchiolitis obliterans after lung transplantation and/or primary graft dysfunction (PGD) after organ transplantation, in particular in lung transplantation, comprising down-regulating the TLR2 gene or both the TLR2 gene and TLR4 gene. Provided herein are compositions, methods and kits for treating lung diseases, disorders and injury.

The present invention is directed to therapeutic multifunctional immature dental pulp stem cells (IDPSCs), and IDPSCs multi-lineage compositions. The invention is further directed to the use of IDPSCs and compositions to reduce the risk of and/or treat degenerative diseases or for other medicinal and aesthetic purposes.

Supplements for maintaining a healthy immune response include one or more extracts from rosemary, turmeric, green tea, ginger, holy basil, oregano, boswellia, black currant, and clove. The supplements may include an extract of thyme. The supplements may exclude anti-inflammatory drugs and certain anti-inflammatory herbs.

The present invention relates in a first aspect to a pharmaceutical composition and in a second aspect to a therapeutic combination for use in the treatment or prevention of vitamin and mineral deficiencies in patients which have been subjected to gastric bypass-surgery. A third aspect of the present invention relates to a pharmaceutical composition as such.

Provided are a method of extracting saponin which is the physiologically active component of akebia quinata with high efficiency, by sequentially subjecting to a) adding akebia quinata flesh to akebia quinata seeds and performing aging; and b) extracting with alcohol, a method of further improving saponin extraction efficiency by adding ginger, and a food composition containing the extract produced by this method. Higher added value may be created by improving the saponin extraction efficiency from akebia quinata seeds using akebia quinata flesh which has not been utilized when extracting saponin.

Compositions for transdermal delivery of an active agent and methods for using such compositions are described herein.

The present disclosure relates to parenteral nutrition formulations, including ready-to-use parenteral nutrition formulations which are reconstituted from multi-chamber containers and amino acid formulations. More particularly, the present disclosure is directed to formulations comprising butyrate derivatives, specifically arginine butyrate, for use with adult or pediatric patients. The disclosure further provides for methods of reducing or preventing systemic and local inflammation of patients receiving parenteral nutrition, and methods of maintaining or ameliorating their systemic immunity and local immunity, as well as the patients' gut barrier functions.

Provided herein are pharmaceutical compositions, formulations and dosage forms comprising variants of fibroblast growth factor 19 (FGF19) proteins and peptide sequences (and peptidomimetics) and fusions of FGF19 and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), and variants of fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics). Methods of using the pharmaceutical compositions, formulations and dosage forms are also provided herein.

The present invention a polyphenol complexes with amino acids, peptides, proteins, glycosaminoglycans, polysaccharides, mucopolysaccharide, disaccharides, monosaccharides, amino sugars, glycol-proteins, DNA/RNA oligonucleotides, mRNA, siRNA, antibodiesor other micro- or macro biomolecules.

An object of the present invention is to provide an agent for improving red blood cell function which has both high antioxidant action and high ability to migrate into red blood cells, and can effectively protect red blood cells against oxidative stress. Cucurbitaxanthin A and/or a derivative thereof has an ability to migrate into red blood cells significantly higher than that of the other carotenoids reported to migrate into red blood cells, and can effectively protect red blood cells against oxidative stress, and thus, is effective as an agent for improving red blood cell function.