The invention relates to various compositions for improving exercise performance and/or recovery. The invention also relates to methods of using these compositions and kits including these compositions to improve exercise performance and/or recovery.

Methods, compositions, and kits for adjunctive therapy using 25-hydroxyvitamin D are disclosed. The 25-hydroxyvitamin D may be administered with an agent that increases the risk of hypocalcemia, such as cinacalcet or a salt thereof, and/or an anticancer agent. The adjunctive therapy is effective to treat and prevent iatrogenic hypocalcemia and/or secondary hyperparathyroidism, as well as delay cancer progression and the time to a post-treatment skeletal related event.

The present disclosure provides certain angular tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinpathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Certain embodiments of the invention provide a method for improving maternal and/or offspring health, comprising administering an effective amount of a nicotinamide adenine dinucleotide (NAD) precursor to a female mammal (e.g., pregnant or lactating female mammal).

Methods of screening cancerous cells for nutritional weaknesses and methods of treating cancer nutritionally are disclosed. Certain cancers depend on being supplied with one or more nutrients that are non-essential for normal cells. In particular, the invention relates to methods of treating cancer by identifying nutritional weaknesses of cancer cells and using nutritional therapy to suppress cancer by putting a subject on a diet that deprives cancerous cells of a nutrient needed for cancer proliferation and growth. Nutritional therapy can be used to enhance the effectiveness of current cancer treatments.

Devices, systems, and methods described herein can provide a simulated fluid environment similar to the mother's womb to recreate an ideal or more familiar environment for infants who are born before their ideal due date. In some embodiments, the premature infant amniotic bath incubator can comprise an incubating tank with synthetic or simulated amniotic fluid, a heating element(s), a temperature sensor(s), and/or thermostat(s) for temperature regulation.

There is a need to increase protein synthesis in subjects receiving parenteral nutrition. The present disclosure provides oxidized glutathione (GSSG) or a GSSG analog as a supplement for parenteral nutrition to maintain, promote or increase protein synthesis in a subject receiving parenteral nutrition. The present disclosure also provides a parenteral nutrition solution as well as therapeutic uses of the parenteral nutrition supplement or the parenteral nutrition solution.

There is a need to increase protein synthesis in subjects receiving parenteral nutrition. The present disclosure provides oxidized glutathione (GSSG) or a GSSG analog as a supplement for parenteral nutrition to maintain, promote or increase protein synthesis in a subject receiving parenteral nutrition. The present disclosure also provides a parenteral nutrition solution as well as therapeutic uses of the parenteral nutrition supplement or the parenteral nutrition solution.

The subject invention provides microbe-based products, as well as their use, for enhancing aquaculture. In particular, the subject invention provides materials and methods for producing healthy and high quality farmed fish by applying yeast and/or bio surfactant-based compositions to a fish farm. In one embodiment, the subject invention improves the environment in which the fish are farmed. In another embodiment, the subject invention provides a highly nutritious fish feed, as well as methods of feeding fish at low cost.

A nutrition formula milk powder for infants after congenital heart disease surgery or non-cardiac surgery and critically ill infants in intensive care. The nutrition formula milk powder has an energy to protein ratio of 55-60 kcal:3.0-4.0 g/100 ml.