In some examples, a machine for generating optically variable image elements on a substrate includes a printing substrate infeed and a printing unit including a printing mechanism by which a substrate guided on a transport path is printed with a coating agent containing magnetic or magnetizable particles. A device for aligning the magnetic or magnetizable particles includes a first alignment device in the transport path and a further alignment device arranged upstream therefrom. During normal operation, the further alignment device is fixed to a frame at the transport path. The further alignment device includes a plurality of magnets that are spaced apart from one another transversely to the transport direction and, during operation, remain stationary. The number of magnets included in the further alignment device correspond to a number of columns of image-producing print motifs or groups of image-producing print motifs around a circumference of a forme cylinder.

A device is provided for aligning magnetic or magnetizable particles, which are contained in a coating that is applied to a first side of a web-type or a sheet-type substrate. An application device is arranged in the transport path of the substrate, by the use of which, the coating is applied or is applicable to the first side of the substrate, in at least one application site. A first cylinder, which is embodied as a magnetic cylinder, is arranged in the transport path of the substrate to be transported downstream of the application device and comprises a plurality of elements creating a magnetic field in the region of the outer periphery of the first cylinder. Another cylinder, which is embodied as a magnetic cylinder, is arranged in the transport path of the substrate to be transported and comprises a plurality of elements creating a magnetic field in the region of the outer periphery of that cylinder. A drying device or an hardening device is arranged on the transport path between a site of a winding-on of the substrate on the first cylinder and a site of a winding-on of the other cylinder. The first cylinder, which is embodied as the magnetic cylinder, is arranged in the transport path of the substrate to be transported on the second side thereof. The drying or the hardening device is oriented in the transport path of the substrate to be transported on the first side thereof.

A cylinder is usable, in particular, for aligning magnetic of magnetizable particles, which are contained in a coating medium that is applied to a first side of a web-like or a sheet-like substrate, which cylinder, in the region of its outer circumference, has a plurality of elements effecting a magnetic field, magnetic elements for short. The magnetic elements are arranged in or on a plurality of ring elements that are spaced axially apart from one another and that are positionable in the axial direction on a shaft, in or on which ring elements, in turn, a plurality of magnetic elements are respectively arranged one after the other in the circumferential direction. At least two adjacent ring elements, each have a covering element, forming a part of the cylindrical lateral surface of the cylinder and extending in the circumferential direction, at least over the circumferential region populated with magnetic elements. The covering elements of two ring elements adjacent to each other have, on their sides facing each other in the axial direction, a plurality of projections alternating in the circumferential direction with recesses and offset in a circumferential direction in such a way that, during a relative movement of the two ring elements towards each other, the projections on the covering element of one ring element engage, in the manner of teeth, in corresponding recesses of the other ring element, and, as seen in the circumferential direction, can overlap. A security paper printing machine, having such a cylinder, is also disclosed.

A system for the replacement of sleeves that can be slipped on arbors of ink transfer rollers of at least printing machine has a storage device, in which the sleeves not being, used in current ink transfer can be stored, and a transport device, with which several sleeves can be transported to the printing machine. The system has a transfer device the facilitates the transfer of the sleeves between the storage device and/or the transport device and the arbors of the ink transfer rollers, and/or between the storage device and the transport device.

A system for the replacement of sleeves that can be slipped on arbors of ink transfer rollers of at least printing machine has a storage device, in which the sleeves not being, used in current ink transfer can be stored, and a transport device, with which several sleeves can be transported to the printing machine. The system has a transfer device the facilitates the transfer of the sleeves between the storage device and/or the transport device and the arbors of the ink transfer rollers, and/or between the storage device and the transport device.

The invention provides for the use of pharmaceutical compositions comprising a thiazolide in the stimulation of the immune system in a subject in need thereof, thereby preventing and/or treating viral diseases, cancer and diseases caused by intracellular protozoan infections.

The invention provides for the use of pharmaceutical compositions comprising a thiazolide in the stimulation of the immune system in a subject in need thereof, thereby preventing and/or treating viral diseases, cancer and diseases caused by intracellular protozoan infections.

An apparatus and method for use in generating a print job for an offset printing apparatus. The method comprising determining a print job to be printed on the offset printer comprises an odd number of separations, and in response to determining that the print job comprises an odd number of separations, alternating a print order of at least two separations between odd and even pages of the print job.

An apparatus and method for use in generating a print job for an offset printing apparatus. The method comprising determining a print job to be printed on the offset printer comprises an odd number of separations, and in response to determining that the print job comprises an odd number of separations, alternating a print order of at least two separations between odd and even pages of the print job.

A system for replacement of sleeves that can be slipped on arbors of Wei y transfer rollers of a printing machine has a storage device, in which the sleeves, which are not used in cl current ink transfer, can be stored, and transport devices, with which several sleeves can be transported to the printing machine, Devices for the transfer of the sleeves with which the sleeves can be transported between the storage device, the transport devices, an, the arbors of the ink transfer rollers include devices for receiving the sleeves, which are associated with a robotic arm such that the devices for receiving the sleeves have three degrees of freedom for translation and are rotatable about at least two axes of rotation.