The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

The present invention provides: a feed for reducing lipid peroxide or improving meat quality in a tissue in an edible portion of a domestic animal, the feed comprising a spore-bearing lactic acid bacterium and/or a spore-bearing thermophilic bacterium not corresponding to the spore-bearing lactic acid bacterium; and a food for reducing lipid peroxide in a human body, the food comprising a spore-bearing lactic acid bacterium and/or a spore-bearing thermophilic bacterium not corresponding to the spore-bearing lactic acid bacterium.

The present invention provides: a feed for reducing lipid peroxide or improving meat quality in a tissue in an edible portion of a domestic animal, the feed comprising a spore-bearing lactic acid bacterium and/or a spore-bearing thermophilic bacterium not corresponding to the spore-bearing lactic acid bacterium; and a food for reducing lipid peroxide in a human body, the food comprising a spore-bearing lactic acid bacterium and/or a spore-bearing thermophilic bacterium not corresponding to the spore-bearing lactic acid bacterium.

The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the TMPRSS6 gene, and methods of using such dsRNA compositions to inhibit expression of TMPRSS6.

Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical compositions contain crosslinked amine polymers and may be used, for example, to treat diseases or other metabolic conditions in which removal of protons and/or chloride ions from the gastrointestinal tract would provide physiological benefits such as normalizing serum bicarbonate concentrations and the blood pH in an animal, including a human.

Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical compositions contain crosslinked amine polymers and may be used, for example, to treat diseases or other metabolic conditions in which removal of protons and/or chloride ions from the gastrointestinal tract would provide physiological benefits such as normalizing serum bicarbonate concentrations and the blood pH in an animal, including a human.

The present invention discloses pharmaceutical-grade ferric organic compounds having enhanced dissolution rate. These ferric organic compounds, including but are not limited to ferric citrate, are useful for treating chronic kidney disease.

p-phenylenediamine derivatives as potassium channel regulators and preparation methods and medical applications thereof. A compound represented by general formula A or a pharmaceutically acceptable salt thereof. A preparation method of the compound and a use of the same as a potassium channel opener.

Antibody molecules that specifically bind to FGF23 are disclosed. The antibody molecules can be used to treat, prevent, and/or diagnose disorders, such as FGF23-associated disorders.

The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of symptoms of a disease selected from the group consisting of: Ebola virus infection, HIV infection, ataxia, environmental enteropathy, cancer, hangover, inflammatory disease, and porcine epidemic diarrhea. In preferred embodiments, the composition includes a combination of one or more amino acids selected from the group comprising lysine, aspartic acid, glycine, isoleucine, threonine, tyrosine, valine, tryptophan, asparagine and/or serine.