The present disclosure relates to agents, compositions targeting to von Willebrand factor (VWF). The VWF targeting agents are synthetic polynucleotides, including VWF binding agents and their reversal agents. The VWF binding agents are VWF binding aptamers that bind to and inhibit the VWF activities. The VWF binding agents can be reversed using reversal agents to reverse the inhibitory effect and thereby restore VWF activities. The disclosure further provides methods for regulating the activities of VWF, thereby modulating VWF mediated platelet functionality, such as thrombosis. the present VWF targeting agents may be used for preventing thrombus formation and treating thrombotic disorders.

The present disclosure relates to agents, compositions targeting to von Willebrand factor (VWF). The VWF targeting agents are synthetic polynucleotides, including VWF binding agents and their reversal agents. The VWF binding agents are VWF binding aptamers that bind to and inhibit the VWF activities. The VWF binding agents can be reversed using reversal agents to reverse the inhibitory effect and thereby restore VWF activities. The disclosure further provides methods for regulating the activities of VWF, thereby modulating VWF mediated platelet functionality, such as thrombosis. the present VWF targeting agents may be used for preventing thrombus formation and treating thrombotic disorders.

An antithrombotic composition containing an extract of Vespa velutina nigrithorax as an active ingredient, and more particularly, a pharmaceutical composition and a health functional food for preventing, ameliorating or treating thrombosis by inhibition of blood coagulation and inhibition of platelet aggregation, which contain an ethyl acetate fraction of an extract of Vespa velutina nigrithorax as an active ingredient. The extract exhibits antithrombotic activity by inhibiting platelet aggregation while exhibiting strong anticoagulant activity by inhibiting thrombosis-related enzymes and blood clotting factors. Also, the extract has no human erythrocyte hemolytic activity, has excellent heat stability, and the thrombosis-related enzyme and blood clotting factor inhibitory effects thereof are not lost even under an acidic condition of pH 2 and in plasma.

An antithrombotic composition containing an extract of Vespa velutina nigrithorax as an active ingredient, and more particularly, a pharmaceutical composition and a health functional food for preventing, ameliorating or treating thrombosis by inhibition of blood coagulation and inhibition of platelet aggregation, which contain an ethyl acetate fraction of an extract of Vespa velutina nigrithorax as an active ingredient. The extract exhibits antithrombotic activity by inhibiting platelet aggregation while exhibiting strong anticoagulant activity by inhibiting thrombosis-related enzymes and blood clotting factors. Also, the extract has no human erythrocyte hemolytic activity, has excellent heat stability, and the thrombosis-related enzyme and blood clotting factor inhibitory effects thereof are not lost even under an acidic condition of pH 2 and in plasma.

The present inventors produced a variety of bispecific antibodies that specifically bind to both F. IX/F. IXa and F. X, and functionally substitute for F. VIIIa, i.e., have a cofactor function to promote F. X activation via F. IXa. Among these antibodies, the antibody A44/B26 reduced coagulation time by 50 seconds or more as compared to that observed when the antibody was not added. The present inventors produced a commonly shared L chain antibody from this antibody using L chains of A44, and showed that A44L can be used as commonly shared L chains, although the activity of the resulting antibody is reduced compared to the original antibody (A44HL-B26HL). Further, with appropriate CDR shuffling, the present inventors successfully produced highly active multispecific antibodies that functionally substitute for coagulation factor VIII.

The present invention relates generally to the field of recombinant fatty acid synthesis, particularly in transgenic plants. The application describes genes involved in fatty acid synthesis and provides methods and vectors for the manipulation of fatty acid composition of plant oils. In particular, the invention provides constructs for achieving the integration of multiple heterologous genes involved in fatty acid synthesis into the plant genome, such that the resulting plants produce altered levels of polyunsaturated fatty acids. Also described are methods for enhancing the expression of fatty acid biosynthesis enzymes by co-expressing a silencing suppressor within the plant storage organ.

The invention relates to stable and low viscous (<50 cP) protein containing compositions, in particular, but not exclusively stable antibody containing compositions and to the use of said stable proteins in therapy, in particular for the subcutaneous delivery of said stable protein.

Plasma kallikrein binding proteins and methods of using such proteins are described.

The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a cardiovascular disease in an individual using such pharmaceutical compositions.

The present invention relates to substituted imidazopyridazine derivatives of Formula (I)

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wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3Kβ inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.