A61P13/12

PROCESS FOR KIDNEY CELL MANUFACTURE AND TREATMENT

Embodiments described herein relate to a method for preparing cultured cells, the method comprising: obtaining kidney tissue from a human subject; mechanically dissociating the tissue; subjecting the tissue to enzymatic digestion; incubating the tissue with media in a cell culture plate to form cultured cells.

PROCESS FOR KIDNEY CELL MANUFACTURE AND TREATMENT

Embodiments described herein relate to a method for preparing cultured cells, the method comprising: obtaining kidney tissue from a human subject; mechanically dissociating the tissue; subjecting the tissue to enzymatic digestion; incubating the tissue with media in a cell culture plate to form cultured cells.

COMPOSITIONS AND METHODS FOR TREATING RENAL INJURY
20230052363 · 2023-02-16 ·

A method for preventing or treating renal disorder, disease, and/or injury includes administering to the subject and/or kidney a therapeutically effective amount of a 15-PGDH inhibitor.

COMPOSITIONS AND METHODS FOR TREATING RENAL INJURY
20230052363 · 2023-02-16 ·

A method for preventing or treating renal disorder, disease, and/or injury includes administering to the subject and/or kidney a therapeutically effective amount of a 15-PGDH inhibitor.

Methods and compositions for immunomodulation

Provided are cells containing exogenous antigen and uses thereof.

Compounds for inducing tissue formation and uses thereof
11578110 · 2023-02-14 · ·

The present disclosure provides peptides, or variants or analogs thereof, with between 8 and 30 amino acids, having growth factor receptor-binding capability, wherein the RMSD value of the structure coordinates of said peptide, variant or analog thereof with respect to PEPREF is 2.45 Å (Angstroms) or less.

Combination therapy for the treatment of diabetes

The present invention is directed to co-therapy and methods for the treatment and prevention of glucose-related disorders such as Type 2 diabetes mellitus and Syndrome X. The present invention is further directed to pharmaceutical compositions for the co-therapy and methods described herein.

Compounds for the prevention and treatment of diseases and the use thereof

Aspects of the invention relate to novel synthetic compounds having binding affinity with galectin proteins.

Compounds for the prevention and treatment of diseases and the use thereof

Aspects of the invention relate to novel synthetic compounds having binding affinity with galectin proteins.

Stable and soluble antibodies inhibiting TNFα
11578123 · 2023-02-14 · ·

The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity. The antibodies are designed for the diagnosis and/or treatment of TNF-mediated disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of the antibodies in medicine are also described.