Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.

The present invention relates to the use of a combination of a yeast of the species Saccharomyces cerevisiae, resveratrol and a curcuma extract, for use in the management of a subject who has endometriosis or is susceptible to endometriosis. The combination according to the invention may be used in the treatment or prevention of endometriotic lesions in a subject who has endometriosis or is susceptible to endometriosis, for example to slow the development or to reduce the endometriotic lesions. It may also be used in the treatment or prevention of one or more symptoms or disorders associated with endometriosis. The invention also relates to pharmaceutical or nutraceutical compositions and kits based on said combination.

The present invention relates to the use of a combination of a yeast of the species Saccharomyces cerevisiae, resveratrol and a curcuma extract, for use in the management of a subject who has endometriosis or is susceptible to endometriosis. The combination according to the invention may be used in the treatment or prevention of endometriotic lesions in a subject who has endometriosis or is susceptible to endometriosis, for example to slow the development or to reduce the endometriotic lesions. It may also be used in the treatment or prevention of one or more symptoms or disorders associated with endometriosis. The invention also relates to pharmaceutical or nutraceutical compositions and kits based on said combination.

Hedgehog pathway modulators, such as hedgehog pathway activators or inhibitors, and the use of such modulators to modulate FSH signaling are described.

The present invention provides, inter alia, methods for treating or ameliorating an effect of a solid tumor present in a human. These methods include administering intratumorally to the human a unit dose of C. novyi, preferably C. novyi NT, colony forming units (CFUs), which contains about 1×10.sup.3-1×10.sup.7 CFUs suspended in a pharmaceutically acceptable carrier or solution. Methods for debulking a solid tumor present in a human, methods for ablating a solid tumor present in a human, a method for microscopically precise excision of tumor cells in a human, methods for treating or ameliorating an effect of a solid tumor that has metastasized to one or more sites in a human, unit doses of C. novyi, preferably C. novyi NT, CFUs, and kits for treating or ameliorating an effect of a solid tumor present in a human are also provided.

A composition and method for using a composition, the composition having at least two compounds, each of which induces indolamine 2,3-dioxygenase, for the treatment of an autoimmune disorder or disease or immune rejection of transplants or gene therapeutically modified cells, wherein the inducers have different mechanism of action and wherein the composition gives rise to a synergistic effect on the IDO levels.

Novel compounds of Formula I ##STR00001##
and their use in therapeutic treatments.

The present invention relates to improved assisted reproductive technology using highly purified menotropin (HP-hMG) to stimulate follicle development in controlled ovarian stimulation, particularly in women at risk of a high ovarian response to controlled ovarian stimulation.

The invention provides substituted pyrazolo[1,5-a]pyrimidinyl carboxamide and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted pyrazolo[1,5-a]pyrimidinyl carboxamide compounds described herein include 2-heterocyclyl-4-alkyl-pyrazolo[1,5-a]pyrimidine-3-carboxamide compounds and variants thereof.

Preparations including FSH, for example recombinant FSH, for use in the treatment of infertility.