The invention relates to compositions for use in the treatment or prevention of pathogenic infections, rosacea, eczema and psoriasis in humans or animals. The compositions of the invention are also useful in the healing of wounds in a human or animal, and for killing or inactivating viruses on a surface.

The present invention provides methods for improving or accelerating wound healing in a subject comprising administering to a wound of the subject in need thereof an agent that suppresses expression of a clock gene, wherein the clock gene is neuronal PAS domain protein 2 (Npas2). This invention also relates to methods for regenerating alveolar bone, regenerating connective tissue at a wound site, and for decreasing wound area size comprising administering to a bone loss site or a wound site, in particular, an open wound site, of a subject an agent that suppresses expression of Npas2.

The present invention provides methods for improving or accelerating wound healing in a subject comprising administering to a wound of the subject in need thereof an agent that suppresses expression of a clock gene, wherein the clock gene is neuronal PAS domain protein 2 (Npas2). This invention also relates to methods for regenerating alveolar bone, regenerating connective tissue at a wound site, and for decreasing wound area size comprising administering to a bone loss site or a wound site, in particular, an open wound site, of a subject an agent that suppresses expression of Npas2.

There is provided a method for promoting epithelium repair in a subject, the method comprising administering to the subject a therapeutically effective amount of an activator of PI3K/Akt signalling.

Anti-aging cosmetic compositions prepared from conditioned medium of adipose-derived stem cells are provided. The cosmetic compositions are preferably ready-to-mix compositions, comprising two separate components: a protein component in a dried form that serves as the cosmetically active ingredient of the product, comprising a protein fraction purified from an adipose-derived stem cell conditioned medium; and a reconstitution component, for reconstituting the lyophilized protein component just before application to the skin.

The embodiments of the present disclosure provide a manufacturing method of mitochondria-rich plasma. The mitochondria-rich plasma can increase the cell viability of damaged cells, decrease the cellular senescence level, repair the oxidative damage of cells, and relieve the inflammation of hair follicles so as to achieve the purpose of promoting hair regrowth.

Aspects of the present invention relate inter alia to compositions which may have utility as anti-microbials. Such antimicrobial compositions may be for use in promoting wound healing and/or the treatment of microbial infections. In certain embodiments, the invention relates to an antimicrobial composition and/or combinations comprising copper gluconate and zinc gluconate which may be for use in treating and/or preventing infections and/or promoting wound healing. Certain aspects of the present invention further elate to an antimicrobial composition and/or device comprising copper gluconate, zinc gluconate and Lactobacillus plantarum for use in treating infections and/or promoting wound healing. Also encompassed by the present invention are methods of treating microbial and/or fungal infections in a subject, for example infections of the genital tract. Aspects of the present invention include a composition comprising a zinc salt and a copper salt, wherein the zinc salt is zinc gluconate and the copper salt is copper gluconate.

The invention discloses a polypeptide for topical treatment on skin damages resulting from various causes such as burns, wounds or cuts. The polypeptide topical drugs in different dosage forms have good therapeutic effect on scald models and trauma models of animals with little toxic and side effects, and is an innovative drug with good development prospects, and is effective in topical application in treating skin damages resulting from various causes such as burns, wounds or cuts; safe; low toxic and quality controllable.

The invention discloses a polypeptide for topical treatment on skin damages resulting from various causes such as burns, wounds or cuts. The polypeptide topical drugs in different dosage forms have good therapeutic effect on scald models and trauma models of animals with little toxic and side effects, and is an innovative drug with good development prospects, and is effective in topical application in treating skin damages resulting from various causes such as burns, wounds or cuts; safe; low toxic and quality controllable.

The present invention relates to a cord blood plasma-derived exosome or a mimetic thereof and a pharmaceutical use thereof. More particularly, the present invention provides the use of a human cord blood plasma-derived exosome or an exosome mimetic that mimics the proteomic profile of the cord blood plasma-derived exosome for the improvement, prevention or treatment of various autoimmune diseases or wound healing.