The present invention relates to a cord blood plasma-derived exosome or a mimetic thereof and a pharmaceutical use thereof. More particularly, the present invention provides the use of a human cord blood plasma-derived exosome or an exosome mimetic that mimics the proteomic profile of the cord blood plasma-derived exosome for the improvement, prevention or treatment of various autoimmune diseases or wound healing.

The present invention relates to the field of caspase inhibition. More specifically, the present invention provides compositions and methods utilizing caspase inhibitors to enhance injury repair and to treat bacterial and viral infections. In a specific embodiment, a method for treating a bacterial infection and skin lesions in a patient comprises the step of administering to the patient an effective amount of a caspase inhibitor.

The present invention relates to the field of caspase inhibition. More specifically, the present invention provides compositions and methods utilizing caspase inhibitors to enhance injury repair and to treat bacterial and viral infections. In a specific embodiment, a method for treating a bacterial infection and skin lesions in a patient comprises the step of administering to the patient an effective amount of a caspase inhibitor.

Compositions and methods are provided for treating burns to minimize hyperkalemia, hyponatremia, blistering, and pain by externally applying gel mixture on burn areas from onset of burn shock. The substrate is a gel mixture containing concentrated sodium ion to create a concentration gradient, allowing in situ diffusion of sodium ion (in vitro) into blister, edema, and extracellular fluids (in vivo) to reduce hyponatremia and (in situ), delivering pH control constituents in vivo to prevent initial acidosis, and minimizing subsequent alkalosis and normalizing SID while simultaneously in situ expelling potassium ions in vitro from the same fluids transdermally while restoring the normal homeostasis condition in the human body. The in situ restoration of homeostasis and electrophysiological conditions also brings blister minimization and pain relief while retarding transcapillary vascular fluid loss to defend kidney and cardiac functions by rectifying transmembrane potential across skeletal, neural, cardiac, and renal cell membranes.

Compositions and methods are provided for treating burns to minimize hyperkalemia, hyponatremia, blistering, and pain by externally applying gel mixture on burn areas from onset of burn shock. The substrate is a gel mixture containing concentrated sodium ion to create a concentration gradient, allowing in situ diffusion of sodium ion (in vitro) into blister, edema, and extracellular fluids (in vivo) to reduce hyponatremia and (in situ), delivering pH control constituents in vivo to prevent initial acidosis, and minimizing subsequent alkalosis and normalizing SID while simultaneously in situ expelling potassium ions in vitro from the same fluids transdermally while restoring the normal homeostasis condition in the human body. The in situ restoration of homeostasis and electrophysiological conditions also brings blister minimization and pain relief while retarding transcapillary vascular fluid loss to defend kidney and cardiac functions by rectifying transmembrane potential across skeletal, neural, cardiac, and renal cell membranes.

Based on the three-dimensional structure of albumin, the inventors have designed variant polypeptides (muteins) which have one or more cysteine residues with a free thiol group (hereinafter referred to as “thio-albumin”). The variant polypeptide may be conjugated through the sulphur atom of the cysteine residue to a conjugation partner such as a bioactive compound.

The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a polypeptide; viruses comprising the recombinant nucleic acids; compositions comprising the recombinant nucleic acids and/or viruses; methods of their use; and articles of manufacture or kits thereof.

The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a polypeptide; viruses comprising the recombinant nucleic acids; compositions comprising the recombinant nucleic acids and/or viruses; methods of their use; and articles of manufacture or kits thereof.

A method for treating a skin wound of a subject is described. The method includes contacting the skin wound with a therapeutically effective amount of a wound healing composition comprising glycoprotein nonmelanoma clone B (GPNMB) protein, an active peptide fragment thereof, a GPNMB analog, a GPNMB potentiating agent, or a combination thereof.

A method for treating a skin wound of a subject is described. The method includes contacting the skin wound with a therapeutically effective amount of a wound healing composition comprising glycoprotein nonmelanoma clone B (GPNMB) protein, an active peptide fragment thereof, a GPNMB analog, a GPNMB potentiating agent, or a combination thereof.