The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorders affecting hair growth, such as baldness or alopecia.

The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorders affecting hair growth, such as baldness or alopecia.

Present invention discloses particular peptide sequences of formula (I); (R1).sub.(m)-Xaa.sub.1IXaa.sub.2T(Q).sub.(p)(R2).sub.(n) (I) (SEQ ID NO: 1); wherein R.sup.1, m, p, n, Xaa.sub.1, Xaa.sub.2, and R.sup.2 have particular meanings, or pharmaceutically or veterinary acceptable salts of these peptides that are effective in the prevention and/or treatment of mammal hair loss. Invention also relates to particular topical pharmaceutical, nutraceutical or veterinary compositions with the peptides of formula (I).

Present invention discloses particular peptide sequences of formula (I); (R1).sub.(m)-Xaa.sub.1IXaa.sub.2T(Q).sub.(p)(R2).sub.(n) (I) (SEQ ID NO: 1); wherein R.sup.1, m, p, n, Xaa.sub.1, Xaa.sub.2, and R.sup.2 have particular meanings, or pharmaceutically or veterinary acceptable salts of these peptides that are effective in the prevention and/or treatment of mammal hair loss. Invention also relates to particular topical pharmaceutical, nutraceutical or veterinary compositions with the peptides of formula (I).

An object of the present invention is to provide an enzyme-treated milk product, a method for preparing the same, a composition thereof comprising a pharmaceutical composition, and a product thereof comprising a pharmaceuticals. The enzyme-treated milk product can be obtained by a method for producing an enzyme-treated milk product including a step for bringing milk into contact with β-galactosidase.

A use of plant exosomes as a product having the effect of enhancing viability and, by stimulating the hair follicles, enhancing hair growth in skin cells. The plant exosomes are used to revitalize and strengthen unhealthy skin and hair that have lost their vitality, to stop hair loss, to provide faster hair growth by stimulating hair follicles, and to provide a regulating effect in improving the effects such as wrinkles and age spots caused by aging skin cells. The plant exosomes are isolated from single, double, or triple combinations of plants selected from a group consisting of pineapple plant, garlic plant, and pomegranate plant. For example, a triple combination includes 1 ng-1 mg of the plant exosomes isolated from the pineapple plant, 1 ng-10 μg of the plant exosomes isolated from the garlic plant, and 1 ng-1 mg of plant exosomes isolated from the pomegranate plant.

A use of plant exosomes as a product having the effect of enhancing viability and, by stimulating the hair follicles, enhancing hair growth in skin cells. The plant exosomes are used to revitalize and strengthen unhealthy skin and hair that have lost their vitality, to stop hair loss, to provide faster hair growth by stimulating hair follicles, and to provide a regulating effect in improving the effects such as wrinkles and age spots caused by aging skin cells. The plant exosomes are isolated from single, double, or triple combinations of plants selected from a group consisting of pineapple plant, garlic plant, and pomegranate plant. For example, a triple combination includes 1 ng-1 mg of the plant exosomes isolated from the pineapple plant, 1 ng-10 μg of the plant exosomes isolated from the garlic plant, and 1 ng-1 mg of plant exosomes isolated from the pomegranate plant.

Compositions and methods of promoting wound healing in a human by administering to the human mesenchymal stem cells in an effective amount.

The present invention refers to a new enzymatic process for obtaining 17α-monoesters of cortexolone and/or its 9, 11-dehydroderivatives starting from the corresponding 17α,21-diesters which comprises an enzymatic alcoholysis reaction. Furthermore, the present invention refers to new crystalline forms of cortexolone-17α-propionate and 9,11-dehydro-cortexolone 17α-butanoate.

The present invention is directed to compositions and formulations for hair growth. The non-aqueous, preservative-free formulations are useful for the growth of hair, eyebrows and eyelash in a variety of setting. Also provided herein are non-aqueous, preservative-free formulations and methods for the treatment of dry-eye and related symptoms.