The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.

The present invention is directed to methods for treating or ameliorating skin conditions, diabetic conditions, cardiovascular conditions, cancer, infections or metal poisoning, enhancing performance, or providing nutritional support, comprising administering to a subject in need thereof compositions comprising a magnetic dipole stabilized solution (MDSS). The MDSS solution may include additional components and can be provided in a kit.

In one embodiment, the present invention provides a personal care composition, comprising: (i) a compound of Formula (1) at a concentration from 0.0001 wt % to 20 wt % of the composition; ##STR00001## wherein R is selected from the group consisting of C.sub.15-C.sub.23 conjugated dienes, C.sub.15-C.sub.23 hydroxylated mono unsaturated alkenes, and C.sub.15-C.sub.23 hydroxylated alkanes; wherein R1 is selected from the group consisting of H, C.sub.1-C.sub.4 alkyl, —CH.sub.2OH, —CH.sub.2(CH.sub.3)—OH, —[CH.sub.2].sub.4—NH.sub.2, —CH.sub.2—CO.sub.2H, —[CH.sub.2].sub.2—CO.sub.2H, ##STR00002## wherein R3 is —CO.sub.2H; —CH.sub.2CO.sub.2H; —CH.sub.2CH.sub.2CO.sub.2H; and (ii) a cosmetically acceptable carrier.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

A method of preventing contact allergies includes using at least one amphoteric chelating agent which includes a complex based on aluminium and on ethylenediaminetetraacetic acid or the trisodium salt thereof, having the general formula [Al(Y)Bn]c′Dc with B being OH.sup.−, BO.sub.2.sup.− or H.sup.+, Y being a tetracarboxylate which can be protonated four times to form ethylenediaminetetraacetic acid, n being an integer equal to 0, 1, 2 or 3, D being a counterion, preferably Na.sup.+, c being an integer equal to 0, 1, 2 or 3 and c′ being a relative number having the same absolute value as c. A device, a part of which includes the amphoteric chelating agent, is also described.

The present invention provides compositions and methods for treating a dermatological disorder or disease.

Methods of treatment as Janus Kinase inhibitors containing the compound of the invention having the structure:

##STR00001##

or a pharmaceutically acceptable salt thereof, wherein X is N; A is selected from the group consisting of a bond and C═O; R.sub.1 is C.sub.3-C.sub.6 cycloalkyl, wherein said cycloalkyl is further optionally substituted with one or more halo; R.sub.2 is hydrogen; R.sub.3 is hydrogen; R.sub.4 is monocyclic heteroaryl wherein said heteroaryl is optionally substituted with one or more C.sub.1-C.sub.6 alkyl; and, R.sub.5 is hydrogen; and, j is 0 or 1.

Novel polyphenol compositions and methods for the treatment and prevention of radiation dermatitis, eczema, thermal burns, wounds, and certain cancers. The disclosure also relates to methods for the preparation of polyphenol compositions including flavonoid compositions.

The subject invention relates to novel micoparticulate and soluble forms of flavonoids, and their synthesis. The invention also includes novel formulations of such flavonoids. Further, the invention includes novel methods of manufacturing the flavonoid formulations. The invention also relates to a wide variety of applications of the flavonoid formulations.