A combination product comprising a dispensing head (10, 10′) mounted on a top of a container (20, 20′) containing a formulation for nasal administration, and a solidified skin-care balm (50) for application around the nose contained in a balm holder element (30, 30″) located on a bottom (24) of the container (20).

Provided herein is a topical composition comprising tapinarof and methods of treatment of cutaneous adverse effects caused by oncological therapy with the tapinarof composition. The tapinarof compositions of this invention are useful for the treatment, prevention or amelioration of cutaneous and/or mucosal adverse effect caused by oncological therapy selected from chemotherapy, immunotherapy, radiation therapy, targeted therapy, hormone therapy and stem cell transplant therapy.

The present invention is directed to a composition comprising phytoene, phytofluene, and zeta carotene, and methods of using the same, such as for reducing collagen loss.

The present invention relates to a UV blocking composition comprising red algae-derived floridoside and an amine group-containing compound, and a use thereof in a cosmetic material and a pharmaceutical composition.

This invention relates to compounds that treat microbial skin infections. Previously, powered forms of talk were difficult to apply to skin without becoming a lung irritant. Embodiments of the present invention use talc, lanolin, petroleum jelly, sodium lauryl ether sulfate, sodium chloride, water, sodium salicylate, Lauryl ether sulfate, Isopropyl palmitate, propylene glycol, mineral oil, and sodium benzoate.

In an aspect of the present application, a composition for preventing or treating skin damage in skin of a mammalian subject in need thereof can include at least one autophagy promoter and at least one diuretic. The at least one autophagy promoter and the at least one diuretic, in combination, can each be present in an amount sufficient to prevent or treat the skin damage. In another aspect, the present application includes a method for preventing or treating skin damage in skin of a mammalian subject in need thereof whereby the composition can be administered to the subject in a therapeutically effective amount to prevent or treat the skin damage.

An object of the present invention is to provide a novel food material effective for improving skin conditions. The present invention provides a composition for use in improving skin conditions, comprising a Lactococcus bacterium as an active ingredient. Examples of the Lactococcus bacterium include Lactococcus lactis. The skin conditions are skin conditions deteriorated by light exposure, such as an increase in skin redness and a decrease in skin moisture content.

Disclosed is a composition including, per 100% of its mass: a) 60.0% to 75.0% by mass of an organic solvent (OS.sub.1) chosen from 1,2-propanediol, 1,3-propanediol, 1,4-butanediol, 1,3-butanediol, 1,2-butanediol, 2-methyl-2,4-pentanediol, 1,6-hexanediol, 1,8-octanediol, or a mixture of these compounds; b) 0.1% to 2.0% by mass of a composition (ES) including an amount by mass x.sub.1, expressed as mass equivalent of 1-O-(2-caffeoyl)maloyl-3,5-di-O-catfeoylquinic acid, of greater than or equal to 200 mg/g of a compound of general formula (I):

##STR00001##

in which Q.sub.1, Q.sub.2, Q.sub.3, Q.sub.4 and Q.sub.5 represent, independently of each other, a hydroxyl radical or a salt thereof or a radical chosen from caffeoyl, maloyl, caffeoyl maloyl and maloyl caffeoyl radicals, it being understood that at least one of these radicals Q.sub.1, Q.sub.2, Q.sub.3, Q.sub.4 and Q.sub.5 represents neither the —OH radical nor a salt thereof; and c) 20.0% to 35.0% by mass of water. Related treatments are also disclosed.

Disclosed is a composition including, per 100% of its mass: a) 60.0% to 75.0% by mass of an organic solvent (OS.sub.1) chosen from 1,2-propanediol, 1,3-propanediol, 1,4-butanediol, 1,3-butanediol, 1,2-butanediol, 2-methyl-2,4-pentanediol, 1,6-hexanediol, 1,8-octanediol, or a mixture of these compounds; b) 0.1% to 2.0% by mass of a composition (ES) including an amount by mass x.sub.1, expressed as mass equivalent of 1-O-(2-caffeoyl)maloyl-3,5-di-O-catfeoylquinic acid, of greater than or equal to 200 mg/g of a compound of general formula (I):

##STR00001##

in which Q.sub.1, Q.sub.2, Q.sub.3, Q.sub.4 and Q.sub.5 represent, independently of each other, a hydroxyl radical or a salt thereof or a radical chosen from caffeoyl, maloyl, caffeoyl maloyl and maloyl caffeoyl radicals, it being understood that at least one of these radicals Q.sub.1, Q.sub.2, Q.sub.3, Q.sub.4 and Q.sub.5 represents neither the —OH radical nor a salt thereof; and c) 20.0% to 35.0% by mass of water. Related treatments are also disclosed.

A composition is disclosed that includes pure silk fibroin-based protein fragments that are substantially devoid of sericin, wherein the composition has an average weight average molecular weight ranging from about 17 kDa to about 38 kDa, wherein the composition has a polydispersity of between about 1.5 and about 3.0, wherein the composition is substantially homogeneous, wherein the composition between 0 ppm to about 500 ppm of inorganic residuals, and wherein the composition includes between 0 ppm to about 500 ppm of organic residuals.