Provided is a novel compound that is contained in a young watermelon fruit and has an antioxidative effect.

The novel compound that is contained in a young watermelon fruit and is represented by the formula (1) or formula (2) has an antioxidative effect and further has a skin anti-aging effect. Since these compounds are extracts from plants that are naturally edible, they are very safe for human bodies. Therefore, an antioxidative pharmaceutical composition, an antioxidative processed food composition, and an anti-skin aging composition, which contain these compounds as active ingredients, have high utility value as highly safe compositions.

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The present invention concerns a composition comprising a Lycium barbarum extract or Lycium barbarum polysaccharide in combination with a Moringa oleifera extract and a pharmaceutically acceptable carrier. The composition finds application both in the medical field, in the treatment of actinic lesions, precancerous skin lesions, or non-melanoma skin cancer, and in non-therapeutic applications in the treatment of skin damage caused by exposure to the sun's rays, such as photoaging.

Biologically active cannabidiol analogs comprising a compound of the formula ##STR00001##
wherein one of R.sub.1 or R.sub.2 or both is/are the residue of a moiety formed by the reaction of an amino group of the amino acid ester of R.sub.1 or R.sub.2 or both with a dicarboxylic acid or a dicarboxylic acid derivative and the other R.sub.1 or R.sub.2 (in the case of the mono) is the residue of a dicarboxylic acid or dicarboxylic acid derivative or Hydrogen (H), (i.e. underivatized), and salts thereof. These CBD analogs are be useful in pain management in oncology and other clinical settings in which neuropathy is presented. Furthermore, these CBD-analogs are useful in blocking the addictive properties of opiates.

Biologically active cannabidiol analogs comprising a compound of the formula ##STR00001##
wherein one of R.sub.1 or R.sub.2 or both is/are the residue of a moiety formed by the reaction of an amino group of the amino acid ester of R.sub.1 or R.sub.2 or both with a dicarboxylic acid or a dicarboxylic acid derivative and the other R.sub.1 or R.sub.2 (in the case of the mono) is the residue of a dicarboxylic acid or dicarboxylic acid derivative or Hydrogen (H), (i.e. underivatized), and salts thereof. These CBD analogs are be useful in pain management in oncology and other clinical settings in which neuropathy is presented. Furthermore, these CBD-analogs are useful in blocking the addictive properties of opiates.

Biologically active cannabidiol analogs comprising a compound of the formula ##STR00001##
wherein one of R.sub.1 or R.sub.2 or both is/are the residue of a moiety formed by the reaction of an amino group of the amino acid ester of R.sub.1 or R.sub.2 or both with a dicarboxylic acid or a dicarboxylic acid derivative and the other R.sub.1 or R.sub.2 (in the case of the mono) is the residue of a dicarboxylic acid or dicarboxylic acid derivative or Hydrogen (H), (i.e. underivatized), and salts thereof. These CBD analogs are be useful in pain management in oncology and other clinical settings in which neuropathy is presented. Furthermore, these CBD-analogs are useful in blocking the addictive properties of opiates.

Provision of a material, which has activity of inhibiting endothelin-converting enzyme and is effective for skin whitening or antihypertension. An endothelin-converting enzyme inhibitor comprising, as an active ingredient, at least one selected from the group consisting of Hiptage candicans, Piper sarmentosum, Solanum stramonifolium, Anaxagorea luzonensis, Smilax corbularia, Ardisia elliptica, Erythrina suberosa, Dactyloctenium aegyptium, Hopea ferrea and extracts thereof.

Provision of a material, which has activity of inhibiting endothelin-converting enzyme and is effective for skin whitening or antihypertension. An endothelin-converting enzyme inhibitor comprising, as an active ingredient, at least one selected from the group consisting of Hiptage candicans, Piper sarmentosum, Solanum stramonifolium, Anaxagorea luzonensis, Smilax corbularia, Ardisia elliptica, Erythrina suberosa, Dactyloctenium aegyptium, Hopea ferrea and extracts thereof.

Described herein are transdermal formulations and methods of using the same.

A method for improving body shape and improving skin condition using a noni fruit ferment is provided, and the method includes: administrating a composition to a subject in need thereof. The composition includes an effective amount of noni fruit ferment. The noni fruit ferment is prepared by (a) mixing glucose and noni fruit with water for extraction, to obtain a noni fruit broth, and (b) fermenting the noni fruit broth with a plurality of bacteria strains. The bacteria strains include yeast, lactic acid bacteria, and acetic acid bacteria. In step (b), the noni fruit broth and the bacteria strains are irradiated with a red light source with a wavelength of 620 nm to 750 nm. In addition, the noni fruit ferment also has at least one of the following functions: removing free radicals, improving defecation status, and improving gastrointestinal motility.

A method for improving body shape and improving skin condition using a noni fruit ferment is provided, and the method includes: administrating a composition to a subject in need thereof. The composition includes an effective amount of noni fruit ferment. The noni fruit ferment is prepared by (a) mixing glucose and noni fruit with water for extraction, to obtain a noni fruit broth, and (b) fermenting the noni fruit broth with a plurality of bacteria strains. The bacteria strains include yeast, lactic acid bacteria, and acetic acid bacteria. In step (b), the noni fruit broth and the bacteria strains are irradiated with a red light source with a wavelength of 620 nm to 750 nm. In addition, the noni fruit ferment also has at least one of the following functions: removing free radicals, improving defecation status, and improving gastrointestinal motility.