Disclosed is a method for preventing or treating muscular atrophy or sarcopenia, the method comprising administering a composition comprising 2′-fucosyllactose (2′-FL) as an active ingredient to a subject in need thereof. The composition administered to the subject increases the expression of genes related to mitochondrial function enhancement and mitochondrial biosynthesis, and reduces the expression of atrogin-1 and MuRF1 genes, which are markers for muscular atrophy, thereby providing effects of strengthening muscles and preventing muscular atrophy or sarcopenia.

Disclosed is a method for preventing or treating muscular atrophy or sarcopenia, the method comprising administering a composition comprising 2′-fucosyllactose (2′-FL) as an active ingredient to a subject in need thereof. The composition administered to the subject increases the expression of genes related to mitochondrial function enhancement and mitochondrial biosynthesis, and reduces the expression of atrogin-1 and MuRF1 genes, which are markers for muscular atrophy, thereby providing effects of strengthening muscles and preventing muscular atrophy or sarcopenia.

The present invention provides compositions and methods which involve specifically antagonizing GDF8 and Activin A. In certain embodiments, compositions are provided which comprise a GDF8-specific binding protein and an Activin A-specific binding protein. For example, the invention includes compositions comprising an anti-GDF8 antibody and an anti-Activin A antibody. In other embodiments, antigen-binding molecules are provided which comprise a GDF8-specific binding domain and an Activin A-specific binding domain. For example, the invention includes bispecific antibodies that bind GDF8 and Activin A. The compositions of the present invention are useful for the treatment of diseases and conditions characterized by reduced muscle mass or strength, as well as other conditions which are treatable by antagonizing GDF8 and/or Activin A activity.

The present invention relates to a functional food composition for enhancing muscular function and exercise performance and a method for preparing same. According to the present invention, provided is a composition which enables increased generation of factors associated with myogenesis and energy metabolism and thus enhances exercise performance and muscular function. More particularly, mitochondria and muscle cell synthesis is increased and muscular atrophy is inhibited, and thus muscle exercise effects can be increased and fatigue is reduced. The composition can be applied as a health function composition to various fields such as foods.

The present invention relates to a functional food composition for enhancing muscular function and exercise performance and a method for preparing same. According to the present invention, provided is a composition which enables increased generation of factors associated with myogenesis and energy metabolism and thus enhances exercise performance and muscular function. More particularly, mitochondria and muscle cell synthesis is increased and muscular atrophy is inhibited, and thus muscle exercise effects can be increased and fatigue is reduced. The composition can be applied as a health function composition to various fields such as foods.

The present invention relates to a composition comprising Aster sphathulifolius Maxim extract for preventing, improving, or treating muscular diseases and for improving muscular functions. The Aster sphathulifolius Maxim extract according to the present invention exhibits effects of inhibiting the expression of muscle protein breakdown-related factors and increasing the expression of muscle protein synthesis-related factors, as well as alleviating the reduction of muscle tissue weight and cross-sectional area of muscle fibers, and thus can be useful for preventing, improving, or treating muscular diseases and improving muscular functions.

The present invention relates to a composition comprising Aster sphathulifolius Maxim extract for preventing, improving, or treating muscular diseases and for improving muscular functions. The Aster sphathulifolius Maxim extract according to the present invention exhibits effects of inhibiting the expression of muscle protein breakdown-related factors and increasing the expression of muscle protein synthesis-related factors, as well as alleviating the reduction of muscle tissue weight and cross-sectional area of muscle fibers, and thus can be useful for preventing, improving, or treating muscular diseases and improving muscular functions.

According to one embodiment of the present invention, provided is a composition for preventing or treating sarcopenia, containing, as an active ingredient, at least one type of unnatural amino acid selected from the group consisting of D-leucine, D-alanine and D-proline.

According to one embodiment of the present invention, provided is a composition for preventing or treating sarcopenia, containing, as an active ingredient, at least one type of unnatural amino acid selected from the group consisting of D-leucine, D-alanine and D-proline.

The object of the present invention is to provide a pharmaceutical agent which activate mitochondrial function, particularly, an inexpensive pharmaceutical agent. The problem can be solved by a mitochondrial function activator of the present invention, comprising β-alanine or glycine, or a salt thereof.