Embodiments of the present disclosure relate to the use of bupivacaine multivesicular liposomes (MVLs) as stellate ganglion block (SGB) for treating or ameliorating various diseases and conditions, including but not limited to cardiac electrical storm or cardiac arrythmia/dysrhythmia following heart surgery.

Embodiments of the present disclosure relate to the use of bupivacaine multivesicular liposomes (MVLs) as stellate ganglion block (SGB) for treating or ameliorating various diseases and conditions, including but not limited to cardiac electrical storm or cardiac arrythmia/dysrhythmia following heart surgery.

Delivery systems and compositions comprised of a biodegradable polyorthoester polymer, an aprotic solvent, and a drug are described. The solvent is selected to modulate release of drug from the composition, where, in some embodiments, the solvent is rapidly released after administration and provides a corresponding rapid rate of drug release. Alternatively, in other embodiments, the solvent is slowly released from the composition after its administration, and provides a correspondingly slow rate of drug release.

Described herein are compositions and methods for a novel drug delivery platform using affinity homing. Also disclosed herein are a drug delivery system, methods for using the novel drug delivery platform and a kit.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIi):

##STR00001##

wherein: R.sub.2=H or Me; R.sub.3=H or Me; R.sub.4=Alkyl; R.sub.5=O-Alkyl; and Alkyl=aliphatic C.sub.1-C.sub.4 alkyl.

The present disclosure further provides methods of making compounds of general formula (VIIIi), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIi), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIi) to the subject.

In some embodiments provided herein is a method of treating hip pain in a subject, the method comprising administering into the subject a pharmaceutical composition comprising: a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and b) an aqueous phase comprising bupivacaine phosphate, wherein the aqueous phase is encapsulated within the multivesicular liposome.

In some embodiments provided herein is a method of treating hip pain in a subject, the method comprising administering into the subject a pharmaceutical composition comprising: a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and b) an aqueous phase comprising bupivacaine phosphate, wherein the aqueous phase is encapsulated within the multivesicular liposome.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VI): ##STR00001##
wherein: R.sub.1 is H, Cl, F, —CF.sub.3, —OCF.sub.3, —OMe, or methyl; R.sub.8 is selected from the group consisting of: —NH.sub.2, —N(H)Alk, —N(Alk).sub.2, ##STR00002## R.sub.7 is H or alkyl; m is 3 to 6; p is 1 to 4; q is 1 to 4; p+g is 3 to 6; and each Alk is independently an aliphatic carbon group consisting of 1 to 6 carbon atoms,
and methods of making and using same.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VI): ##STR00001##
wherein: R.sub.1 is H, Cl, F, —CF.sub.3, —OCF.sub.3, —OMe, or methyl; R.sub.8 is selected from the group consisting of: —NH.sub.2, —N(H)Alk, —N(Alk).sub.2, ##STR00002## R.sub.7 is H or alkyl; m is 3 to 6; p is 1 to 4; q is 1 to 4; p+g is 3 to 6; and each Alk is independently an aliphatic carbon group consisting of 1 to 6 carbon atoms,
and methods of making and using same.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIk): ##STR00001## wherein: R.sub.2=H or Me; R.sub.3=H or Me; R.sub.4=Alkyl; R.sub.5=O-Alkyl; and Alkyl=aliphatic C.sub.1-C.sub.4 alkyl. The present disclosure further provides methods of making compounds of general formula (VIIIm), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIm), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIm) to the subject.