Compositions, devices and methods employing therapeutic concentrations of a triptan for treatment of migraine are described. Also described are methods for treating migraine by administering zolmitriptan using an adhesive dermally-applied microarray (ADAM) resulting in rapid and durable pain relief, pain freedom and reduction in most bothersome migraine-associated symptoms (MBS), or a combination thereof.

Compositions, devices and methods employing therapeutic concentrations of a triptan for treatment of migraine are described. Also described are methods for treating migraine by administering zolmitriptan using an adhesive dermally-applied microarray (ADAM) resulting in rapid and durable pain relief, pain freedom and reduction in most bothersome migraine-associated symptoms (MBS), or a combination thereof.

Pharmaceutical formulations for anti-CGRP antibodies, and methods of using the same, are provided which are useful as treatment for migraines, episodic headaches, chronic headaches, chronic cluster headaches, and episodic cluster headaches.

Pharmaceutical formulations for anti-CGRP antibodies, and methods of using the same, are provided which are useful as treatment for migraines, episodic headaches, chronic headaches, chronic cluster headaches, and episodic cluster headaches.

The present invention includes surprisingly water-soluble salts of a phenylalkylamide compound that are potent antagonists of L-type, calcium channels. Aqueous solutions including salts of the instant invention are formulated for nasal administration and provide a novel therapeutic platform for the treatment of stable angina, migraine, and cardiac arrhythmia, such as paroxysmal supraventricular tachycardia.

The present invention includes surprisingly water-soluble salts of a phenylalkylamide compound that are potent antagonists of L-type, calcium channels. Aqueous solutions including salts of the instant invention are formulated for nasal administration and provide a novel therapeutic platform for the treatment of stable angina, migraine, and cardiac arrhythmia, such as paroxysmal supraventricular tachycardia.

An auto injector apparatus includes a syringe and an auto injector. The syringe includes a barrel holding a therapeutic fluid including an anti-calcitonin gene-related peptide (anti-CGRP) antibody. The syringe also includes a stopper disposed within the barrel and the stopper moves axially within the barrel between a first position and a second position to expel at least some of the therapeutic fluid from the syringe. The auto injector includes a rod that abuts the stopper and an injection spring that drives the rod to apply a dispensing force through the rod to the stopper. The dispensing force includes a first dispensing force of between 20 N and 40 N and a second dispensing force of between 12 N and 20 N. The injection spring initially applies the first dispensing force and then applies the second dispensing force to move the stopper to the second position.

Methods for treating neurological or neuropsychiatric disorder and related symptoms by administering a CGRP antagonist and a Clostridial derivative are described.

The application describes creatine or its derivatives, compositions comprising the same, and uses thereof for topical or systemic administration to treat pain, itch, or eczema, or inflammation associated with a cosmetic or medical condition, disorder or disease in a human subject, wherein the inflammation causes the pain, itch, or eczema. In addition, the application describes clinical use of these compounds and compositions which can reduce or eliminate erythema, edema and tissue distortions associated with inflammation.

The application describes creatine or its derivatives, compositions comprising the same, and uses thereof for topical or systemic administration to treat pain, itch, or eczema, or inflammation associated with a cosmetic or medical condition, disorder or disease in a human subject, wherein the inflammation causes the pain, itch, or eczema. In addition, the application describes clinical use of these compounds and compositions which can reduce or eliminate erythema, edema and tissue distortions associated with inflammation.