Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.

Disclosed herein are pharmaceutical compositions having a mixture of at least one active agent and an ion exchange resin, such that the composition releases about 75% or more of the at least one active agent within about 1 hour as measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at about 50 rpm in about 900 ml 0.1N HCl at about 37° C. and related methods. Also disclosed herein are pharmaceutical compositions having a mixture of a drug susceptible to abuse, a non-opioid analgesic and an ion exchange resin, the composition further including at least one gelling agent and related methods.

Disclosed herein are pharmaceutical compositions having a mixture of at least one active agent and an ion exchange resin, such that the composition releases about 75% or more of the at least one active agent within about 1 hour as measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at about 50 rpm in about 900 ml 0.1N HCl at about 37° C. and related methods. Also disclosed herein are pharmaceutical compositions having a mixture of a drug susceptible to abuse, a non-opioid analgesic and an ion exchange resin, the composition further including at least one gelling agent and related methods.

The present invention relates to improved Nanobodies™ against Tumor Necrosis Factor-alpha (TNF-alpha), as well as to polypeptides comprising or essentially consisting of one or more of such Nanobodies. The invention also relates to nucleic acids encoding such Nanobodies and polypeptides; to methods for preparing such Nanobodies and polypeptides; to host cells expressing or capable of expressing such Nanobodies or polypeptides; to compositions comprising such Nanobodies, polypeptides, nucleic acids or host cells; and to uses of such Nanobodies, such polypeptides, such nucleic acids, such host cells or such compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes.

The present disclosure provides bifunctional compounds as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.

The present disclosure relates generally to a method of screening for and identifying a ligand of a Lanthionine synthetase C-like protein (LANCL) and the use of the identified ligands for the treatment of conditions, including pain. Also disclosed herein is a method of treating a condition, including pain, comprising administering to a subject in need thereof a therapeutically effective amount of an agent that binds to Lanthionine synthetase C-like protein 1 (LANCL1), wherein the agent is not a peptide derived from human growth hormone, or from a non-human homologue thereof, and wherein the agent competes for binding to LANCL1 with a cyclic peptide comprising SEQ ID NO:1 (YLRIVQCRSVEGSCGF).

The present disclosure relates generally to a method of screening for and identifying a ligand of a Lanthionine synthetase C-like protein (LANCL) and the use of the identified ligands for the treatment of conditions, including pain. Also disclosed herein is a method of treating a condition, including pain, comprising administering to a subject in need thereof a therapeutically effective amount of an agent that binds to Lanthionine synthetase C-like protein 1 (LANCL1), wherein the agent is not a peptide derived from human growth hormone, or from a non-human homologue thereof, and wherein the agent competes for binding to LANCL1 with a cyclic peptide comprising SEQ ID NO:1 (YLRIVQCRSVEGSCGF).

The invention relates to nicotinamide mononucleotide, a pharmaceutically acceptable precursor thereof, a pharmaceutically acceptable derivative thereof, or a pharmaceutically acceptable salt thereof, for the use thereof in the prevention and/or treatment of pain, in particular nociceptive pain; the invention relates as well to compositions that comprise the same.

The present invention relates to a pharmaceutical composition comprising a P2X.sub.3 and/or P2X.sub.2/3 receptor antagonist for the treatment of neuropathic pain, nociceptive pain or visceral pain, as well as interstitial cystitis and/or bladder pain syndrome.

It is a pharmaceutical composition for treating and/or preventing neuropathic pain, nociceptive pain, or visceral pain, as well as interstitial cystitis and/or bladder pain syndrome, comprising a compound represented by Formula (I):

##STR00001##

or a pharmaceutically acceptable salt thereof.

Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.