The invention relates to the use of a composition comprising at least one strain of Bacillus subtilis, for the degradation of mycotoxins.

The invention relates to the use of a composition comprising at least one strain of Bacillus subtilis, for the degradation of mycotoxins.

The invention provides probiotic bacteria and lysates thereof for use in methods of medical and cosmetic treatment. Use in the treatment of infections, including skin infections and methods involving regeneration or repair of the skin barrier are contemplated.

Liquid dressing compositions liquid for veterinary use in the treatment or prevention of infection and/or wounds are described that comprise shellac, an anti-infective metal active and a solvent. The compositions are capable of forming a barrier when topically applied to a non-human animal subject, providing an easily applied barrier for protecting lesions and other wounds from external infective agents in a veterinary setting.

The present disclosure describes systems, methods, kits, and devices for detecting and treating a fungal infection in a subject. In particular, provided herein are host gene markers that can be used for identifying and treating an Aspergillus infection. The methods, devices, kits, and systems disclosed herein are used to classify subjects based on the expression levels of the identified gene markers. In some embodiments, the Aspergillus infection comprises an infection with Aspergillus fumigatus.

Embodiments of the invention are directed to compositions containing cannabinoid, cannabidiol, cannabidiol isomer, or cannabidiol analog and combinations thereof for treating microbial infections, and methods for treating microbial infections by topically administering compositions containing cannabinoid, cannabidiol, or cannabidiol analog to the patient in need of treatment.

An antimicrobial agent comprising a selenium nanoparticle (SeNP) core and one or more superficially located antimicrobial peptide/s (AMP). The or each AMP may comprise an excess of positively charged amino acids compared to negatively charged amino acids and the AMP may comprise peptides from classes selected from polylysine, such as ε-poly-L-lysine (ε-PL), polyarginine, aurein, ovispirin, melittin, magainin, cecropin, andropin, moricin, ceratotoxin, melittin, magainin, dermaseptin, bombinin, brevinin, esculentins, buforin, cathelicidin, abaecin, apidaecin, prophenin and indolicidin. Products comprising such agents, methods of producing the agents and methods of killing or retarding growth of microorganisms exposed to the agents are also disclosed.

An antimicrobial agent comprising a selenium nanoparticle (SeNP) core and one or more superficially located antimicrobial peptide/s (AMP). The or each AMP may comprise an excess of positively charged amino acids compared to negatively charged amino acids and the AMP may comprise peptides from classes selected from polylysine, such as ε-poly-L-lysine (ε-PL), polyarginine, aurein, ovispirin, melittin, magainin, cecropin, andropin, moricin, ceratotoxin, melittin, magainin, dermaseptin, bombinin, brevinin, esculentins, buforin, cathelicidin, abaecin, apidaecin, prophenin and indolicidin. Products comprising such agents, methods of producing the agents and methods of killing or retarding growth of microorganisms exposed to the agents are also disclosed.

2-aminopyrimidine compounds and pharmaceutical compositions and uses thereof are provided. Specifically, the 2-aminopyrimidine compounds have a structure as shown in formula I. The compounds are suitable for use in the fields of anti-virus and anti-infection, as well as treatment of diseases such as autoimmune diseases and tumors.

##STR00001##

A compound represented by formula (I):

##STR00001##

or its pharmaceutically acceptable salt,
wherein
a group represented by formula:

##STR00002##

is a group represented by formula:

##STR00003##

R.sup.1 is each independently halogen, hydroxy, cyano or the like;
m is 0, 1, 2, 3 or 4;
R.sup.2 is a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl or the like;
R.sup.3a, R.sup.3b, R.sup.3c and R.sup.3d are each independently hydrogen atom, halogen or the like, with the proviso that R.sup.3a, R.sup.3b, R.sup.3c and R.sup.3d are not simultaneously hydrogen atom; ring C is represented as follows:

##STR00004##

X is CH or N;
Y is CH or N;
R.sup.4 is each independently halogen, hydroxy, cyano or the like;
p is 0 or 1;
q is 0, 1, 2, 3 or 4;
R.sup.5 is CR.sup.5C or N; R.sup.6 is CR.sup.6C or N; R.sup.7 is CR.sup.7C or N; R.sup.8 is CR.sup.8C or N; R.sup.9 is CR.sup.9C or N; with the proviso that R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are not simultaneously N;
R.sup.5C, R.sup.6C, R.sup.7C, R.sup.8C and R.sup.9C are each independently hydrogen atom or the like.