Described herein is a method for forming multi-layer drug dosage forms having at least two layers. In the method, a first formulation comprising a non-gelling matrix forming agent and having a first density is dosed into a preformed mold. A second formulation comprising a non-gelling matrix former and having a second density not equal to the first density is subsequently dosed into the preformed mold. Then, the combination of the formulations dosed into the mold is freeze dried to form the multi-layer dosage form having at least two layers. The use of a density difference between the first and second formulations ensures formation of a product with two distinct layers.

The present application relates to the treatment of nematode infections. For example, the application relates to the use of compounds of Formula (I) and/or (II) as defined herein for treatment of a nematode infection or a disease, disorder or condition arising from a nematode infection: ##STR00001##

The present invention covers new quinoline compounds of general formula (I): ##STR00001##
in which A, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

The present invention covers new quinoline compounds of general formula (I): ##STR00001##
in which A, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Provided herein are Heterocyclic compounds of formula I: ##STR00001## and pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof, wherein W, X, Y, R.sup.1, R.sup.2, and R.sup.N are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound, and methods for treating or preventing animal and human filarial worm infections and diseases.

Provided herein are Heterocyclic compounds of formula I: ##STR00001## and pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof, wherein W, X, Y, R.sup.1, R.sup.2, and R.sup.N are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound, and methods for treating or preventing animal and human filarial worm infections and diseases.

An object of the present invention is to develop and provide a novel agricultural and horticultural insecticidal and acaricidal agent due to the emergence of resistant pests against existing drugs and the like in crop production in the fields of agriculture, horticulture and the like, where damages caused by pests and the like have been still serious.

The present invention provides a benzimidazole compound represented by the general formula (1)

##STR00001##

wherein R is an alkyl group or the like, Y.sup.1, Y.sup.2, Y.sup.3, and Y.sup.4 are a hydrogen atom or the like, Q is a 5-membered heterocyclic group optionally having a substituent such as a substituted imidazole bound at a nitrogen atom and a substituted pyrazole bound at a nitrogen atom, or a salt thereof, an agricultural and horticultural insecticidal and acaricidal agent having the compound or a salt thereof as an active ingredient, and a method for using the same.

In crop production in the fields of agriculture, horticulture and the like, the damage caused by insect pests etc. is still immense, and insect pests resistant to existing insecticides have emerged. The present invention has been made in view of such circumstances, and an object of the present invention is to develop and provide a novel agricultural or horticultural insecticide. Another object of the present invention is to provide an agent capable of eliminating ectoparasites or endoparasites of animals. These objects are achieved by a condensed heterocyclic compound having a substituted cyclopropane-oxadiazole group represented by the general formula (1):

##STR00001##

(wherein R.sup.1 preferably represents an alkyl group, R.sup.2a and R.sup.2b each preferably represent a hydrogen atom, R.sup.3 preferably represents a haloalkyl group, and Q is preferably imidazo[4,5-b]pyridine) or a salt thereof, an agricultural or horticultural insecticide or an animal ectoparasite or endoparasite control agent each comprising the compound or the salt thereof as an active ingredient, and a method for using the compound or the salt thereof, the insecticide, or the control agent.

In crop production in the fields of agriculture, horticulture and the like, the damage caused by insect pests etc. is still immense, and insect pests resistant to existing insecticides have emerged. The present invention has been made in view of such circumstances, and an object of the present invention is to develop and provide a novel agricultural or horticultural insecticide. Another object of the present invention is to provide an agent capable of eliminating ectoparasites or endoparasites of animals. These objects are achieved by a condensed heterocyclic compound having a substituted cyclopropane-oxadiazole group represented by the general formula (1):

##STR00001##

(wherein R.sup.1 preferably represents an alkyl group, R.sup.2a and R.sup.2b each preferably represent a hydrogen atom, R.sup.3 preferably represents a haloalkyl group, and Q is preferably imidazo[4,5-b]pyridine) or a salt thereof, an agricultural or horticultural insecticide or an animal ectoparasite or endoparasite control agent each comprising the compound or the salt thereof as an active ingredient, and a method for using the compound or the salt thereof, the insecticide, or the control agent.

Biocide and biopesticide compositions are provided. The compositions include mixtures of essential oils and carriers, the combined effect of which provides repelling and/or killing effects against arthropod pests and internal parasites. Methods of controlling and treating for arthropod pests and internal parasites using the disclosed compositions are also provided.