This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

The present invention relates to a liquid spreading composition with ectoparasiticidal activity. The invention also relates to a method and use of such a liquid spreading composition for combating ectoparasites in human and veterinary medicine, as well as in agricultural, horticultural and/or garden environments. The composition comprises at least one emollient ester and isohexadecane, wherein the weight ratio of said at least one emollient ester to isohexadecane is within 1:9 to 7:3. The invention improves the spreading properties of a composition enabling it for an efficient delivery of an active substance or substances over the surface of the host on which it is applied. The spreading composition may also be used alone for an efficient ectoparasiticidal treatment in human and veterinary medicine, as well as for combating ectoparasites in agricultural, horticultural and/or garden environments. With at least one additional agent the spreading composition may also be used in cosmetic, as well as for pest control, including insect and rodent control.

The invention relates to a formed body for the administration to animals and to a process for the production of the formed body for the administration to animals. The formed body serves in particular for the oral administration of pharmaceutically active substances to animals. The formed body for the administration to animals comprises one or more pharmaceutically active substance, one or more flavouring agents, one or more binding agents, one or more gel-forming agents, one or more fillers, water and glycerol.

The invention relates to a formed body for the administration to animals and to a process for the production of the formed body for the administration to animals. The formed body serves in particular for the oral administration of pharmaceutically active substances to animals. The formed body for the administration to animals comprises one or more pharmaceutically active substance, one or more flavouring agents, one or more binding agents, one or more gel-forming agents, one or more fillers, water and glycerol.

Provided herein are Heterocyclic compounds of formula I:

##STR00001## and pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof, wherein W, X, Y, R.sup.1, R.sup.2, and R.sup.N are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound, and methods for treating or preventing animal and human filarial worm infections and diseases.

Provided herein are Heterocyclic compounds of formula I:

##STR00001## and pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof, wherein W, X, Y, R.sup.1, R.sup.2, and R.sup.N are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound, and methods for treating or preventing animal and human filarial worm infections and diseases.

The present invention relates to new anthelmintic compounds. These compounds can for example be used in the treatment of the kind of worm disease caused by helminths such as Dirofilaria, in particular Dirofilaria immitis.

The present invention relates to new anthelmintic compounds. These compounds can for example be used in the treatment of the kind of worm disease caused by helminths such as Dirofilaria, in particular Dirofilaria immitis.

The invention provides pharmaceutical compositions for the treatment of neoplastic diseases, fluke infestations and Lyme disease, comprising compounds capable of providing dihydroartemesinin and a medium chain triglyceride formulated for transmucosal sublingual, buccal or nasal delivery, especially by a spray. Also provided are delivery devices containing the compositions.

Provided are compounds of the formula (I)

##STR00001##

which are suitable for controlling animal pests including arthropods and in particular insects and acarids and in which the structural elements have the meanings given in the description.