Disclosed are compounds of formula (I) which possess pesticidal, especially nematicidal properties wherein in the structural elements have the meaning as indicated in the description. ##STR00001##

The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.

Provided are liposomes including a lipid membrane enclosing an intraliposomal compartment. The liposomes may encapsulate an iron complex, including an iron moiety and a macromolecule, in the intraliposomal compartment. The liposomes may additionally have a targeting moiety associated with the liposomal membranes. The targeting moiety may be exposed at the liposome's outer surface. The liposomes exhibit an immunomodulatory effect or anti-cancer effect depending on the molar ratio between the lipids forming the lipid membrane and the iron complex. As such, the liposomes can be used to treat types of inflammation, particularly inflammations that are not associated or caused by infection or be used to treat cancer. Further provided are compositions including the disclosed liposomes, methods of using and kits including the liposomes.

This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This invention also provides new isoxazoline active agents with long-lasting efficacy against ectoparasites. The invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the novel isoxazoline compounds and long-acting injectable compositions of the invention to the animal in need thereof.

A method of controlling pest with a pesticidal composition comprising synergistically effective amounts of at least one anthranilamide compound represented by the formula (I) or its salt and other pesticide: ##STR00001##
wherein each of R.sup.1a and R.sup.1b which are independent of each other, is halogen; each of R.sup.2 and R.sup.3 is halogen, alkyl, haloalkyl, alkoxy, haloalkoxy or cyano; A is alkyl substituted by Y; Y is C.sub.3-4 cycloalkyl which may be substituted by at least one substituent selected from the group consisting of halogen, alkyl and haloalkyl; n is 0 or 1; and q is an integer of from 0 to 4; provided that R.sup.1a and R.sup.1b are not simultaneously chlorine nor bromine.

A compound represented by Formula (I), or a salt thereof:

##STR00001##

wherein, R.sup.1 represents an unsubstituted or substituted C1-6 alkylthio group, or the like; A.sup.1 represents a nitrogen atom or CH; A.sup.2 represents a nitrogen atom or CR.sup.2; R.sup.2 and R.sup.3 each independently represents a hydrogen atom, an unsubstituted or substituted C6-10 aryl group, an unsubstituted or substituted 3- to 6-membered heterocyclyl group, or the like; B.sup.1 and B.sup.2 each independently represents a nitrogen atom or CR.sup.5, with the proviso that B.sup.1 and B.sup.2 do not represent CR.sup.5 at the same time, wherein R.sup.5 represents a hydrogen atom, an unsubstituted or substituted C1-6 alkyl group, or the like; R.sup.4 represents an unsubstituted or substituted C1-6 alkyl group, or the like, and R.sup.4 binds to any one of nitrogen atoms forming an imidazole ring or a triazole ring; and Ar represents an unsubstituted or substituted C6-10 aryl group or the like.

A semiochemical composition comprising a sea lice copepodits attachment inhibiting semiochemical comprising a synthesized palmitoleic acid, salts thereof, derivatives thereof, isomers thereof and/or structural analogs thereof and/or mixtures thereof and an acceptable vehicle is described. Also described are methods to treat sea lice comprising administering to fish in need of such treatment a semiochemical composition comprising a sea lice attachment inhibiting semiochemical comprising a synthesized palmitoleic acid, salts thereof, derivatives thereof, isomers thereof and/or structural analogs thereof and/or mixtures thereof and an acceptable vehicle.

A compound represented by a formula (I) or a salt thereof: ##STR00001## wherein A.sup.1 represents CR.sup.1 or a nitrogen atom; A.sup.2 represents CR.sup.2 or a nitrogen atom; A.sup.3 represents CR.sup.3 or a nitrogen atom, provided that two or more of A.sup.1 to A.sup.3 do not represent nitrogen atoms at the same time; R.sup.1, R.sup.2 and R.sup.3 each independently represent a hydrogen atom or the like; B.sup.1 represents CH or a nitrogen atom; R.sup.4 represents a substituted or unsubstituted C.sub.1-6 alkyl group or the like; R.sup.5 represents a substituted or unsubstituted C.sub.1-6 alkylthio group or the like; and R.sup.6 represents a substituted or unsubstituted C.sub.1-6 alkyl group or the like.

Disclosed herein are methods for treating skin conditions associated with skin parasites, including mites, by administering a therapeutically effective amount of 3,5-dihydroxy-4-isopropyl-trans-stilbene (DHIS).

The invention provides the use of a compound for the manufacture of a medicament for the treatment of pain, wherein the compound is a compound of the formula (VI): ##STR00001##
or a salt, solvate, tautomer or N-oxide thereof;
wherein the bicyclic group: ##STR00002##
is selected from the structures C1, C5 and C6: ##STR00003##
wherein n, R.sup.1, R.sup.2a, R.sup.3, R.sup.4a, R.sup.8 and R.sup.10 are as defined in the claims. The invention also provides the use of a compound of the formula (VI) for the manufacture of a medicament for the prophylaxis or treatment of a fungal, protozoal, viral or parasitic disease state or condition (other than a disease state or condition due to Plasmodium falciparum) or for use in the prophylaxis or treatment of Ewing's sarcoma, atherosclerosis or lupus erythematosus.