Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.

Provided herein are pharmaceutical compositions and methods treating Demodex or a disorder thereof around the eye by application of a metered dose of a semi-solid product from a product tube.

Provided herein are pharmaceutical compositions and methods treating Demodex or a disorder thereof around the eye by application of a metered dose of a semi-solid product from a product tube.

Provided herein are methods of treating a clinical symptom and/or transmission risk associated with a pathogen in an individual, including related pharmaceutical formulations, the method comprising the steps of: administering to the individual having the clinical symptom or at transmission risk of the pathogen, an active agent in a dosage effective to inactivate Demodex mites in or on the individual; thereby resulting in amelioration or cessation of the clinical symptoms and/or transmission risk associated with the pathogen.

Provided herein are methods of treating a clinical symptom and/or transmission risk associated with a pathogen in an individual, including related pharmaceutical formulations, the method comprising the steps of: administering to the individual having the clinical symptom or at transmission risk of the pathogen, an active agent in a dosage effective to inactivate Demodex mites in or on the individual; thereby resulting in amelioration or cessation of the clinical symptoms and/or transmission risk associated with the pathogen.

In various aspects and embodiments the invention provides methods and compositions for generating tick immunity.

In various aspects and embodiments the invention provides methods and compositions for generating tick immunity.

This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

The present invention relates to a liquid spreading composition with ectoparasiticidal activity. The invention also relates to a method and use of such a liquid spreading composition for combating ectoparasites in human and veterinary medicine, as well as in agricultural, horticultural and/or garden environments. The composition comprises at least one emollient ester and isohexadecane, wherein the weight ratio of said at least one emollient ester to isohexadecane is within 1:9 to 7:3. The invention improves the spreading properties of a composition enabling it for an efficient delivery of an active substance or substances over the surface of the host on which it is applied. The spreading composition may also be used alone for an efficient ectoparasiticidal treatment in human and veterinary medicine, as well as for combating ectoparasites in agricultural, horticultural and/or garden environments. With at least one additional agent the spreading composition may also be used in cosmetic, as well as for pest control, including insect and rodent control.

A compound of Formula (I) where Q represents a group represented by Q2, . represents a site of binding with the rest of molecules, T1 represents a group represented by T1-1, Z represents an oxygen atom, A.sup.2 represents CR.sup.4a, B.sup.1 represents CR.sup.38a, B.sup.2 represents CR.sup.1, B.sup.3 represents a nitrogen atom, G.sup.1 represents a nitrogen atom or CR.sup.3a, G.sup.2 represents a nitrogen atom or CR.sup.3b, G.sup.3 represents a nitrogen atom or CR.sup.3c, G.sup.4 represents a nitrogen atom or CR.sup.3d, R.sup.1 represents a C1-C6 chain hydrocarbon group that is substituted with one or more substituents selected from the group consisting of a cyano group and a halogen atom, R.sup.2 represents a C1-C6 alkyl group, and R.sup.3a, R.sup.3b, R.sup.3c, R.sup.3d, R.sup.4a, and R.sup.6 are the same or different and represent a C1-C6 chain hydrocarbon group, R.sup.38a represents a C1-C3 chain hydrocarbon group or the like, and n represents 0, 1, or 2.