The present application relates to novel bicyclic compounds, to their use for controlling animal pests and to processes and intermediates for their preparation.

The present invention concerns materials and methods for treating an ocular Demodex mite infestation of an eye of a human or animal subject, or for treating a condition of the eye or skin associated with ocular Demodex mite infestation, the method comprising topically administering a composition comprising one or more spinosyn compounds to the ocular surface (conjunctiva and/or cornea) or other anatomical structure of the eye, or to an area adjacent the eye.

A method for inhibiting hatching of an ectoparasite egg, the method comprising exposing the ectoparasite egg to at least one metal chelating agent and/or metalloprotease inhibitor, wherein the metal chelating agent is a compound comprising at least two heteroatoms able to simultaneously coordinate with a metal ion, at least one of the two heteroatoms being selected from nitrogen, sulfur, oxygen and phosphorus, wherein the compound comprises at least one carbocyclic ring substituted with at least one heteroatom and/or with a substituent containing at least one heteroatom, or the compound comprises at least one heterocyclic ring containing at least one heteroatom, wherein said heterocyclic ring is optionally substituted with at least one heteroatom and/or with a substituent containing at least one heteroatom is provided. Methods of treating ectoparasite infestations and compositions for use in such methods are also provided.

The present invention relates to methods of treating demodicosis by administering an isoxazoline compound of formula (I).

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Disclosed are an external preparation of imidacloprid, a preparation method and use thereof, which relates to the technical field of veterinary drugs. The present disclosure uses alcohol solvent as the dispersion medium of imidacloprid technical, which can ensure the stability of imidacloprid technical; The present disclosure uses one or more of dibutyl hydroxytoluene, hydroxymethyl, propyl hydroxybenzoate and butylated hydroxyanisole as the antioxidant, which can effectively prevent the oxidation of imidacloprid technical and prolong the preservation time of external preparations of imidacloprid; The present disclosure uses one or more of propylene carbonate, povidone and copovidone as the stabilizer, which can reduce the volatility of the solvent and maintain the stability of the dispersion system. At the same time, the adjuvants used in the present disclosure have the advantages of safety, no skin irritation, low cost, and are suitable for market promotion and application.

Disclosed are an external preparation of imidacloprid, a preparation method and use thereof, which relates to the technical field of veterinary drugs. The present disclosure uses alcohol solvent as the dispersion medium of imidacloprid technical, which can ensure the stability of imidacloprid technical; The present disclosure uses one or more of dibutyl hydroxytoluene, hydroxymethyl, propyl hydroxybenzoate and butylated hydroxyanisole as the antioxidant, which can effectively prevent the oxidation of imidacloprid technical and prolong the preservation time of external preparations of imidacloprid; The present disclosure uses one or more of propylene carbonate, povidone and copovidone as the stabilizer, which can reduce the volatility of the solvent and maintain the stability of the dispersion system. At the same time, the adjuvants used in the present disclosure have the advantages of safety, no skin irritation, low cost, and are suitable for market promotion and application.

An application of a series of compounds in controlling or killing mites. It has been found by comparison that the compounds, when compared with a control group, can reduce the survival time of mites; in particular, taraxerol, diosmetin, and taraxasteryl acetate can significantly shorten the survival time of mites, and can be used for miticide and mite control products (such as drugs, cosmetic products, daily products and so on).

The invention provides for spot-on formulations comprising fipronil in a high concentration for the treatment or prophylaxis of parasites of mammals and birds, and in particular, cats, dogs, horses, chickens, sheep and cattle with the aim of ridding these animals of all the parasites commonly encountered by birds and mammals. The invention also provides for effective and lasting destruction of ectoparasites, such as fleas, ticks, itch mites and lice, and of endoparasites, nematodes, such as filariae, and roundworms of the digestive tract of animals and humans.

Pharmaceutically acceptable single parasiticidal agent compositions of imidacloprid for oral delivery to mammals to systemically control targeted blood-sucking or blood-consuming parasites, such as fleas, ticks and certain species of helminthes and scabies.

The present application relates to novel bicyclic compounds, to compositions comprising these compounds, to their use for controlling animal pests and to processes and intermediates for their preparation.