The present invention is directed to a method of treating a fungal infection comprising administering topically, to a subject in need thereof, an anti-fungal effective amount of roflumilast. Preferably, topically administered roflumilast is used to treat fungal infections, fungal growth of and/or hypersensitivity to the fungi Malassezia spp. Patients may also be suffering from seborrheic dermatitis, dandruff, dupilumab facial redness, Tinea versicolor, Pityriasis versicolor, Tinea circinata, Tinea pedis, Tinea unguium, Tinea manus, Tinea cruris, Tinea corporis, Tinea faciei, Tinea capitis, and/or Tinea incognito. Topically administered roflumilast is a quick and effective antifungal agent and presents a viable alternative to current antifungal treatments.

A method for inhibiting hair growth in mammals using compositions containing FP receptor antagonists (e.g., prostaglandin F analogs that are block activation of the FP receptor). The compositions can be applied topically to the skin and/or hair. The compositions can arrest hirsutism or hypertrichosis, reverse hirsutism and hypertrichosis, and further prevent hair growth. These compositions can also be used to protect hair from chemical or radiation-induced alopecia or hair loss. These compositions can also be used to inhibit pigmentation of the hair or skin.

A fragrance-containing microparticle of water-insoluble polymeric material, the polymer having a glass transition temperature of from 0° C. to 50° C. and a zeta potential lying within the ranges −40 mV to −5 mV and +5 mV to +45 mV. The microparticles have enhanced substantivity to hair, resulting in a longer-lasting fragrance.

A fragrance-containing microparticle of water-insoluble polymeric material, the polymer having a glass transition temperature of from 0° C. to 50° C. and a zeta potential lying within the ranges −40 mV to −5 mV and +5 mV to +45 mV. The microparticles have enhanced substantivity to hair, resulting in a longer-lasting fragrance.

The inventive subject is directed towards ready-to-use topical cosmetic formulations that include at least one defensin present in sub-antimicrobially effective concentrations. Surprisingly, even at such low concentrations, defensins recruit LGR6+ stem cells from hair follicles to the interfollicular space. Including defensins in the inventive topical cosmetic formulations may reduce one or more of wrinkle depth, wrinkle length, wrinkle width, pore size, irregularity in texture of a skin surface, oiliness, brown spots, and red spots in non-injured skin, thus reducing apparent age.

The inventive subject is directed towards ready-to-use topical cosmetic formulations that include at least one defensin present in sub-antimicrobially effective concentrations. Surprisingly, even at such low concentrations, defensins recruit LGR6+ stem cells from hair follicles to the interfollicular space. Including defensins in the inventive topical cosmetic formulations may reduce one or more of wrinkle depth, wrinkle length, wrinkle width, pore size, irregularity in texture of a skin surface, oiliness, brown spots, and red spots in non-injured skin, thus reducing apparent age.

The invention relates to stable, mild and moisturizing lamellar liquid cleansing compositions which possess a lotion-like appearance conveying signals of enhanced moisturization. However, these liquids often are either unstable or cause poor lather production and other sensory deficits The use of a specific ratio of total acyl isethionates to acyl glutamates or other divalent anionic surfactant in a structured liquid product improve stability and lather production, mildness and acceptable odor.

The invention relates to stable, mild and moisturizing lamellar liquid cleansing compositions which possess a lotion-like appearance conveying signals of enhanced moisturization. However, these liquids often are either unstable or cause poor lather production and other sensory deficits The use of a specific ratio of total acyl isethionates to acyl glutamates or other divalent anionic surfactant in a structured liquid product improve stability and lather production, mildness and acceptable odor.

Described herein are hybrid microcapsules with a hydrophobic material-based core, such as a perfume, and a polymeric shell including chitosan particles. Processes for preparing such microcapsules are also described, as are perfuming compositions and consumer products including the capsules, in particular, perfumed consumer products in the form of home care or personal care products.

Disclosed herein are hygiene product pods and a method of using the hygiene product pods. A hygiene product pod can include a water-soluble envelope and a hygiene product sealed in the water-soluble envelope. A hygiene product as described herein can comprise a non-aqueous carrier. A non-aqueous carrier as described herein can comprise a polyol solvent and a polyglyceryl fatty acid ester (PGEs) chassis.