Compositions and methods are disclosed herein for inducing (up-regulating) the expression of sulfotransferases in the hair follicles, e.g., the scalp. Increasing sulfotransferase is beneficial for metabolizing pro-drugs that require sulfonation to be activated, e.g., minoxidil sulfate is the active metabolite of minoxidil. A method for combining the compositions described herein with topical minoxidil to enhance minoxidil treatment for androgenetic alopecia is described. Additional methods and compositions include the use of retinoid X receptor agonists, retinoic acid receptor agonists, and nuclear receptor agonists in an RXRNR heterodimer. Additional methods and compositions include the use of a topical solution containing an alkalinizing agent or an alkalinizing agent used with a penetration enhancer for up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells. In addition, compositions and methods for increasing or decreasing the growth rate of hair follicles is disclosed by altering the intracellular pH.

The described invention provides cosmetic formulation stabilizing systems comprising an arginine component and organic acid component, for preserving cosmetic formulations, stable cosmetic and dermatologic formulations comprising the cosmetic formulation stabilizing system, methods for manufacturing the same, and the use of such compositions for skin care.

The described invention provides cosmetic formulation stabilizing systems comprising an arginine component and organic acid component, for preserving cosmetic formulations, stable cosmetic and dermatologic formulations comprising the cosmetic formulation stabilizing system, methods for manufacturing the same, and the use of such compositions for skin care.

A heat amplified skin treatment method and system including applying a predetermined one of a plurality of serum solutions to the skin. A wax composition is pre-heated into a liquid state and applied to the skin in covering relation to the applied, predetermined serum solution and in heat transferring relation to the area of the skin. A mask forms, via a cooling of the wax composition, and is disposed in encapsulating relation to the predetermined serum solution, on the skin. After expiration of a predetermined time period, the mask is removed. The results of the skin treatment are further enhanced by the application of selected serum-locking, cleanser and toner compositions at different stages during the skin treatment.

A heat amplified skin treatment method and system including applying a predetermined one of a plurality of serum solutions to the skin. A wax composition is pre-heated into a liquid state and applied to the skin in covering relation to the applied, predetermined serum solution and in heat transferring relation to the area of the skin. A mask forms, via a cooling of the wax composition, and is disposed in encapsulating relation to the predetermined serum solution, on the skin. After expiration of a predetermined time period, the mask is removed. The results of the skin treatment are further enhanced by the application of selected serum-locking, cleanser and toner compositions at different stages during the skin treatment.

A dietary composition including saw palmetto and coconut oil in a proportion whereby the daily dose provides a controlled amount of fatty acids, having a minimum of 37.5 mg lauric acid and 16.44 mg myristic acid.

Compositions and methods are disclosed herein for inducing (up-regulating) the expression of sulfotransferases in the hair follicles, e.g., the scalp. Increasing sulfotransferase is beneficial for metabolizing pro-drugs that require sulfonation to be activated, e.g., minoxidil sulfate is the active metabolite of minoxidil. A method for combining the compositions described herein with topical minoxidil to enhance minoxidil treatment for androgenetic alopecia is described. Additional methods and compositions include the use of retinoid X receptor agonists, retinoic acid receptor agonists, and nuclear receptor agonists in an RXR-NR heterodimer. Additional methods and compositions include the use of a topical solution containing an alkalinizing agent or an alkalinizing agent used with a penetration enhancer for up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells. In addition, compositions and methods for increasing or decreasing the growth rate of hair follicles is disclosed by altering the intracellular pH.

Compositions and methods are disclosed herein for inducing (up-regulating) the expression of sulfotransferases in the hair follicles, e.g., the scalp. Increasing sulfotransferase is beneficial for metabolizing pro-drugs that require sulfonation to be activated, e.g., minoxidil sulfate is the active metabolite of minoxidil. A method for combining the compositions described herein with topical minoxidil to enhance minoxidil treatment for androgenetic alopecia is described. Additional methods and compositions include the use of retinoid X receptor agonists, retinoic acid receptor agonists, and nuclear receptor agonists in an RXR-NR heterodimer. Additional methods and compositions include the use of a topical solution containing an alkalinizing agent or an alkalinizing agent used with a penetration enhancer for up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells. In addition, compositions and methods for increasing or decreasing the growth rate of hair follicles is disclosed by altering the intracellular pH.

Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I

##STR00001##

wherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration, A, B, Z, X, R.sub.1 and R.sub.2 are as defined in the specification. Such compositions are used in treating the skin or scalp of a human or non-human animal. Bimatoprost is preferred for this treatment.

Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I

##STR00001##

wherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration, A, B, Z, X, R.sub.1 and R.sub.2 are as defined in the specification. Such compositions are used in treating the skin or scalp of a human or non-human animal. Bimatoprost is preferred for this treatment.