Multi-component pharmaceutical compositions perform various functions and confer various benefits, but often with reduced benefits resulting from interference and cancellation effects between components. To avoid this problem multi-component pharmaceutical compositions can include three separate compositions, each differing by at least one component, or in which all components differ. Doses from each composition are taken over a given period of time, such as a day. One dose from a first composition is taken in the morning, a dose from a second composition is taken at mid-day, and a dose from a third composition is taken at night, for example. Methods of preventing, treating, and mitigating various diseases and disorders, including Alzheimer's disease and related disorders, autism spectrum disorders, cancer, and thrombosis also appear.

The combination of polyols with certain active ingredients has been found to mitigate the potential irritating nature of some active ingredients (e.g., hydroxy acids, etc.). When applied to lips, this combination may provide for therapeutic and/or cosmetic benefits including smoother lips, increased moisturization, reduced water loss and combinations thereof. However, formulating stable emulsions with certain active ingredients has proved problematic. The present application also provides new stabilization mechanisms for the emulsions involving alteration of the extensional viscosity of the internal phase.

The present invention relates to functional food supplement formulations comprising a) a phase composed of a mixture of nanosome spheres of biotechnological origin added to low molecular weight hyaluronic acid in a concentration of 5 to 10% by weight, b) a phase of plant actives in a concentration of 10 to 30% by weight, in each case based on the total weight of the formulation, and can optionally also include other active principles, auxiliaries and additives, and the use of this formulation in the form of a functional lipstick.

A lip balm applicator product comprises upper and lower portions that are connectable together to define the applicator product being of a substantially spherical shape. A support platform is located in the lower portion and accommodates a quantity of lip balm having an arcuate surface. A lip balm comprises a composition of waxes and oils in solid form and formed to have an arcuate surface. The composition is formed to have the arcuate surface using a hot pour process. A method of manufacturing a lip balm comprises providing a receptacle having a concave arcuate surface. A lip balm material in a heated, liquefied phase is poured into the receptacle. Once poured, the heated, liquefied phase is allowed to solidify such that a surface of the solidified lip balm material has an arcuate configuration that corresponds to the concave arcuate surface of the receptacle.

Described herein are lipstick compositions that are substantive, aesthetically appealing, do not pool on the lips, are easy to spread, and moisturize the lips. The compositions comprise cosmetic ingredients such as conditioning agents, moisturizing agents, antioxidants, structuring agents, emulsifiers, silicone containing compounds, essential oils, thickening agents, preservatives, and colorants, for example.

Disclosed herein are lip scrub compositions comprising an exfoliating agent that is not a granulated sugar. The lip scrub compositions disclosed herein may further comprise one or more ingredients selected from an emollient, flavoring agent, colorant, abrasive, drug agent, thickening agent, and vitamin.

The invention relates to a preparation containing: (i) a composition containing (a) one, two or a plurality of compounds selected from the group consisting of (a1) alcohol monoterpenes of formula (I) in which R1 is H or methyl, R2 is H or C.sub.2-alkenyl, und R3 is a linear or branched, saturated or unsaturated hydrocarbon radical with 4 to 10 carbon atoms, and the enantiomers, diastereomers, racemates, solvates and physiologically compatible salts thereof, and/or (a2) bicyclic epoxy-monoterpenes, (b) at least two lactones of formula (II) in which R4 is H or methyl, R5 is a linear or branched, saturated or unsaturated hydrocarbon radical with 2 to 10 hydrocarbon atoms and n is the number 1 or 2, and the enantiomers, diastereomers and racemates thereof, (c) one, two or a plurality of solvents selected from the group consisting of ethanol, water, dipropylene glycol (DPG), diethyl phtalate (DEP), propylene glycol (PG), isopropyl myristate (IPM), isopropyl palmitate (IPP), triethyl citrate (TEC), triacetin (TRI), 1,2-Propanediol, 1,3-Propanediol, Propanethiol, Pentanediol, Hexanediol, Octanediol, Decanediol (SymClariol®), Dodecanol, 4-hydroxy-acetophenone (SymSave® H), glycerine, butylene glycol, pentylene glycol, hexylene glycol, decylene glycol, propylene carbonate, butylene carbonate, glycerine carbonate, 2-5 benzyl heptanol, lauryl alcohol, trimethyl-hydroxypentyl-isobutyrate, glyceryl-caprylate, ethylhexyl glycerine, benzyl benzoate (BB), and optionally (d) other flavouring agents or aromatic substances selected from the group consisting of 3-phenylbutanal (Trifernal), acetyl methyl carbinol, anethole, anisyl acetate, dihydroeugenol, linalyl formate, 2-methyldecanal, 2-benzyl-2-methylbut-3-ene nitrile (Ci-Trowanil® B), 3-hexenyl acetate, styrallyl acetate, belanis, citronellal, cinnamyl acetate, rhubafuran, beta-ions, anther, prenyl acetate, 2-phenyl propanal, 4-(4-hydroxyphenyl)butan-2-one (Frambinon®), ethyl phenoxyacetate, isoralderine, gamma-terpinene, limonene, neocyclocitral, methyl lavender ketone, styrallyl propionate, phenyl ethyl propionate, limonenal, 4-isopentylcyclohexanol (Symrose®), 4-methyl-2-phenyl-3,6-dihydro-2H-pyran/4-methylene-2-phenyl-tetrahydropyrane (Rosyrane super), hydrocitronitril, phenoxanol, isoamyl phenylacetate, damascone, silvial, nectaryl, ambroxide, acetyl pyrazine, trimethyl pyrazine, isoamyl acetate, para-cresyl methyl ether, filbertone, cyclohexyl acetate, heliotropin, acetophenone, anisaldehyde, para-methyl acetophenone, veratraldehyde, methyl anisate and vertoprenal; (ii) aldehydes of formula (III) in which R6 is a saturated or non-saturated, linear hydrocarbon radical; and/or (iii) free fatty acids of formula (

The present invention generally relates to the field of hyaluronic acid (HA) dermal fillers, and more specifically to methods for preparing crosslinked HA-based compositions in the form of a gel comprising high-temperature dialysis and/or crosslinking in the presence of phosphate and an alkaline metal halide salt. The present invention further relates to crosslinked HA-based gel compositions prepared by said methods and their use as dermal fillers in aesthetic applications such as wrinkle treatments.

Provided are lip-based compositions such as lipsticks, lip balms, and lip glosses that have favorable transparency, haze, temperature stability, hardness, taste, payoff, moisturizing effect, feel, and/or resistance to droop and/or shear. In certain embodiments, the lip-based compositions are for use with a container that exposes a substantial percentage of the surface area of the lip-based composition. Also provided are processes for production of such lip-based compositions.

There are provided odorless shea based esters as an ingredient composition comprising: a) 81-97 wt % of at least one short chain alcohol alkyl ester, at least partially from a natural source, b) 3-19 wt % of triterpene esters where at least one is a cinnamic triterpene ester, and c) 1100 ppm or less of at least one short chain alcohol cinnamic ester. There is further provided a method of manufacturing the composition comprising a deodorization step. An advantage is that an odourless or an almost odourless composition can be provided.