The invention relates to a lipid extract of the seeds of passion fruit, Passiflora incarnata and/or Passiflora edulis, preferably P. edulis, characterised in that said lipid extract is an oil of passion fruit seeds concentrated in its unsaponifiable fraction, containing between 3 wt. % and 100 wt. % of unsaponifiable matter in relation to the total weight of the extract. The invention also relates to a method for preparing such an extract and to a composition comprising said extract, especially for the use thereof in a dermatological or pharmaceutical composition or as a food.

Described herein are compounds, compositions and methods for the treatment of a subject having cancer, skin conditions, blood flow and/or growth failure. In one aspect of the present invention, there is provided compositions and methods for treating a subject having cancer, skin conditions, blood flow and/or growth failure, comprising fat derived from a camel. There are also described sunscreen and photoprotective compounds, compositions and methods, comprising fat derived from a camel.

The c-family cytokines, Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-7 (IL-7), Interleukin-9 (IL-9), Interleukin-15 (IL-15), and Interleukin-21 (IL-21), are associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases, diabetes mellitus, skin diseases, degenerative neuronal diseases and graft-versus-host disease (GvHD). Thus, inhibitors of c-cytokine activity are valuable therapeutic and cosmetic agents as well as research tools. Peptide and/or peptide derivative antagonists based on the consensus c-subunit binding site to inhibit c-cytokine activity are described. Also described are peptide and/or peptide derivative antagonists exhibiting Simul-Block activity, and inhibiting the activity of multiple c-cytokine family members.

This disclosure relates to new compositions and methods for treating skin conditions as a result of sun damage. In one embodiment this disclosure pertains to new compositions for treating or preventing sunburns, skin damage, and/or harm from radiation, such as UV radiation.

The present invention pertains to methods of extracting cardiac glycosides from cardiac glycoside containing plant material, such as Nerium oleander, through use of aloe. It further provides for compositions resulting from such extractions, pharmaceutical compositions, cosmetic compositions, and methods of treating skin conditions.

A method for decreasing formation of one or more chemiexcitation-induced dark cyclobutane pyrimidine dimers (dCPDs) in a cell or DNA molecule in a subject, who has been exposed to UV radiation, is provided. The method comprises administering to the subject an effective amount of a dCPD quencher within 8 hours after the exposure. The dCPD quencher is selected from the group consisting of ellagic acid, Porphyra Umbilicalis Extract (including Porphyra Umbilicalis Extract (and) Sodium Lactate (and) Lecithin), mycosporine-like amino acids (MAAs) and synthetic analogues thereof, Scutellaria Baicalensis Root Extract, Chrysanthemum Morifolium Leaf Extract, ferulic acid, fused-ring cyanoacrylates, curcumin, epigallocatechin gallate, Scutellaria Baicalensis Root Extract (and) Acacia Catechu Wood Extract, sorbic acid, Polygonum Cuspidatum Root Extract, Acacia Catechu Extract, dipicolinic acid, squalene, Lonicera Japonica (Honeysuckle) Flower Extract, beta-carotene and combinations thereof. The dCPD quencher may be administered to the subject in the absence of UV radiation.

Mixtures comprising a selected cooling active ingredient (E)-3-benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide and at least one other substance which acts as a solvent for (E)-3-benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide, wherein the substance is selected form the group consisting of benzyl benzoate, diethyl succinate, triethyl citrate, triacetin, ethanol, peppermint oil, anethol, optamint, propylene glycol, further cooling active ingredients or mixtures thereof.

The ?c-family cytokines, Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-7 (IL-7), Interleukin-9 (IL-9), Interleukin-15 (IL-15), and Interleukin-21 (IL-21), are associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases, diabetes mellitus, skin diseases, degenerative neuronal diseases and graft-versus-host disease (GvHD). Thus, inhibitors of ?c-cytokine activity are valuable therapeutic and cosmetic agents as well as research tools. Peptide and/or peptide derivative antagonists based on the consensus ?c-subunit binding site to inhibit ?c-cytokine activity are described. Also described are peptide and/or peptide derivative antagonists exhibiting Simul-Block activity, and inhibiting the activity of multiple ?c-cytokine family members.

Provided are a cosmetic composition for preventing or ameliorating a ultraviolet-induced skin damage including mitochondria-targeted vitamin E as an active ingredient, as well as a method for protecting skin from ultraviolet-induced skin damage or for ameliorating an ultraviolet-induced skin damage using the same compound.

A subject matter of the present invention is the cosmetic use of at least one compound of formula (I): in which: (II) denotes a divalent radical chosen from a carbon-carbon single bond *CH.sub.2CH.sub.2* or double bond *CHCH*, of Z or E configuration or their mixtures, b=0 or 1, c=0 or 1, d=0, 1 or 2, and R and R independently denote a hydrogen atom, a linear C.sub.1-C.sub.6 alkyl radical or a branched C.sub.3-C.sub.6 alkyl radical, to treat and/or prevent signs of aging and/or of photoaging of keratinous substances, preferably of the skin, and/or to depigment, lighten and/or whiten keratinous substances, preferably the skin. The present invention also relates to novel compounds and to a corresponding cosmetic method.

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