The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.

Red blotches on the skin such as those associated with environmental stresses, or red blotches associated with a skin disorder, for example those occurring during rosacea, are treated/reduced by administering to individuals afflicted therewith, thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.

A process of providing a topical solution which includes a high level of resveratrol by using a low temperature mixing process. The low temperature mixing process uses key ingredients that mix at low temperatures eliminating the risk of heat oxidation that creates Radical Oxygen Species that bind with resveratrol.

An inverse emulsion copolymer composition comprises (A) an aqueous phase comprising a cross-linked hydrophilic polyelectrolyte copolymer (A′) obtained by the free radical copolymerisation of: (i) at least one anionic ethylenically unsaturated monomer bearing a negatively charged group and one polymerisable C═C double bond, or at least one cationic ethylenically unsaturated monomer bearing a positively charged group and one polymerisable C═C double bond, and (ii) at least one non-ionic ethylenically unsaturated cross-linking monomer bearing at least two polymerisable C═C double bonds, and (iii) optionally, one or more hydrophilic non-ionic ethylenically unsaturated monomers bearing one polymerisable C═C double bond, (B) an oil phase comprising a carrier oil (C), (D) (i) at least one water-in-oil emulsifying surfactant, and (D) (ii) at least one oil-in-water emulsifying surfactant; characterised in that the carrier oil component (C) of the oil phase comprises from 75% to 100%, by weight of the said carrier oil component (C), of farnesane (2, 6, 10-trimethyldodecane). The compositions are effective for use as thickeners for thickening aqueous solutions, including solutions which contain dissolved salts. The compositions also show excellent thickening in acidic solutions than counterpart compositions containing paraffinic oils.

Disclosed is a cosmetic or dermatological preparation which comprises one or more extracts of Saxifraga oppositifolia (purple saxifrage) and/or one or more extracts of Soldanella alpina (alpine snowbell). The use of these extracts to combat extrinsic and intrinsic skin aging is likewise described.

Disclosed is a use of Combretum micranthum extract in cosmetics. Processes such as a solvent extraction method and a chromatographic method are specifically used, it is found that a Combretum micranthum plant or its extract has the effects of moisturizing, anti-inflammatory, post-sun repair, repair of skin barrier, repair of UV-induced DNA damage, whitening, fading spots and anti-glycation and the like. The prepared Combretum micranthum extract can be added into cosmetics as an active ingredient thereof. The cosmetic or drug containing the Combretum micranthum extract has the efficacies of moisturizing, anti-inflammatory, post-sun repair, repair of skin barrier, repair of UV-induced DNA damage, whitening, anti-freckle and resisting saccharification and the like, thereby achieving the effect of skin care and beauty.

Disclosed is a method for effectively preparing mesenchymal-like stem cells, the method including: preparing human pluripotent stem cells cultured to passage 70 or lower after establishment of cell lines; inducing differentiation of the human pluripotent stem cells to produce embryoid bodies and selecting cystic embryoid bodies therefrom; loading the cystic embryoid bodies on a cell-permeable three-dimensional (3D) culture unit to isolate mesenchymal-like stem cells therefrom; isolating only monolayer-shaped cell clusters from the mesenchymal-like stem cells passing through the cell-permeable 3D culture unit; and uniformizing sizes of the monolayer-shaped cell clusters, in which the mesenchymal-like stem cells have anti-inflammatory efficacy and immunosuppression. Further, disclosed are mesenchymal-like stem cells prepared by the preparation method, a transporter or a therapeutic composition including the mesenchymal-like stem cells, and a composition for prevention or treatment of diseases that includes an active ingredient or exosomes secreted from the mesenchymal-like stem cells.

A cosmetic composition for improved penetration of skin active agents including about 0.1 to about 10 wt. % of C-glycoside; about 0.1 to about 5 wt. % of polyglyceryl-3 methylglucose distearate; about 0.1 to about 5 wt. % of sodium polyacrylate; and water, wherein the cosmetic composition is an oil-in-water emulsion, and all weight percentages are based on the total weight of the cosmetic composition. Methods for treating damaged skin with cosmetic compositions are also disclosed.

A preservative composition is described that may be used in personal care products and other products for protecting the products against bacteria and fungus during production and during use. The composition can about 3 to about 15% by weight of an organic acid; about 3 to about 15% by weight of a C.sub.8-C.sub.18 fatty alcohol; about 30 to about 60% by weight of an aromatic alcohol; and about 30 to about 60% by weight of an organic solvent.

The present invention provides compositions and methods for treating a dermatological disorder or disease.