Described herein are methods and formulations for treating, inhibiting, or ameliorating cellulite. Aspects described herein relate to formulations including a saline solution, reactive oxygen species, a rheology agent, an emollient, and a pH modifier and methods of using these formulations for treating, ameliorating, or inhibiting cellulite.

The present invention relates to polypeptides for use in treating diseases or disorders of energy homeostasis such as obesity, dyslipidemia, diabetes, insulin resistance, hyperglycemia or the metabolic syndrome. The invention also relates to polynucleotides encoding said polypeptides for use in treating diseases or disorders of energy homeostasis. Also provided by the present invention are pharmaceutical compositions comprising said polypeptides and polynucleotides for use in treating diseases or disorders of energy homeostasis. Said polypeptides, polynucleotides and pharmaceutical compositions may be administered locally, in particular locally into the visceral adipose tissue. Another aspect of the invention relates to a cosmetic product and the use of said cosmetic product for reducing body weight, in particular for reducing abdominal adipose tissue.

A graphene product obtained from Graphene Nanofibers (GNFs), having a modified crystal structure and a defined size distribution. The product is non toxic and has useful biological properties such as modification of the adipocytes phenotype. The product can be used in cosmetics.

A graphene product obtained from Graphene Nanofibers (GNFs), having a modified crystal structure and a defined size distribution. The product is non toxic and has useful biological properties such as modification of the adipocytes phenotype. The product can be used in cosmetics.

Disclosed herein are compositions and methods to increase glucose uptake and fat metabolism. The disclosed composition can comprise a PI3K agonist; a TRPM8 agonist; and a pharmaceutically, nutraceutically, or cosmetically acceptable carrier. Also disclosed is a method of treating diabetes, obesity, or metabolic syndrome in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a PI3K agonist and a TRPM8 agonist. Also disclosed is a method of treating a skin condition in a subject, comprising topically administering to a subject in need thereof an effective amount of a composition comprising a PI3K agonist and a TRPM8 agonist.

Disclosed herein are compositions and methods to increase glucose uptake and fat metabolism. The disclosed composition can comprise a PI3K agonist; a TRPM8 agonist; and a pharmaceutically, nutraceutically, or cosmetically acceptable carrier. Also disclosed is a method of treating diabetes, obesity, or metabolic syndrome in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a PI3K agonist and a TRPM8 agonist. Also disclosed is a method of treating a skin condition in a subject, comprising topically administering to a subject in need thereof an effective amount of a composition comprising a PI3K agonist and a TRPM8 agonist.

Topical compositions and methods are provided that are effective for promoting an optimal composition of dermal white adipose tissue in vivo comprising an adipogenic agent, a retarder of lipogenesis or lipolytic agent and at least one penetrant.

The invention is Total Body Moisture. The Butter is used for conditioning the scalp and hair promoting hair growth and moisturizing for natural, permed, or relaxed hair as well as healing the skin all over the entire human body. It can be used for moisturizing after bath or shower, protecting skin from some UV rays, healing minor cuts, bums, and abrasions. It also can be used to soothe itching skin from the effects of eczema or psoriasis. TBM is also used to decrease wrinkles, fine lines, and minor acne on the skin surface. The main base oil of TBM is pure African Shea Butter in any shade and variation. Carrier oils such as Coconut oil, jojoba oil, black castor oil, argan oil, hemp seed oil, wheat germ oil, almond oil, avocado oil, and grapeseed oil are used to add to the clinical benefits of the pure African shea butter base.

Provided are methods of reducing body fat in a subject, comprising locally (e.g., topically) administering one or more compounds of the Formula (I) and/or (V):

##STR00001##

or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, polymorph, tautomer, isotopically enriched derivative, or prodrug thereof, wherein X is —OR.sub.1, —SR.sub.2, or —NR.sub.3R.sub.4, and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.7′, Z, Y, n, y, and x, are as defined herein.

Provided are methods of reducing body fat in a subject, comprising locally (e.g., topically) administering one or more compounds of the Formula (I) and/or (V):

##STR00001##

or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, polymorph, tautomer, isotopically enriched derivative, or prodrug thereof, wherein X is —OR.sub.1, —SR.sub.2, or —NR.sub.3R.sub.4, and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.7′, Z, Y, n, y, and x, are as defined herein.