The present disclosure provides a method of treating cellulite in a subject in need thereof by administering a composition that comprises a protein having hyaluronidase activity to a region of skin having cellulite on the subject. Also provided are methods of reducing the appearance of cellulite in a subject in need thereof comprising administering a composition that comprises a protein having hyaluronidase activity to a region of skin having cellulite on the subject, wherein the administration results in a reduction in a grade of severity of the cellulite.

The present disclosure provides a method of treating cellulite in a subject in need thereof by administering a composition that comprises a protein having hyaluronidase activity to a region of skin having cellulite on the subject. Also provided are methods of reducing the appearance of cellulite in a subject in need thereof comprising administering a composition that comprises a protein having hyaluronidase activity to a region of skin having cellulite on the subject, wherein the administration results in a reduction in a grade of severity of the cellulite.

Provided is a skin external preparation for cellulite improvement and a cellulite improvement method that do not require any special equipment and manipulation and are capable of conveniently improving cellulite. The skin external preparation for cellulite improvement containing at least one component (A) is selected from α-glucosyl hesperidin and α-glucosyl naringin. The cellulite improvement method includes a step of externally applying the skin external preparation for cellulite improvement containing at least one component (A) selected from α-glucosyl hesperidin and α-glucosyl naringin to the skin of a target.

Provided is a skin external preparation for cellulite improvement and a cellulite improvement method that do not require any special equipment and manipulation and are capable of conveniently improving cellulite. The skin external preparation for cellulite improvement containing at least one component (A) is selected from α-glucosyl hesperidin and α-glucosyl naringin. The cellulite improvement method includes a step of externally applying the skin external preparation for cellulite improvement containing at least one component (A) selected from α-glucosyl hesperidin and α-glucosyl naringin to the skin of a target.

The present invention relates to a topical composition that can be used to treat skin laxity, cellulite and to firm, smooth and/or tone skin.

The present invention relates to a topical composition that can be used to treat skin laxity, cellulite and to firm, smooth and/or tone skin.

The invention relates to the use of various extracts of the Nephelium lappaceum plant for increasing the firmness and/or elasticity of the skin and/or mucous membranes, by increasing type I and/or type V collagen and/or LOX-L, fibulin-5, emiline-1 and/or fibrillin-1 gene and/or protein expression, and/or by decreasing CYR61 expression, in the skin and mucous membranes. Another subject of the invention relates to the use of said extracts in a cosmetic composition comprising at least one cosmetically acceptable excipient. Another subject further relates to a cosmetic care method comprising the application of the extract according to the invention or of a cosmetic composition comprising it, for increasing the firmness and/or elasticity of the skin and/or mucous membranes, by increasing type I and/or type V collagen, fibrillin-1 and/or LOX-L, fibulin-5, emiline-1 and/or fibrillin-1 gene and/or protein expression, and/or by decreasing CYR61 expression, in the skin and mucous membranes. A final subject relates to an N. lappaceum extract for use thereof, alone or in a dermatological or pharmaceutical composition, in the prevention and/or treatment of pathological conditions involving a loss of collagen protein and/or gene expression and/or a pathological loss of firmness of the skin and/or mucus membranes, such as rosacea and telangiectasia.

The invention relates to the use of various extracts of the Nephelium lappaceum plant for increasing the firmness and/or elasticity of the skin and/or mucous membranes, by increasing type I and/or type V collagen and/or LOX-L, fibulin-5, emiline-1 and/or fibrillin-1 gene and/or protein expression, and/or by decreasing CYR61 expression, in the skin and mucous membranes. Another subject of the invention relates to the use of said extracts in a cosmetic composition comprising at least one cosmetically acceptable excipient. Another subject further relates to a cosmetic care method comprising the application of the extract according to the invention or of a cosmetic composition comprising it, for increasing the firmness and/or elasticity of the skin and/or mucous membranes, by increasing type I and/or type V collagen, fibrillin-1 and/or LOX-L, fibulin-5, emiline-1 and/or fibrillin-1 gene and/or protein expression, and/or by decreasing CYR61 expression, in the skin and mucous membranes. A final subject relates to an N. lappaceum extract for use thereof, alone or in a dermatological or pharmaceutical composition, in the prevention and/or treatment of pathological conditions involving a loss of collagen protein and/or gene expression and/or a pathological loss of firmness of the skin and/or mucus membranes, such as rosacea and telangiectasia.

Provided are compositions and methods comprising a sanshool for the treatment of obesity as part of a controlled diet regime in an individual. Also provided are compositions and methods comprising a sanshool for treatment of a smoking or vaping addiction. Suitably the compositions are applied topically to the lips of the individual in response to a habitual urge to consume food, smoke or vape as required.

Disclosed is a method of treating a fine line or wrinkle in a person's skin, the method comprising topically applying to the fine line or wrinkle a composition comprising an effective amount of Commiphora mukul resin or an extract thereof that includes oleo gum resin, glycerin, water, and hyaluronic acid or a salt form thereof, wherein topical application of the composition to the fine line or wrinkle reduces the appearance of the fine line or wrinkle.