The present invention relates to a composition useful for reducing localized fat using phosphatidylcholine for a subject with localized fat deposits without pain, edema or side effects, and a method of administration thereof, and, more particularly, to a composition for localized fat reduction with reduced pain and side effects, comprising (i) phosphatidyl choline; and (ii) at least one selected from the group consisting of glycocholic acid (GCA), taurocholic acid (TCA) and salts thereof, wherein (i) and (ii) have a molar ratio of (ii)/(i) of 0.7 to 3.0, and wherein the composition is administered to the affected area of the subject at intervals of less than 4 weeks at a concentration of 25 to 50 mg/mL. The composition of the present invention provides a safe and stable formulation and is highly effective in reducing fat cells without various side effects, and may be administered to the affected area at shorter intervals to maximize the effects.

The present disclosure relates to a method for rating the severity of cellulite on a thigh or buttock in a human subject by utilizing a photonumeric scale that provides reliable results from physician-to-physician and patient-to-patient.

The present disclosure relates to a method for rating the severity of cellulite on a thigh or buttock in a human subject by utilizing a photonumeric scale that provides reliable results from physician-to-physician and patient-to-patient.

The present invention relates to a topical composition that can be applied to a subject's outer skin such as abdominal area, neck area, chest area, arms, legs, or buttocks to treat skin laxity, cellulite and to firm, smooth and/or tone skin. The topical composition contains a tripeptide, a tetrapeptide and one or more botanical extracts.

The present invention relates to a topical composition that can be applied to a subject's outer skin such as abdominal area, neck area, chest area, arms, legs, or buttocks to treat skin laxity, cellulite and to firm, smooth and/or tone skin. The topical composition contains a tripeptide, a tetrapeptide and one or more botanical extracts.

A compound of formula (I) R.sub.1-W.sub.m-X.sub.n-AA.sub.1-AA.sub.2-AA.sub.3-AA.sub.4-AA.sub.5-AA.sub.6-Y.sub.p-Z.sub.q-R.sub.2, a stereoisomer and/or cosmetically acceptable salt thereof, and a method of treatment using the compound are described. In the compound, AA.sub.1 is Asp, Gly, Asn, Gln, Ala or no amino acid; AA.sub.2 is Val, Ile, Leu or Ala; AA.sub.3 is Tyr, Phe, Trp, Lys, Arg or His; AA.sub.4 is Lys, Arg, His, Pro or Val; AA.sub.5 is Asn, Asp, Gln or no amino acid; AA.sub.6 is Thr, Ala, Ser or no amino acid. The compounds are useful for the treatment of the symptoms of skin aging and, in particular, for the treatment of skin wrinkles, the treatment of a sagging appearance of the skin, and/or the reduction of facial asymmetry.

A compound of formula (I) R.sub.1-W.sub.m-X.sub.n-AA.sub.1-AA.sub.2-AA.sub.3-AA.sub.4-AA.sub.5-AA.sub.6-Y.sub.p-Z.sub.q-R.sub.2, a stereoisomer and/or cosmetically acceptable salt thereof, and a method of treatment using the compound are described. In the compound, AA.sub.1 is Asp, Gly, Asn, Gln, Ala or no amino acid; AA.sub.2 is Val, Ile, Leu or Ala; AA.sub.3 is Tyr, Phe, Trp, Lys, Arg or His; AA.sub.4 is Lys, Arg, His, Pro or Val; AA.sub.5 is Asn, Asp, Gln or no amino acid; AA.sub.6 is Thr, Ala, Ser or no amino acid. The compounds are useful for the treatment of the symptoms of skin aging and, in particular, for the treatment of skin wrinkles, the treatment of a sagging appearance of the skin, and/or the reduction of facial asymmetry.

The present invention relates to a gas-generating micelle for reducing localized fat. In the present invention, by forming a micelle using a material having high biocompatibility and also introducing a cell-targeting ligand (peptide) onto the surface of the micelle, delivery to surrounding cells and tissues other than adipocytes can be minimized, and delivery into adipocytes can be maximized. The gas-generating micelle for reducing localized fat according to the present invention can be produced as an injectable preparation, and can be applied to local lipolysis supplements or diet beauty products that break down localized fat.

The present disclosure relates to a method for rating the severity of cellulite on a thigh or buttock in a human subject by utilizing a photonumeric scale that provides reliable results from physician-to-physician and patient-to-patient.

The present disclosure relates to a method for rating the severity of cellulite on a thigh or buttock in a human subject by utilizing a photonumeric scale that provides reliable results from physician-to-physician and patient-to-patient.