An automatic biological sample library, includes a frame, an upper computer, a control system, a liquid nitrogen tank, an insulated chamber, a transfer container, a rotary-disk rotating module, a basket lifting module, a tray shoveling module, a tube picking module and a transfer module. The rotary-disk rotating module, the basket lifting module, the tray shoveling module, the tube picking module and the transfer module are electrically connected to the control system. The automatic biological sample library includes the upper computer and the control system, and therefore can automatically control operations of the rotary-disk rotating module, the basket lifting module, the tray shoveling module, the tube picking module and the transfer module, such that automatic depositing and retrieving biological samples are achieved, human interference is reduced, the safety, reliability and convenience of depositing and retrieving are improved, automatic data management, data sharing and data analysis of biological sample information are realized.

The storage system is intended to provide users a device, that may securely hold biological samples within a canister in a space saving storage assembly. It is further an aim of the storage system to enable easy retrieval of the biological samples through a simple canister removal mechanism. Furthermore, the system includes a compact storage assembly that comprises multiple cells and canisters stacked together having efficient structural components that are suited for a typical storage tank for biological samples. Further improvements comprise a structural support for each canister, a corrugated panel structure forming a honeycomb canister organizational matrix, and a locking mechanism.

The storage system is intended to provide users a device, that may securely hold biological samples within a canister in a space saving storage assembly. It is further an aim of the storage system to enable easy retrieval of the biological samples through a simple canister removal mechanism. Furthermore, the system includes a compact storage assembly that comprises multiple cells and canisters stacked together having efficient structural components that are suited for a typical storage tank for biological samples. Further improvements comprise a structural support for each canister, a corrugated panel structure forming a honeycomb canister organizational matrix, and a locking mechanism.

A remote system for monitoring and controlling one or more devices for use in the cryogenic processing of a sample is provided. A remote server (130) is provided, capable of transmitting freezing profile data to one or more freezers (101, . . . , 10n), transmitting transportation profile data to one or more transportation devices, and transmitting thawing profile data to one or more thawing devices. The remote server is also capable of receiving detected data from the one or more freezers relating to the freezing of a sample in accordance with the freezing profile data, receiving detected data from the one or more transportation devices relating to the transportation of a sample in accordance with the transportation profile data, and receiving detected data from the one or more thawing machines relating to the thawing of a sample in accordance with the thawing profile data.

A remote system for monitoring and controlling one or more devices for use in the cryogenic processing of a sample is provided. A remote server (130) is provided, capable of transmitting freezing profile data to one or more freezers (101, . . . , 10n), transmitting transportation profile data to one or more transportation devices, and transmitting thawing profile data to one or more thawing devices. The remote server is also capable of receiving detected data from the one or more freezers relating to the freezing of a sample in accordance with the freezing profile data, receiving detected data from the one or more transportation devices relating to the transportation of a sample in accordance with the transportation profile data, and receiving detected data from the one or more thawing machines relating to the thawing of a sample in accordance with the thawing profile data.

Embodiments for a portable and compact centrifugation and thermal management system capable of separating and transporting biological samples while maintaining sample quality for periods of shipment time are described. A compact, automatic centrifuge holding exactly one sample tube is inside an insulating and thermally managed container suitable for standard shipping. A rotor to retain a sample tube is pre-balanced. An electronic controller starts, times and stops centrifugation automatically, responsive to placement of a lid. Thermal management may comprise a phase change material. Embodiments are free of user controls. Embodiments are free of the need for external power or external control.

Embodiments for a portable and compact centrifugation and thermal management system capable of separating and transporting biological samples while maintaining sample quality for periods of shipment time are described. A compact, automatic centrifuge holding exactly one sample tube is inside an insulating and thermally managed container suitable for standard shipping. A rotor to retain a sample tube is pre-balanced. An electronic controller starts, times and stops centrifugation automatically, responsive to placement of a lid. Thermal management may comprise a phase change material. Embodiments are free of user controls. Embodiments are free of the need for external power or external control.

The disclosure provides processes for temperature and pressure controlled cryopreservation of samples by using isochoric systems.

The disclosure provides processes for temperature and pressure controlled cryopreservation of samples by using isochoric systems.

Disclosed are systems and methods for the cryopreservation of biological samples. The system including a mixing device configured hold the biological sample and a cryoprotectant and mix the contents therein. The mixing device can include a basket that moves within mixing device to ensure efficient mixing of the cryoprotectant. The system further includes a cooling device to cool the sample and cryoprotectant. The method includes placing a biological sample within the basket, such that the container is subject to cooling by the cooling device. Subsequently, cryoprotectant is added while the cooling device cools the biological sample. During this process the basket is moved within the container.