The present invention is directed to a formulation and associated method for neutralizing one or more toxic chemical and/or materials including toxic industrial chemicals and toxic industrial materials, such as irritants, heavy metals, radioactive metals, acids and acid irritants, pesticides, and various agricultural chemicals, (collectively referred to as toxic chemical, materials, or simply toxins) as well as decontaminating surfaces that have come into contact with these agents. As a result, the formulation of the present invention can be used for neutralizing a broad spectrum of toxic chemicals and materials. In one embodiment, the active ingredient comprises 2,3, butanedione monoxime (also known as diacetyl monoxime (DAM)), and alkali salts thereof such as potassium 2,3-butanedione monoxime (KBDO). The formulation also typically includes a carrier in which the active ingredient is dispersed. In one embodiment, the carrier comprises polyethylene glycol (PEG); monomethoxypolyethylene glycol (mPEG); and combinations and derivatives thereof.

The present invention relates to isolated polypeptides having organophosphorous hydrolase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

A transportable and modular field-deployable hydrolysis system for neutralizing toxic chemical agents is described. The system comprises a transportable chemical process plant that is capable of operating in a remote location without significant site infrastructure. The system is also capable of operating in a maritime, shipboard environment. A flexible design allows processing of chemical agents in both batch and continuous flow modes, as well as collection and accumulation of agents from a variety of containers whose form and size may not be known until the system is on-site.

A plasticized pyrotechnic material can be easily portioned and formed or molded into a desired shape and burns at a high temperature (>2000 C.) but does not detonate. The plasticized pyrotechnic material may preferably include a combination of about 70-99% by weight of a pyrotechnic composition and about 1-30% by weight of a plasticizer composition comprising various low to mid molecular weight polyisobutylenes. The pyrotechnic material comprises inorganic oxidizers (e.g. metal oxides, oxohalide salts, nitrates, nitrites, chlorates/perchlorates) and metal or metal oxides powders mixed intimately. The plasticizer may include a small amount of a fluoropolymer, such as polytetrafluoroethylene (PTFE) and may also include up to 1-2% by weight of a processed oil, such as a mineral oil or motor oil. Some embodiments may also include a biocide precursor molecule.

Disclosed are complex coacervate core micelles comprising an enzyme capable of hydrolyzing organophosphorus compounds, such as nerve agents, and, for example, their use in remediation or decontamination of stockpiles of chemical weapons.

Disclosed herein are compositions, methods, and articles of personal protective equipment for use in detoxifying an organophosphate-based agent, wherein the compositions, methods, and articles comprise contacting the organophosphate-based agent with a cocaine esterase, wherein the contacting detoxifies the organophosphate-based agent.

A process comprising: contacting an item with a dry media to remove a first portion of a chemical warfare agent from the item; contacting the item with solvent to contaminate the solvent with a second portion of the chemical warfare agent from the item; and removing the contaminated solvent from the item. A device comprising: a first side comprising a dry media applicator to remove a first portion of a chemical warfare agent from an item; and a second side comprising an absorptive material to remove a solvent contaminated with a second portion of a chemical warfare agent from the item, wherein the first and second sides are of a unitary whole.

A decontamination composition, containing chloroperoxidase. The decontamination composition can rapidly degrade chemical warfare agents, namely mustard gas (HD), Lewisite (L) and VX, and the decontamination products of mustard gas and Lewisite are non-toxic, thereby effectively preventing the harm of the chemical warfare agents to the environment and organism, and reducing the degree of harm of the products to soil, vegetation and organism compared with conventional decontaminant agents.

A composition having a gadolinium-, samarium-, or lanthanum-substituted porous cerium oxide and copper or gold nanoparticles. The composition can be exposed to electromagnetic radiation to form reactive oxygen species in the composition to decompose organophosphonate compounds. The composition may be made by forming a mixture of a cerium salt; a gadolinium, samarium, or lanthanum salt; and an epoxide; forming gel from the mixture; and drying the gel to form an aerogel, a xerogel, or an ambigel. Copper or gold nanoparticles are added or formed at any point in the method.

The present disclosure is directed to the removal of contaminants from a contaminated surface in the field. According to one embodiment, the present disclosure is directed to a textile comprising immobilized contaminant surface removal media for contacting a contaminated surface and removal of contamination. According to a further embodiment, the present disclosure is directed to a hand mitt comprising at least one outward facing textile side comprising immobilized contaminant surface removal media. According to another embodiment, the present disclosure is directed to a process for the removal of contaminants from a surface comprising contacting a contaminated surface with a textile comprising immobilized contaminant surface removal media and thereafter disposing of the textile including removed contaminants.