A method for operating an adjustment system for an interior of a vehicle, wherein a collision-free adjustment path from an initial configuration to a final configuration is determined in a path planning routine by the control arrangement by way of intermediate configurations, wherein a collision check is performed for the intermediate configurations, in which the respective intermediate configuration is checked for the presence of a collision based on a kinematics model and a geometry model, wherein the collision-free adjustment path is generated based on the intermediate configurations and depending on the results of the collision check. A prediction of the presence of a collision is generated for the intermediate configurations by the control arrangement with the aid of a predetermined collision model based on a trained machine learning model and that the intermediate configurations are subjected to the collision check or rejected depending on the prediction of the collision check.