The present invention relates to a collagen sponge-type composition for bone regeneration characterized in that the composition is manufactured by homogenizing a hydrated collagen; and a mixed solution of the lidocaine, epinephrine and thrombin, and then lyophilizing same. The composition according to the present invention, which activates undifferentiated cells in bone marrow and also activates bone regeneration capacity in bone marrow through the activation and differentiation of osteoclasts and osteoblasts, may be a method for successful treatment of medication-related osteonecrosis of the jaw (MRONJ) through a bone marrow activation treatment method, and may develop the treatment of the fundamental causes of MRONJ through a bone marrow activation treatment method using various growth factors for bone marrow activation and bone marrow activation factors such as cytokines and completely regenerate jaw bone conditions aesthetically and functionally. Accordingly, the composition according to the present invention may be useful in the treatment of various diseases caused by bone remodeling failure.

Devices, method to produce devices and methods to perform bone augmentation using a bag having two membranes on one side and one membrane on the other side which is preferably perforated. The bag can be filled with bone augmenting material. The bag can be used in the jaws while placing the side with the one membrane towards the jaw bone and the side with the two membranes towards the gingiva.

An object for altering cell behavior includes a surface part provided with at least one topography configured to modulate at least one of morphology, proliferation, biochemical functioning, differentiation, attachment, migration, signaling, or cell death of a cell population by physical stimulation, where the at least one topography includes a surface and multiple protrusions protruding from the surface, where the protrusions define multiple valleys between adjacent protrusions such that the adjacent protrusions do not touch, where each protrusion includes at least one protrusion element, where the top surface area of the at least one protrusion element has a complex shape comprising a combination of basic shapes, interconnected by one or more overlapping portions, the basic shapes including at least one of a circle, oval, triangle, square, rectangle, trapezoid, pentagon, hexagon, heptagon or octagon.

A bone foundation guide system has a bone foundation guide including a body that is contoured to reversibly affix to a bone segment of a dental implant surgical site. The body is further contoured to guide the cutting of a portion of the bone segment from a dental implant surgical site and alternatively support a dental implant surgical guide. The body is further contoured to support a bone foundation guide prosthesis as an alternative to the dental implant surgical guide. The bone foundation guide prosthesis combines with the body to accommodate the bone segment portion as placed through the body prior to the bone segment portion being removed from the dental implant site through the use of the body.

The present invention relates to a dental implant for supporting, in particular by using a support structure, a cover element. The dental implant comprises a connection element having first and second end sections for connecting the dental implant to an implantation site of a jawbone and a first support element for supporting a cover element of at least a section of the implantation site after implanting the dental implant. The first end section is designed as, or comprises, a first connection section. The first support element comprises a second connection section. The first and second connection sections may be interconnectable. The second end section is designed as, or comprises, an implantation section for the temporary implantation of the connection element on or in the implantation site.

A system (1) for modifying a human or animal bone (2) is intended to reliably enable bone augmentation or bone reduction of the bone (2) to be treated in a particularly simple and, in particular, also particularly well-tolerated manner. For this purpose, according to the invention, a two-dimensionally extended lifting/pressure element (4) for insertion between the periosteum (6) of the bone (2) to be treated and the underlying bone (2) or the overlying connective tissue and a control element (10) associated therewith are provided, the control element (10) being designed to exert a magnetic pressure or tensile force on the lifting/pressure element (4).

Provided is a method of manufacturing a bone grafting substitute having a hole. The method of manufacturing a bone grafting substitute having a hole includes a biodegradable polymer preparation operation of preparing biodegradable polymer; a molding material preparation operation of preparing a molding material by mixing the biodegradable polymer with a bone material; a molding material injection operation of injecting the molding material into a hole forming mold for molding a bone grafting substitute having a hole; and a bone grafting substitute having a hole molding operation of drying the molding material injected into the hole forming mold at a predetermined temperature.

A dental implant system including an implant and an abutment is disclosed. The implant includes a generally cylindrical body, a central axis, a distal end for anchoring in a patient's bone and a proximal end opposing the distal end. The proximal end includes a roughened lateralized surface that surrounds an abutment-engaging region. The lateralized surface is disposed at a negative slope relative to the central axis. The abutment includes an upper portion for supporting a tooth-like prosthesis and a lower portion for engaging the abutment-engaging region of the dental implant. The diameter of the lower portion of the abutment is smaller than the diameter of the implant at its proximal end. The lower portion includes a first surface with a soft-tissue enhancing material. The first surface and the lateralized surface defining a circumferentially extending recess having a V-shaped cross-section for receiving and attachment to the soft tissue.

There is a need for a minimally invasive surgical treatment method for periodontitis for the removal of deep pockets, elimination of disease, creation of reattachment of the gingiva to the tooth surface and true regeneration of the attachment apparatus (new cementum, new periodontal ligament, and new alveolar bone) on a previously diseased root surface. The PerioLase® MVP-7™ including eGUI or another device capable of laser dosimetry, such as an original MVP-7™ type laser without the eGUI, achieves this with the LANAP protocol (laser-assisted new attachment procedure) and the LENAP protocol (laser excisional new attachment procedure).

A bone implant kit includes an implant and first and second electrical stimulation anchors. The implant defines an inner surface inner configured to face a bone to which the bone implant kit is configured to attach, and an outer surface opposite the inner surface. The implant further defines first and second bone fixation holes that each extend from the inner surface to the outer surface. The first and second bone fixation holes are spaced from each other along a longitudinal direction. The first electrical stimulation anchor can be sized and configured for insertion into the first bone fixation hole, and the second electrical stimulation anchor can be sized and configured for insertion into the second bone fixation hole. The first and second electrical stimulation anchors can be configured to respond to a magnetic field so as to generate an electric field between the first and second electrical stimulated anchors.