Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases within treated tissues, particularly within tumors and other diseased tissues. Also provided are compositions comprising the compounds and methods for using the compounds, for example in dynamically monitoring protease activity in vivo during image-guided tumor resection surgery.

On-press developable, negative-working infrared radiation-sensitive lithographic printing plate precursors have an aluminum-containing substrate having at least inner and outer aluminum oxide layers. A hydrophilic layer is present on the outer aluminum oxide layer at 0.0002-0.1 g/m.sup.2 and contains a phosphorus-containing compound represented by Formula (I) at a coverage of 50-300 mg/m.sup.2. A hydrophilic polymer can also be present at a lower coverage than that of the phosphorus-containing compound. These precursors have an on-press developable, negative-working infrared radiation-sensitive imageable layer having at least a free radically polymerizable component; an initiator composition that provides free radicals upon exposure to imaging infrared radiation; an infrared radiation absorber having an anionic chromophore; and optionally a polymeric binder that is different from all other components. Such precursors can be imaged and on-press developed to provide lithographic printing plates, and they can be readily manufactured using a particular sequence of steps including multiple anodization steps.

An embodiment of the present invention is to provide a resin composition including a near infrared absorbing coloring agent represented by Formula (1) and a resin, a resin molded article, and a method of producing a resin molded article. In Formula (1), a ring A and a ring B each independently represent an aromatic ring or a heteroaromatic ring, X.sup.A and X.sup.B each independently represent a monovalent substituent, G.sup.A and G.sup.B each independently represent a monovalent substituent, kA represents an integer of 0 to n.sub.A, kB represents an integer of 0 to n.sub.B, n.sub.A represents the largest integer of G.sup.A which may be substituted in the ring A, n.sub.B represents the largest integer of G.sup.B which may be substituted in the ring B, X.sup.A and G.sup.A, and X.sup.B and G.sup.B may be respectively bonded to one another to form a ring, and in a case where a plurality of G.sup.A's and G.sup.B's are present, the plurality of G.sup.A's and the plurality of G.sup.B's may be respectively bonded to one another to form a ring structure. ##STR00001##

The present invention provides compositions relating to nanoparticles, such as nanocapsules, that selectively target cells associated with diseases or disorders (e.g., cancer cells). The present invention further relates to methods relating to the said nanoparticles for imaging, detection, and treatment of diseases or disorders in a subject. The present invention additionally provides kits that find use in the practice of the methods of the invention.

The present disclosure relates to chemical dyes useful for staining and imaging of cells. In particular, the disclosure relates to compound of Formula I, method of preparation thereof, and it's use as a fluorescent probe for staining and/or imaging mitochondria in cells, tissues or animals, resulting in a range of applications including, but not limiting, to sensing local ordering or viscosity of mitochondria, tracking mitochondrial mobility, comparing & evaluating mitochondrial function, local ordering, microviscosity and dynamics. Said dyes have additional advantages including, but not limiting, to low toxicity, longer shelf-life, generate little or no reactive species upon long term light irradiation and do not perturb the functionality of the mitochondria in cells compared to prior art dyes.

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The present invention relates to a novel organic compound, a near-infrared fluorescent constant medium containing the same, and a method for nano-granulating the constant medium.

The present invention relates to a method for detecting renal disease and for assessing the efficacy of dialysis treatment using imaging agents having desirable in vivo properties.

The present disclosure provides polymerizable luminescent dyes useful for incorporation into polymers. The dyes and the polymers can be used in sensing and imaging applications, for example, to provide accurate and optionally long term measurements of glucose in vivo. The present disclosure also provides sensors including the polymers described herein. The sensors can be implanted into a tissue of a subject and used for long-term or short-term continuous and semi-continuous collection of data of various biochemical analytes, optionally without the use of implantable hardware of any type and/or enzymatic and electrochemical detection methods.

A near-infrared absorbent dispersion includes water, a near-infrared absorbent, and a resin dispersant, wherein a weight ratio of the near-infrared absorbent to the total weight of the near-infrared absorbent and the resin dispersant is more than 0.01 and less than 0.33.

The present invention relates to novel methine dyes, methods for the preparation thereof and use thereof for dyeing plastics, especially polyamides, so as to obtain yellow to orange colourings with improved light fastness and improved thermal stability.