A composition comprising a doubly conjugated chitosan polymer or oligomer, and a functionalized metal work piece including the doubly conjugated chitosan polymer or oligomer.

The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).

A method for manufacturing a shaped cross-linked hyaluronic acid product including the step of subjecting a non-cross-linked precipitated hyaluronic acid substrate in a desired shape to a single cross-linking reaction in a liquid medium having a pH of 11.5 or higher and including one or more polyfunctional cross-linking agent(s) and an amount of one or more organic solvent(s) giving precipitating conditions for hyaluronic acid, under suitable conditions to obtain a precipitated, shaped cross-linked hyaluronic acid product having a degree of modification of 1-40 cross-linking agent units per 1000 disaccharide units.

The present invention relates to a method for obtaining chitin and/or chitosan from insect cuticles. More particularly, the method according to the present invention comprises a first enzymatic hydrolysis of insect cuticles using at least one endopeptidase, separation from the hydrolysis medium of the hydrolyzed cuticles resulting from the first enzymatic hydrolysis, and a second enzymatic hydrolysis of the hydrolyzed cuticles using at least one endopeptidase, excluding exopeptidase.

The present invention relates to an acetylated amphiphilic carbohydrate compound of average molecular weight 1-50 kDa which is based on a glycol chitosan, wherein the levels of acetylation can be modified. The compound can be formulated with hydrophobic compounds such as drugs. The degree of acetylation of the carbohydrate compound is optimised to maximise solubilisation of the drugs. The compound is formulated with drugs and is useful in therapy.

Example compliant hydrophilic coatings including a base coat and a lubricious top coat for coating a medical device including a flexible substrate. The coatings exhibit reduced cracking and peeling in response to deformation or expansion of the flexible substrate. Example techniques for coating a medical device including a flexible substrate with compliant hydrophilic coatings.

The invention relates to a hydrogel product comprising glycosaminoglycan molecules as the swellable polymer, wherein the glycosaminoglycan molecules are covalently crosslinked via crosslinks comprising a spacer group selected from the group consisting of di-, tri-, tetra-, and oligosaccharides.

A water-soluble and/or water-swellable hybrid polymer comprising: (i) from 5 wt.-% to 95 wt.-% water-soluble and/or water-swellable polysaccharide polymer selected from the group consisting of xanthan gum, carrageenan, guar gum, chitosan, alginate and combinations thereof; (ii) from 5 wt.-% to 95 wt.-% synthetic polymer comprising up to 100 mol-% repeating units according to Formula (1a): ##STR00001##
wherein components (i) and (ii) are polymerized by radical precipitation polymerization in a polar solvent.

A method for manufacturing a compound comprising at least one imine group, the method comprising a step of reaction between a first compound comprising at least one amine group and a second compound comprising at least one carbonyl group, the reaction step being carried out in the presence of at least one supercritical fluid.

The present invention relates to a process for the preparation of crosslinked hyaluronic acid butyrate or crosslinked hyaluronic acid butyrate-formate or an acceptable salt thereof, wherein the process comprises the crosslinking reaction of hyaluronic acid butyrate or hyaluronic acid butyrate-formate or a pharmaceutically acceptable salt thereof in an organic solvent with a carboxyl activating reagent, characterized in that the hyaluronic acid butyrate or hyaluronic acid butyrate-formate or pharmaceutically acceptable salt thereof is a mixture of a high-molecular-weight polysaccharide and a low-molecular-weight polysaccharide.