Systems and methods to simulate activity that would be recorded using an interface to nerve fibers are provided. Signals, such as motor intent signals, can be converted to neural recordings, such as neural recordings by longitudinal intrafascicular electrodes (LIFEs). Spinal cord motor pools and neural interfaces can be jointly simulated. Realistic simulated neural recordings, such as from electrodes such as LIFEs, can be provided and can be used for the evaluation of decoding algorithms. Systems and methods described herein provide a framework for developing neural interface devices.

Methods for diagnosing Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) based on a diagnostic score, as well as determining MYC activity levels and selecting treatments based on a MYC activity score.

Systems and methods are described for quantifying the response of a biological system to one or more perturbations. First and second datasets corresponding to a response of a biological system to first and second treatments are received. A plurality of computational network models that represent the biological system are provided, each model including nodes representing a plurality of biological entities and edges representing relationships between the nodes in the model. A first set of scores is generated, representing the perturbation of the biological system based on the first dataset and the plurality of models, and a second set of scores representing the perturbation of the biological system based on the second dataset and the plurality of computational models. One or more biological impact factors are generated based on each of the first set and second set of scores that represent the biological impact of the perturbation on the biological system.

A system allows determining treatment parameters or sets of parameters applicable to electromagnetic radiation (EMR)-based device skin treatments that allow for upregulation of the sirtuin family of genes post treatment, while avoiding increasing collagen production. The system can be applied to other skin procedures, including chemical treatments, microdermabrasion treatments and others. The system includes classifying patient data into classifications of skin treatment and treatment parameters based on patient baseline levels. The system can determine effective treatment parameters for patients on an individual basis, to yield a healthy wound dealing response. In a specific implementation, the system determines the parameters of EMR and chemical based treatments that increase sirtuin gene expression post treatment, but do not induce collagen production.

Provided herein are methods and arrangements and related cell-free biomolecular breadboards configured to design, build, implement, debug, and/or test a genetic circuit to be operated in a target environment, by testing in a cell-free system under conditions of the target environment, molecular components of the genetic circuit and/or combinations thereof to select the molecular components and/or combinations thereof of a genetic circuit operative in the target environment.

A rapid method for characterizing and identifying microorganisms using Focal-Plane Array (FPA)-Fourier Transform Infrared (FTIR) spectroscopy is disclosed. Multi-pixels spectral images of unknown microorganisms spectra are analyzed and compared to spectra of reference microorganisms in databases. The method allows rapid and highly reliable identification of unknown microorganisms for the purpose of medical diagnosis, food and environmental control.

Systems and methods for computer-aided alignment and positioning of a prosthesis component onto a target host bone, such as in joint resurfacing arthroplasty, are discussed. A system for can include a processor unit and a user interface unit. The processor unit can receive a target bone model including a first data set representing a target bone surface, and a prosthesis model including a second data set representing a prosthesis surface. The prosthesis, when positioned against the target bone, is configured to at least partially replace the articulation surface. The processor unit can generate an articulation interface representation that indicates spatial misalignment between one or more portions of the prosthesis surface and one or more portions of the target bone surface when the prosthesis model is positioned against the target bone model.

Method, systems and apparatus to determine the suitability of parts or protocols to perform unit operations in the context of a biological process, comprising recording of a user score associated with an instance of use of a protocol or part, wherein the context of the use is recorded along with the rating, and wherein the context is defined as the value of factors that may affect the performance of the unit operation in which the part or protocol was used. The method may be implemented as a web service.

A method, computer program product, and system for generating flavor profile models are provided. An alpha flavor model is determined. An electrode signal is transmitted to a taste simulator based on the alpha flavor model. User feedback is received. A variance between the alpha flavor model and the user feedback is determined. The variance is compared to a predetermined threshold. In response to determining that the variance is greater than the predetermined threshold, a beta flavor model is generated.

The present invention relates to methods and systems for temperature correction in thermal melt analysis. More specifically, embodiments of the invention relate to the correction of the melting temperature (T.sub.m) observed for a sample nucleic acid due to the effect of the nucleic acid concentration.