Applicants have identified that three critical phenotypic/genetic measures are highly correlated with transition period health and may be used in selection and breeding protocols and/or in combination with traditional breeding and marker assisted selection methods to improve predictability of transition period health. According to the invention genetic evaluations for mastitis, ketosis, and metritis have been found to be highly predictive of overall transition health. The genetic evaluations are produced by directly measuring thousands of clinical cases of mastitis, ketosis, and metritis in ancestors of a particular animal and using this data in selection. Applicant's selection criteria and quickly impact a breeders population by reducing transition cow disease incidence in the initial population and in progeny.

A genotyping device includes a representative value calculator, a first labeler, a model creator, a second labeler. The representative value calculator calculates a representative value for each of one or more clusters with respect to each of a plurality of SNPs. The representative value being calculated based on signal intensities of specimens included in each of the clusters. The first labeler assigns genotypes to clusters of an SNP pertaining to three clusters among the SNPs on basis of the representative values of the clusters. The model creator creates a model indicative of a relationship between the genotypes of the clusters of the SNP pertaining to the three clusters among the SNPs and the representative values of the clusters. The second labeler assigns genotypes to clusters of an SNP pertaining to one or two clusters among the SNPs on basis of the representative values of the clusters and the model.

The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.

Provided herein are systems and methods for determining the epigenetic sequences and signatures of bacteria, methods of characterizing bacteria based thereon, and methods of use thereof.

A computer-implemented drug evaluation method and system provides for evaluating safety of a drug or a drug group by performing certain computations associated with gene sequence variation information of individuals within a population. The system calculates various scores for individual within a population and ultimately combines the scores in determining safety of the drug across the population. The drug evaluation method and a system can further be configured for identifying individuals having a high-risk of side effects to a drug or a drug group. The drug evaluation provides universal drug safety information based on gene sequence variation information without the need to identify specific genetic markers for each drug.

The techniques and/or systems described herein are directed to improvements in genomic prediction using homomorphic encryption. For example, a genomic model can be generated by a prediction service provider to predict a risk of a disease or a presence of genetic traits. Genomic data corresponding to a genetic profile of an individual can be batch encoded into a plurality of polynomials, homomorphically encrypted, and provided to a service provider for evaluation. The genomic model can be batch encoded as well, and the genetic prediction may be determined by evaluating a dot product of the genomic model data the genomic data. A genomic prediction result value can be provided to a computing device associated with a user for subsequent decrypting and decoding. Homomorphic encoding and encryption can be used such that the genomic data may be applied to the prediction model and a result can be obtained without revealing any information about the model, the genomic data, or any genomic prediction.

A personal skin care product ingredient analysis device based on inherent skin information includes: a user interface; a skin type database; a skin care product ingredient database; an analysis server; an analysis result database; a production control server; and a management control interface. The personal skin care product ingredient analysis device is capable of inputting personal data and skin related gene detection data, and automatically connected to a plurality of databases to perform interactive analysis, and finally personal skin care ingredient formula can be produced automatically, so that manufacturers can make suitable personal skin care products according to various inherent skin natures, so as to provide reliable and effective exclusive personal skin care product which is capable of improving skin health and delaying skin aging.

The present application is directed to methods and systems for identifying small molecule compounds in mixtures using a library comprising calculated structures and corresponding calculated mass spectral fragmentation patterns of known and/or hypothetical small molecule compounds that may be in the mixture and screening of a mass spectrum of the mixture using the library to identify matching fragmentation patterns. If a mass spectral fragmentation pattern present in the mass spectrum of the mixture matches a calculated fragmentation pattern of one of the known or hypothetical compounds this confirms the identity of a compound in the mixture as the known or hypothetical compound. The method represents a platform method that can be used for a multitude of purposes related to the screening and identification of compounds in mixtures. Therefore the methods and systems of the present application represent an approach that is uniquely capable of navigating chemical space and providing a understanding of desired families and pharmacophores.

The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof; methods of using the compounds as described herein for treating cancer, and immune disease, disorders, or conditions; methods of using the compounds as described herein for modulating cGAS and STING; and methods of designing or characterizing a cGAS modulator.

A method for generating correlations between human biological phenotype and human behavioral and/or emotional phenotype, and optionally to temporal location, comprising the steps of correlating data on biological phenotype with survey-based data on behavioral and/or emotional phenotype. The data on biological phenotype is collected from a sample from an individual, and the survey-based data can be collected from answers to behavioral and emotional questions from the individual or from observations of the individual by a third party. Correlations can further be used to predict behavior, including preferences, wellness needs and desires, and/or emotions. Feedback, advice and guidance can be provided to individuals based on such correlations. Such correlations are further useful for product and service providers and industries for purposes of standardizing or rating product quality and efficacy, and/or for promotion and selling purposes. A database comprising the data on biological phenotype and survey-based data is also provided.