A medical method of affixing an element to a surface of dentine, tooth enamel, bone tissue, or corresponding substitute material. The method includes the steps of: providing an attachment composition, the attachment composition having a mixture of: a thermoplastic component; and a hardenable (for example curable) component. The hardenable component is different from the thermoplastic component. The method further includes the steps of: positioning the attachment composition relative to the surface of dentine, tooth enamel, bone tissue, or corresponding substitute material; and activating the attachment composition to attach to the surface or to attach to the element positioned relative to the surface. The step of activating the attachment composition includes activating the attachment composition by means of mechanical vibration.

A kit for mucosally administering a metastable supersaturated solution of a pharmaceutical active agent to a human patient includes a first compartment comprising a first composition comprising a pharmaceutical active agent in solution at or below equilibrium solubility, and a second composition comprising an acidic buffer. The first and second compartments maintain separation of the first and second compositions during storage, and allow for mixing of the first and second compositions to form a supersaturated solution above equilibrium solubility of the pharmaceutical active agent for immediate mucosal administration to a human patient. In one embodiment, the second composition comprises an acidic buffer and the supersaturated solution has an acidic pH. Alternatively, the second composition comprises a basic buffer and the supersaturated solution has a basic pH.

Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation.

A mixture for an injectable scaffold may include a self-assembling core and an additive. The additive may include an angiogenic agent, a small molecule drug, and/or an anti-inflammatory agent. The scaffold can be applied to sites where bone growth is desired.

The present invention provides a method that enables production of a surface-treated colored inorganic particle with which the desired color tone can be consistently reproduced as intended with no variation occurring in the color tone of the compositions produced with the particle, within each production and over multiple production runs. The invention relates to a method for producing a surface-treated colored inorganic particle, comprising spray drying a mixture of a dispersion [I] and a solution [II], wherein the dispersion [I] is a dispersion of inorganic particles having an average particle diameter of 0.005 to 5 m dispersed in a solvent with a pigment, and the solution [II] is a solution of a surface treatment agent hydrolyzed in the presence of a hydrolysis aid.

A dental curable composition includes a polymerizable monomer, inorganic particles (A), and inorganic particles (B), wherein the inorganic particles (A) have a volume-median particle size of more than or equal to 0.1 m and less than or equal to 0.9 m and are surface-treated with a compound expressed by a general formula (1), the inorganic particles (B) have an average primary particle size of more than or equal to 5 nm and less than or equal to 50 nm, where at least one of a group expressed by a general formula (A) and a group expressed by a general formula (B) is present at surfaces of the inorganic particles (B), and the ratio of the mass of the inorganic particles (B) to the total mass of the inorganic particles (A) and the inorganic particles (B) is more than or equal to 0.02 and less than or equal to 0.05.

Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation.

To provides a polymerizable composition having high storage stability and high color stability. To provide a two-paste type dental polymerizable composition of the present invention is a two-paste type dental polymerizable composition comprising a first paste containing (A) at least one kind of polemerizable monomer, an (B) organic peroxide as a chemical polymerization initiator, and a (C) basic filler, and a second paste containing (A) at least one kind of polemerizable monomer, a (C) basic filler and an (D) aromatic amine compound as a chemical polymerization accelerator, wherein the second paste contains 30 to 80 parts by weight of the (C) basic filler based on 100 parts by weight of the total amount of the second paste.

A solid freeform fabrication material set includes a material A for solid freeform fabrication and a material B for solid freedom fabrication. The material A includes a polymerization initiator A and at least one of an organic particle and an inorganic particle. The material B includes a polymerizable compound B.

The present disclosure provides a composite material, a method of making and using the composite material and dental products made by hardening the composite material. The composite material includes a polymerizable component, ceramic fibers and nanoclusters. Each of the ceramic fibers of the composite material has a length and where the length of fifty percent of the ceramic fibers, based on a total number of the ceramic fibers, is at least 50 micrometers and the length of ninety percent of the ceramic fibers, based on the total number of the ceramic fibers, is no greater than 500 micrometers. The composite material can also include discrete non-fumed metal oxide nanoparticles. The composite material can be hardened to become any one of a dental restorative, a dental adhesive, a dental mill blank, a dental cement, a dental prostheses, an orthodontic device, an orthodontic adhesive, a dental casting material or a dental coating.